CBS Sports

Dimers

Dratings

DunkelIndex

GameSim

OddsShark

Pickwatch

VSiN

Moneyline

Total

Point Spread

Away/Home

Wins

Ov / Un

Cardinals

Ali Sánchez

Andrew Knizner

Yadier Molina

Iván Herrera

Austin Romine

Nolan Arenado

Edmundo Sosa

Paul DeJong

Paul Goldschmidt

Tommy Edman

Brendan Donovan

Juan Yepez

Albert Pujols

Kramer Robertson

Nolan Gorman

Cory Spangenberg

Alec Burleson

Dylan Carlson

Lars Nootbaar

Tyler O'Neill

Harrison Bader

Corey Dickerson

Conner Capel

Ben DeLuzio

Steven Matz

Angel Rondón

Alex Reyes

Miles Mikolas

T.J. McFarland

Nick Wittgren

Johan Quezada

Brandon Waddell

Giovanny Gallegos

Dakota Hudson

T.J. Zeuch

Jack Flaherty

Kodi Whitley

Jake Walsh

Adam Wainwright

Johan Oviedo

Ryan Helsley

Jake Woodford

Freddy Pacheco

Drew VerHagen

Jordan Hicks

Génesis Cabrera

Junior Fernández

Packy Naughton

Aaron Brooks

Andre Pallante

Matthew Liberatore

Zack Thompson

James Naile

Jose Quintana

Chris Stratton

Jordan Montgomery

JoJo Romero

Cubs

Miguel Amaya

Yan Gomes

P.J. Higgins

Willson Contreras

Nick Madrigal

Frank Schwindel

Andrelton Simmons

Patrick Wisdom

Sergio Alcántara

Alfonso Rivas

David Bote

Nico Hoerner

Jonathan Villar

Ildemaro Vargas

Zach McKinstry

Esteban Quiroz

Alexander Canario

Harold Ramirez

Christopher Morel

Ian Happ

Michael Hermosillo

Greg Deichmann

Clint Frazier

Jason Heyward

Rafael Ortega

Nelson Velázquez

Seiya Suzuki

Jackson Frazier

Narciso Crook

Franmil Reyes

Jared Young

Adbert Alzolay

Tommy Nance

Keegan Thompson

Michael Rucker

Ethan Roberts

Scott Effross

Brailyn Marquez

Codi Heuer

Wade Miley

Rowan Wick

Anderson Espinoza

Alexander Vizcaino

Brad Wieck

Cory Abbott

Marcus Stroman

Kyle Hendricks

Manuel Rodriguez

Alec Mills

David Robertson

Justin Steele

Chris Martin

Drew Smyly

Daniel Norris

Mychal Givens

Jesse Chavez

Mark Leiter Jr.

