Rays vs Red Sox Prediction, Odds & Picks (Sept. 27): Tampa Bay Keeps Dominating AL East Rivalry

Devon Platana

Written by: Devon Platana

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rays vs red sox prediction, odds & picks


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Wednesday, Sept. 27’s MLB schedule features the second game in as many days between the Tampa Bay Rays and Boston Red Sox. After Tampa Bay won last night’s back-and-forth affair, all eyes are on the Rays to see if they can complete the two-game sweep.

The Rays emerged on the right side of last night’s 9-7 shootout with the Red Sox. Seven different Tampa Bay players recorded at least one RBI in the victory, led by center fielder Manuel Margot who went 4-for-4 in the batter’s box with two RBIs.

So, who’ll be the victor of the final Rays vs. Red Sox showdown of the 2023 MLB season?

This betting preview attempts to answer that question and more. So, buckle up, and let’s take a look at the latest MLB odds, as well as my betting predictions for tonight’s AL East collision.

Rays vs Red Sox Tonight (Sept. 27)

TB vs. BOS Game Information

  • Matchup: Tampa Bay Rays (96-62, 43-34 Away) vs. Boston Red Sox (76-81, 39-41 Home)
  • Venue & Location: Fenway Park (Boston, MA)
  • Date: Wednesday, Sept. 27, 2023
  • Game Time: 6:10 p.m. Eastern Time
  • Where to Watch Rays vs. Red Sox Tonight: MLB.TV, NESN, Bally Sports Sun, ESPN+

Rays vs Red Sox Odds

Game odds as of Wednesday, Sept. 27 at 11:39 a.m. ET, courtesy of Bovada. Odds from other reputable sportsbooks may also be mentioned in this article.


  • Tampa Bay Rays -1.5 (+140)
  • Boston Red Sox +1.5 (-165)


  • Over 7.5 Runs (-105)
  • Under 7.5 Runs (-115)


  • Tampa Bay Rays -122
  • Boston Red Sox +102

Rays vs Red Sox Probable Pitchers (Sept. 27)

  • Rays: Tyler Glasnow (20 starts — 9-7, 3.68 ERA)
  • Red Sox: Brayan Bello (27 starts — 12-10, 4.11 ERA)

Rays vs Red Sox Betting Trends

  • Tampa Bay is 6-3 straight up in its last nine road games.
  • Boston is 3-12 straight up in its last 15 home games.
  • The total has hit the Over in each of Tampa Bay’s last six games.
  • The total has hit the Under in six of Boston’s last eight AL East matchups.
  • The total has hit the Over in three of the last four Tampa Bay-Boston matchups.

Rays vs Red Sox Game Preview

Thursday’s victory was business as usual for Tampa Bay fans.

The Rays have had the Red Sox’s number throughout the 2023 campaign, now winning 10 of the 12 matchups between the AL East rivals. Tampa Bay is also 4-1 at Fenway Park this season, having won the last four meetings in Boston 23-12 on aggregate.

Playing at home is supposed to provide a boost, but that hasn’t been the case for the Red Sox for quite some time. They’ve emerged as losers in 12 of their last 15 home games, scoring three or fewer runs seven times during that span.

Following yesterday’s defeat, Boston is now 12-13 against AL East clubs at home while Tampa Bay is 12-10 in divisional away games. Furthermore, the Rays head into tonight’s contest riding a five-game winning streak on the road.

Rays vs Red Sox prediction, odds & picks
RHP Tyler Glasnow looks to lead the Rays to victory tonight.

The Rays are turning to right-handed starter Tyler Glasnow on the mound tonight. The 30-year-old veteran hasn’t been his usual self lately going 1-2 with a putrid 8.22 ERA in his last three starts, allowing four earned runs in each outing.

At the same time, Glasnow hasn’t lost to the Red Sox since 2018 — a nine-game span. Since that defeat, he’s amassed a 3-0 record against Boston, pitching to a 3.06 ERA while striking out 72 batters over just 47 innings.

The good news for the Rays is that Red Sox RHP Brayan Bello is also looking vulnerable at the moment. He was absolutely destroyed when he faced the Texas Rangers last Wednesday, giving up two HRs and eight earned runs on as many hits over just three innings in a 15-5 loss for Boston.

Bello has also experienced mixed results against the Rays this season. While he scored the win when he last faced Tampa Bay on Sept. 4, he was credited with the loss when the Red Sox fell 4-1 to the Rays on June 5.

Rays vs Red Sox Prediction (Sept. 27)

Tampa Bay has had Boston’s number all season long and there isn’t a reason to believe tonight’s result will be any different. The Rays know how to find success at Fenway Park and Glasnow’s success against the Red Sox only improves the visitor’s odds of victory.

Prediction: TB 5, BOS 2

Bet: TB -1.5 (+140 on Bovada)

Rays vs Red Sox Player Prop

If you’re looking for a Rays vs. Red Sox player prop, let’s hammer the Over on Tyler Glasnow’s 7.5-strikeout total.

Glasnow is a strikeout machine, averaging 12.0 Ks per nine innings this season. He’s finished with the Over on this prop eight times in his last 15 starts, which includes a 14-strikeout performance when he faced the Red Sox earlier this month.

Averaging 8.4 strikeouts in his last eight clashes with Boston, I’d be surprised if Glasnow doesn’t rack up the Ks again.

Bet: Tyler Glasnow o7.5 Strikeouts (-115 on SportsBetting)

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Devon Platana
Devon Platana

Devon is a Master of Journalism graduate who joined the sports betting world in 2020. His favorite leagues to cover are the NHL, NBA and NFL, and has a soft spot for fantasy football specifically. Outside of sports, he enjoys the finer things in life like pasta, live music and getting even more tattoos.

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