Boston Red Sox vs. Houston Astros Picks and Predictions (8/12): Can Boston Pull Off Road Win?

Two teams near the top of the American League go head to head tonight in Houston as the Astros host the Boston Red Sox. Both teams are in tight divisional races and both need to continue stacking wins as the playoffs inch closer. Let's get into our favorite picks for tonight's matchup.

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Boston Red Sox vs. Houston Astros: MLB Picks & Predictions

The visitors have lost three straight and now sit 4.5 games behind the Toronto Blue Jays in the AL East. Boston has lost four of their last five as well, but prior to this slump, they won seven straight. However they are just 12-10 since the All Star Break, and they also lost to the Astros last night, 7-6.

Houston leads the AL West by just one game over the Seattle Mariners. A little further back are the Texas Rangers who sit 6.5 games out of first place, so they could also make a run. The Astros have won two in a row and three of their last four, and are 11-12 since the break.

It's worth noting that Houston is also 36-24 at Daikin Park this season. Can they add another win tonight against the Red Sox?

Matchup Information – Red Sox vs. Astros – August 12

• Venue & Location: Daikin Park (Houston, TX)
• Date: Tuesday, August 12, 2025
• First Pitch: 8:10 p.m. Eastern

Pitching Matchup

• Boston Red Sox: Dustin May (6-8, 4.93 ERA, 1.37 WHIP)
• Houston Astros: Spencer Arrighetti (1-2, 7.43 ERA, 1.58 WHIP)

Red Sox vs. Astros Betting Odds

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Run Line

• Red Sox +1.5 (-205)
• Astros -1.5 (+177)

Moneyline

• Red Sox -104
• Astros -106

Total

• Over 8.5 (-105)
• Under 8.5 (-115)

Dustin May and Spencer Arrighetti start for their squads tonight. May has made just one start for the Red Sox since coming over, and it was rough. He gave up three runs on six hits in just 3.2 innings against the Royals at Fenway Park, taking the loss.

On the other side, Arrighetti has made three MLB starts this year, and is coming back from an injury. In his first start back, he gave up five runs on 11 hits in just 3.2 innings, including a home run. I faded this man plenty last season with his 4.53 ERA and 1.41 WHIP, and I'm not sure tonight will be any different.

Boston Red Sox vs. Houston Astros MLB Best Bets

Red Sox vs. Astros MLB Prediction: Red Sox Win, Over 8.5

Best Bet: Red Sox ML (-104) BetOnline

Give me Boston on the road.

The Red Sox hit .253 as a team but have hit .265 and .256 over the past two months. They were one of the hottest teams in baseball a week ago, and I trust them to get back on track tonight.

Boston swept the Astros two weekends ago, and although we've got new starting pitchers, the bats remain the same. The Red Sox have outscored the Astros 21-12 in four games this season, leading the series 3-1. Tonight I have them getting another win, their first in Houston this season.

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