Sean Newcomb

Locke St. John

Robert Gsellman

Adrian Sampson

Conner Menez

Brandon Hughes

Alfredo Romero

Matt Swarmer

Caleb Kilian

Eric Stout

Steven Brault

Erich Uelmen

Kervin Castro

Matt Dermody

Javier Assad

Nicholas Padilla

Luke Farrell

Brendon Little

Jeremiah Estrada

Hayden Wesneski

Away/Home Defense

Away/Home Offense

Defense

Offense

St. Louis Cardinals vs Chicago Cubs Picks

Wrigley Field

<p>After splitting the first four games of their series, the St. Louis Cardinals and Chicago Cubs are set for a rubber game this afternoon at Wrigley Field.</p>
<p>Last night, the Cubs were sharp at the plate and on the mound in a 7-1 win. Little went right for the Cards, including Nolan Arenado getting ejected at the end of the third inning.</p>
<figure class="embed strchf-type-embed regular strchf-size-regular strchf-align-center">
<div class="embed-container">
<blockquote class="twitter-tweet">
<p lang="en" dir="ltr">Arenado is ejected after a check-swing third strike call that ended the inning.</p>
<p>TV: Bally Sports Midwest<br />Stream: <a href="https://t.co/M4t6YHHY8M">https://t.co/M4t6YHHY8M</a><a href="https://twitter.com/hashtag/STLCards?src=hash&amp;ref_src=twsrc%5Etfw">#STLCards</a> <a href="https://t.co/VX6oLCIUbp">pic.twitter.com/VX6oLCIUbp</a></p>
<p>&mdash; Bally Sports Midwest (@BallySportsMW) <a href="https://twitter.com/BallySportsMW/status/1562605050702483456?ref_src=twsrc%5Etfw">August 25, 2022</a></p></blockquote>
<p><script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>
</div>
</figure>
<p>With the Milwaukee Brewers off today, St. Louis has a chance to extend their lead in the NL Central to six games ahead of a visit from the high-flying Atlanta Braves.</p>
<h2 id="f22r1">St. Louis Cardinals vs. Chicago Cubs Matchup Information and Betting Odds</h2>
<h3 id="a61e5">Matchup Information</h3>
<ul>
<li>Matchup: St. Louis Cardinals (71-53, 31-32 away, 1st in the NL Central) vs. Chicago Cubs (54-70, 28-37 home, 3rd in the NL Central)</li>
<li>Venue &amp; Location: Wrigley Field (Chicago, Illinois)</li>
<li>Date: Thursday, August 25, 2022</li>
<li>Game Time: 2:20 p.m. Eastern Time (1:20 p.m. local time)</li>
<li>Cardinals vs. Cubs TV Info: MLB Network</li>
</ul>
<h3 id="ft6ql">Cardinals vs. Cubs Pitching Matchup</h3>
<ul>
<li>St. Louis Cardinals: Dakota Hudson (2022: 22 starts, 6-6, 4.33 ERA)</li>
<li>Chicago Cubs: Marcus Stroman (2022: 17 starts, 3-5, 3.83 ERA)</li>
</ul>
<h3 id="apj5t">Cardinals vs. Cubs Odds</h3>
<p><strong><em>Game odds are via BetOnline. This article may also include odds from other top online sports betting sites.</em></strong></p>
<h4 id="6s5kv">Moneyline</h4>
<ul>
<li>St. Louis Cardinals -116</li>
<li>Chicago Cubs -102</li>
</ul>
<h4 id="bfncv">Over/Under</h4>
<ul>
<li>Over 9.5 (-110)</li>
<li>Under 9.5 (-110)</li>
</ul>
<h4 id="5f9uq">Run Line</h4>
<ul>
<li>St. Louis Cardinals -1.5 (+132)</li>
<li>Chicago Cubs +1.5 (-160)</li>
</ul>
<h2 id="ef0n2">Offense to Stand Out in Series Finale at Wrigley</h2>
<p>After two tight, low-scoring contests to start the series, the last two games have featured more scoring but have both been more one-sided.</p>
<p>This afternoon’s series finale may well end up being one-sided, but both offenses should have some success. </p>
<p>Hudson has had an issue with pitching deep into games all season, exiting short of five completed innings ten times in his 22 starts and lasting only five four times. </p>
<p>On the road, Hudson has gone five innings only five times in 12 starts, including just once in his last five road starts. </p>
<p>Short starts aren’t always poor starts, but he has allowed four or more five times on the road, including in his most recent start against the Arizona Diamondbacks last Saturday (4.1 IP, 5 H, 4 R, 4 BB, 3 K). </p>
<p>It didn’t hurt the team though, as the bats racked up 16 runs and 18 hits in a nine-run win, but he’ll certainly be expected to fare better in today’s matchup, which will be his first start against the Cubs this season.</p>
<h3 id="4d1u3">Season Splits for Dakota Hudson</h3>
<ul>
<li>Home (10 starts): 4-2, 3.25 ERA, 55.1 IP, 50 H, 20 R (20 ER), 3 HR, 18 BB, 30 K, .251 OBA, 1.22 WHIP</li>
<li>Away (12 starts): 2-4, 5.34 ERA, 59 IP, 59 H, 36 R (35 ER), 5 HR, 35 BB, 36 K, .274 OBA, 1.59 WHIP</li>
</ul>
