Chiefs vs. Cardinals Week 1 Betting: Will Mahomes outlast Murray in desert duel?

In what could be one of the most exciting games on the Week 1 schedule, Kyler Murray and the Arizona Cardinals will welcome Patrick Mahomes and the Kansas City Chiefs to State Farm Stadium on Sunday afternoon.

Their opener against Arizona is part of an early gauntlet for Kansas City, who will follow their trip to the desert with this stretch: Chargers (home), Colts (away), Bucs (away), Raiders (home), Bills (home), 49ers (away), bye week, Titans (home).

So, a win right out of the gate will be key for KC, especially with many people wondering how well their vaunted offense will fare with Tyreek Hill now with the Miami Dolphins.

But the Cards started fast in each of the past two seasons and will be aiming to do the same this season, though this year–and perhaps the future of coach Kliff Kingsbury–will be defined on how they finish.

Kansas City Chiefs vs. Arizona Cardinals Matchup Information and Betting Odds

Matchup Information

• Matchup: Kansas City Chiefs (0-0) vs. Arizona Cardinals (0-0)
• Venue & Location: State Farm Stadium (Glendale, Arizona)
• Date: Sunday, September 11, 2022
• Game Time: 4:25 p.m. Eastern Time (1:25 p.m. local time)
• Chiefs vs. Cardinals TV Info: CBS

Chiefs vs. Cardinals Betting Odds

Game odds are via BetOnline. Odds from other recommended legal sports betting sites may also appear in this article.

Spread

• Kansas City Chiefs -5.5 (-115)
• Arizona Cardinals +5.5 (-105)

Over/Under

• Over 53.5 (-105)
• Under 53.5 (-115)

Moneyline

• Kansas City Chiefs -255
• Arizona Cardinals +210

Kansas City Chiefs vs. Arizona Cardinals Prediction and Best Bets

Chiefs vs. Cardinals Score Prediction: Kansas City 38, Arizona 30

Chiefs vs. Cardinals Best Bets: Kansas City/Arizona over 53.5 (Best Value: -105 at BetOnline)

Other Chiefs vs. Cardinals Content on Betting News

• Chiefs vs. Cardinals Consensus Picks & Score Projections

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