Toronto Blue Jays vs. New York Yankees MLB Picks and Predictions: May 20, 2026
Written by: Nate Hornung
Published: Wed May 20, 2026, 2:25 pm ET
Read Time: 5 minutes
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So far this week, we've had success targeting these MLB divisional matchups. We cashed the over in Cleveland vs. Detroit on Monday, and yesterday we took a stab at the Brewers over the Cubs and walked away a winner. After placing wagers in the AL and NL Central, tonight we move to the AL East, where the New York Yankees host the Toronto Blue Jays for the third of four games in this series. Let's get right into our favorite MLB picks for tonight.
Check out the best odds on the market at our top online sportsbooks.
Toronto Blue Jays vs. New York Yankees MLB Betting Insights
Trey Yesavage and the Blue Jays are just 8-16 on the road this season
The Yankees lead this series two games to none, and now have a chance to secure a series win with a victory tonight. Throughout the season, these teams will meet plenty of times, but the Blue Jays need to be focused on tonight's contest. They have now dropped two straight, and have fallen to 11.5 games back in the division, although they are in third place.
The Yankees sit in second in the AL East, just three games behind the Tampa Bay Rays. They've now won two straight, but are 10-8 during the month of May. Will they be able to rally around their right handed stud tonight?
Cam Schlittler and Trey Yesavage get the starts for their team, so let's look at their stats and find some wagers in this game.
Matchup Information – Blue Jays vs. Yankees – May 20
- Venue & Location: Yankee Stadium (Bronx, NY)
- Date: Wednesday, May 20, 2026
- First Pitch: 7:05 p.m. Eastern
- Broadcast: MLB Network
Blue Jays vs. Yankees Pitching Matchup
- Toronto Blue Jays: RHP Trey Yesavage (1-1, 1.40 ERA, 1.29 WHIP)
- New York Yankees: RHP Cam Schlittler (6-1, 1.35 ERA, 0.78 WHIP)
Blue Jays vs. Yankees Betting Odds
Odds are courtesy of our friends at Lucky Rebel Sportsbook, as of May 20, 2026, at 2:00 p.m. eastern. Sign up today and get a $1,250 deposit bonus as well as 50 slot spins immediately in your account and start betting at the sportsbook with the most competitive odds in the industry, and a wide variety of unique markets not offered anywhere else.
Run Line
- Blue Jays +1.5 (-147)
- Yankees -1.5 (+127)
Moneyline
- Blue Jays +145
- Yankees -175
Total
- Over 7.5 (-115)
- Under 7.5 (-105)
Toronto Blue Jays vs. New York Yankees MLB Picks
Cam Schlittler has a sub 1.00 ERA over his last six starts. He already leads the league in that category
Blue Jays vs. Yankees Prediction: New York Wins and Covers, Over 7.5
Best Bet: Yankees -1.5 (+127) Lucky Rebel Sportsbook
Cam Schlittler has been shoving, and like Jacob Misiorowski of the Brewers, I am not willing to fade him. He leads the MLB with a 1.35 ERA and is second with a 0.78 WHIP. Although his splits actually decline at home, he's been throwing fire recently. Over his last six starts, Schlittler has allowed just three earned runs. For all you math folks, in Schlittler's last 32.1 innings, he has a 0.84 ERA, a 0.81 WHIP, and is averaging almost one strikeout per inning.
The Blue Jays are an abysmal 8-16 on the road this year. Over the last two weeks, the Blue Jays rank No. 24 in the MLB in batting average and second worst in the league in wOBA. Compare that to the Yankees, who are in the top half of the MLB in wOBA during the same two week period. Quite simply, the Yankees have been better.
They lead the American League in run differential, while ranking second in runs allowed as well. The Blue Jays are one of the few remaining teams who have yet to score 200 runs this year. The offense has not been producing like it needs to be. I think that continues tonight as Schlittler shoves, resulting in the Yankees covering this run line.
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Nate has been a recreational sports bettor for about 5 years. In that time, he has grown to love the pursuit of winners and sticking it to The Man. Nate loves data and uses his understanding of numbers to help him be a more profitable sports gambler, however he will be the first to tell you this game is about more than just stats.
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