<p>While Hudson has been poorer on the road, Stroman’s home splits are poorer. </p>
<h3 id="cjaoo">Season Splits for Marcus Stroman</h3>
<ul>
<li>Home (7 starts): 0-3, 6.62 ERA, 35.1 IP, 33 H, 28 R (26 ER), 8 HR, 14 BB, 40 K, .243 OBA, 1.33 WHIP</li>
<li>Away (10 starts): 3-2, 2.08 ERA, 56.1 IP, 47 H, 18 R (13 ER), 4 HR, 11 BB, 43 K, .224 OBA, 1.03 WHIP</li>
</ul>
<p>His worst start of the season came against the Cardinals at home on June 3. In a 14-5 loss, he allowed nine runs and 10 hits (including three homers). </p>
<p>After that start, he went on the injured list for a month with shoulder inflammation. He has yet to lose in eight starts since his returning, but his numbers have dropped off a bit this month after he allowed only two runs in four starts last month.</p>
<p>But he had his best home start of the season&#8211;and his longest start of the season&#8211;last time out against the Brewers last Saturday. In 7.2 innings, he allowed two runs, two hits, and four walks and struck out five.</p>
<p>He could be in some trouble today, based on what the Cardinals have done recently. </p>
<p>In a run that has seen them win 20 of their last 26 games, St. Louis has scored five or more runs 18 times. Additionally, they are 8-1 in their last nine games following a loss and have scored five or more runs in all but one win, a 3-1 win over Milwaukee almost two weeks ago.</p>
<h2 id="cn2qf">St. Louis Cardinals vs. Chicago Cubs Prediction and Picks</h2>
<p><strong>Cardinals vs. Cubs Prediction:</strong> Cardinals to win</p>
<p><strong>Cardinals vs. Cubs Picks:</strong> St. Louis team total over 4.5 runs (Best Value: -122 at <a href="https://affiliates.bettingnews.com/register/betonline/" target="_blank" rel="noopener noreferrer">BetOnline</a>) &amp; Cardinals/Cubs over 9.5 (Best Value: -110 at <a href="https://affiliates.bettingnews.com/register/bovada/" target="_blank" rel="noopener noreferrer">Bovada Sportsbook</a>, <a href="https://affiliates.bettingnews.com/register/bmgm/" target="_blank" rel="noopener noreferrer">BetMGM</a> &amp; BetOnline)</p>
<p>There have been ten or more total runs six times in Hudson’s last eight road starts, while there have been 11 combined runs in each of Stroman’s home starts this month.</p>
<p>Plenty of runs should be on the board today at Wrigley, but most of them should be by St. Louis. Look for them to continue their great run with rebounding from losses. </p>
<p>That expected outcome means that the run line is also worth consideration. In their 20-6 run, the Cards have won by 2+ runs 15 times, and in their last eight wins following a loss, they have won by 2+ runs each time.</p>
<h2 id="a4nqm">More Cardinals vs. Cubs Content</h2>
<ul>
<li><a href="/mlb/matchup/2022-08-25-st_louis_cardinals-chicago_cubs-n-1/">Cardinals vs. Cubs Odds, Stats &amp; Trends (8/25)</a></li>
</ul>
<p><script>if(window.strchfSettings === undefined) window.strchfSettings = {};window.strchfSettings.stats = {url: "https://betting-news.storychief.io/en/cardinals-cubs-prediction-picks-august-25-2022?id=1147028166&type=2",title: "Cardinals vs. Cubs (August 25): Cards, Cubbies set for high-scoring finale?",id: "4af471aa-0a59-40f0-a023-eeb51e59464b"};(function(d, s, id) {var js, sjs = d.getElementsByTagName(s)[0];if (d.getElementById(id)) {window.strchf.update(); return;}js = d.createElement(s); js.id = id;js.src = "https://d37oebn0w9ir6a.cloudfront.net/scripts/v0/strchf.js";js.async = true;sjs.parentNode.insertBefore(js, sjs);}(document, 'script', 'storychief-jssdk'))</script></p>

Cardinals vs. Cubs (August 25): Cards, Cubbies set for high-scoring finale? cover

Cardinals vs. Cubs (August 25): Cards, Cubbies set for high-scoring finale?

MLB Plays & Props for Sunday, May 3

Cleveland Guardians vs. Athletics Picks and Predictions: May 3, 2026

Get dialed into Saturday's MLB slate, with our picks, analysis and more. Our expert dishes out a pair of MLB best bets for today's slate.

MLB Best Bets for Saturday, May 2: Yearning for More Yankees

Bobby Witt and the Royals have struggled offensively on the road this year - Royals Mariners Picks

Kansas City Royals vs. Seattle Mariners Picks and Predictions: May 1, 2026

Check out where there is value to be had on the diamond on Friday night, as our MLB analyst dished out his MLB best bets, picks and analysis.

MLB Best Bets for Friday, May 1: Riding the Run Lines