Guardians vs. Red Sox (July 27) Odds and Best Bets: Odds Tight as Teams Try to Take Lead in the Series

Nicholas Plowfield

The Red Sox and Guardians meet for the sixth time this season in Boston on wednesday night. Boston leads the season series 4-1, but they have had a rough go of things lately, losing 10 of their last 12.

The Cleveland Guardians are 6-4 in their last 10 games and they won the last time out against Boston last night. They dropped Boston to last place in the AL East, even though their record sits at 49-49.

According to FanDuel, the Red Sox have a slight edge in the odds, and they will send Nathan Eovaldi to the hill. The Guardians will counter with Cal Quantrill who will go for a win in his 4th straight start.

Cleveland Guardians vs. Boston Red Sox Matchup Information and Betting Odds

Matchup Information

  • Matchup: Cleveland Guardians (49-47, 24-28 away, 2nd in the AL Central) vs. Boston Red Sox (49-49, 24-24 home, 5th in the AL East)
  • Venue & Location: Fenway Park (Boston, Massachusetts)
  • Date: Wednesday, July 27, 2022
  • Game Time: 7:10 p.m. Eastern Time
  • TV Broadcast/Streaming Info: Bally Sports Great Lakes (Guardians), NESN (Red Sox), MLB Extra Innings/MLB Network (subscription packages)

Guardians vs. Red Sox Pitching Matchup

  • Cleveland Guardians: Cal Quantrill (2022: 18 starts, 7-5, 3.75 ERA)
  • Boston Red Sox: Nathan Eovaldi (2022: 14 starts, 4-3, 4.30 ERA)

Guardians vs. Red Sox Odds

Game odds are via FanDuel. This article may also feature odds from other legal online sportsbooks that we have reviewed and recommend.


  • Cleveland Guardians +110
  • Boston Red Sox -130


  • Over 8.5 (-112)
  • Under 8.5 (-108)

Run Line

  • Cleveland Guardians +1.5 (-176)
  • Boston Red Sox -1.5 (+146)

Pitching Matchup

Cal Quantrill will take the mound for Cleveland for the 19th time this season. He has a 7-5 record, and has won his last 3 starts in a row. In those last 3 starts, he has dropped his ERA by 0.24 and has only allowed 6 earned runs.

Nathan Eovaldi will make his 15th start for Boston aiming for his first win in 3 starts. He will also look to rebound from his last time out. He got tagged with 9 earned runs in just 2.2 innings.

On Wednesday night, pitching will be a key component to victory. Both pitchers are giving up runs, but they are doing so at different rates. Overall, their season ERA is similar, and both have been tagged in starts.

Both pitchers have a fairly high WHIP over 1.00, and their strikeout totals are low. Both pitchers will have to pitch to contact to be successful. However, both pitchers have combined to give up 30 home runs this season, so keeping the ball on the ground will be a must.

Cleveland Guardians vs. Boston Red Sox Prediction and Best Bets

Guardians vs. Red Sox Prediction: Guardians to win

Guardians vs. Red Sox Best Bets: Guardians ML (+110 at FanDuel)

Cal Quantrill is on a hot streak, and his last three starts have been impressive. Add that to the fact that the Red Sox have lost 10 of 12, and this is a recipe for success for Cleveland.

Their value is high, due to the fact that they are the underdog. However, Nathan Eovaldi has struggled lately, giving up 12 runs in his last 2 starts. I would put my faith in the team having more current success.

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Nicholas Plowfield
Nicholas Plowfield