Dimers

Dratings

DunkelIndex

FiveThirtyEight

GameSim

OddsShark

SportGrid

Sports Betting Dime

VSiN

Wunderdog

pickwise

Moneyline

Total

Point Spread

Away/Home

Wins

Ov / Un

Astros

Martín Maldonado

Jason Castro

Korey Lee

Will Smith

Christian Vázquez

Yainer Diaz

Niko Goodrum

Taylor Jones

Alex Bregman

Yuli Gurriel

Jeremy Peña

Joe Perez

Aledmys Díaz

J.J. Matijevic

Mauricio Dubón

Trey Mancini

David Hensley

Jose Siri

Kyle Tucker

Jake Meyers

Jose Altuve

Michael Brantley

Chas McCormick

Yordan Alvarez

Roilan Machandy

Blake Taylor

Framber Valdez

Bryan Abreu

Héctor Neris

Rafael Montero

Peter Solomon

Seth Martinez

Pedro Báez

Jake Odorizzi

Shawn Dubin

Ryne Stanek

Lance McCullers Jr.

José Urquidy

Cristian Javier

Forrest Whitley

Ryan Pressly

Tyler Ivey

Brandon Bielak

Luis García

Enoli Paredes

Phil Maton

Jonathan Bermudez

Justin Verlander

Josh James

Ronel Blanco

Parker Mushinski

Hunter Brown

Orioles

Robinson Chirinos

Anthony Bemboom

Adley Rutschman

Jorge Mateo

Ryan Mountcastle

Tyler Nevin

Rougned Odor

Ramón Urías

Kelvin Gutierrez

Kevin Smith

Terrin Vavra

Rylan Bannon

Chris Owings

Richie Martin

Jonathan Araúz

Gunnar Henderson

Jesús Aguilar

Yusniel Diaz

Jahmai Jones

Anthony Santander

Ryan McKenna

DJ Stewart

Austin Hays

Cedric Mullins

Kyle Stowers

Brett Phillips

Dean Kremer

Keegan Akin

Zac Lowther

Tyler Wells

Mike Baumann

Alexander Wells

Kyle Bradish

Joey Krehbiel

Tanner Scott

Isaac Mattson

Cionel Pérez

Cole Sulser

Bruce Zimmermann

Logan Gillaspie

Paul Fry

Felix Bautista

Dillon Tate

Bryan Baker

John Means

Jorge López

DL Hall

Jordan Lyles

Spenser Watkins

Travis Lakins Sr.

Marcos Diplán

Chris Ellis

Logan Allen

Denyi Reyes

Nick Vespi

Beau Sulser

Cody Sedlock

Austin Voth

Rico Garcia

Kirk McCarty

Louis Head

Yennier Cano

Jake Reed

Away/Home Defense

Away/Home Offense

Defense

Offense

Houston Astros vs Baltimore Orioles Picks

Oriole Park at Camden Yards

<p>Thursdays are rarely one of the more notable days of the week on the MLB schedule, but with teams jockeying for division titles and playoff spots, there are a number of important games on today’s schedule, including in Baltimore, where the Orioles open a four-game series with the Houston Astros.</p>
<p>Houston has the AL West locked up, but in addition to seeking their 100th win of the season, tonight could be the night that Justin Verlander all but wraps up his third AL Cy Young Award.</p>
<p>The Astros are also in position to do the Seattle Mariners some favors in this series, as the Mariners are currently four games ahead of the Orioles for the final AL wild-card spot. </p>
<p>Regardless of what Seattle does today against the Oakland A’s or this weekend against the Royals, the O’s cannot afford to lose this series. </p>
<p>A loss tonight wouldn’t necessarily be devastating, given how shaky Seattle has been recently. But opening the series with a win over the likely AL Cy Young winner could set the stage for a winning weekend in Baltimore. </p>
<h2 id="2qvic">Houston Astros vs. Baltimore Orioles Matchup Information and Betting Odds</h2>
<h3 id="c9rcj">Matchup Information</h3>
<ul>
<li>Matchup: Houston Astros (99-51, 49-28 away, 1st in the AL West) vs. Baltimore Orioles (77-71, 42-32 home, 4th in the AL East)</li>
<li>Venue &amp; Location: Oriole Park at Camden Yards (Baltimore, Maryland)</li>
<li>Date: Thursday, September 22, 2022</li>
<li>Game Time: 7:05 p.m. Eastern Time</li>
</ul>
<h3 id="c8ahu">Astros vs. Orioles Pitching Matchup</h3>
<ul>
<li>Houston: RHP Justin Verlander (2022: 25 starts, 17-3, 1.78 ERA)</li>
<li>Baltimore: RHP Kyle Bradish (2022: 20 starts, 3-7, 5.05 ERA)</li>
</ul>
<h3 id="ejjsd">Astros vs. Orioles Odds</h3>
<p><strong><em>Game odds are via <a href="https://affiliates.bettingnews.com/register/betonline/" target="_blank" rel="noopener noreferrer">BetOnline</a>. This article may also include odds from our other <a href="/best-online-sportsbooks/" target="_blank" rel="noopener noreferrer">recommended legal sports betting sites</a>.</em></strong></p>
<h4 id="bd0i0">Moneyline</h4>
<ul>
<li>Houston Astros -210</li>
<li>Baltimore Orioles +176</li>
</ul>
<h4 id="c92ld">Over/Under</h4>
<ul>
<li>Over 7 (-104)</li>
<li>Under 7 (-118)</li>
</ul>
<h4 id="bdm68">Run Line</h4>
<ul>
<li>Houston Astros -1.5 (-118)</li>
<li>Baltimore Orioles +1.5 (-102)</li>
</ul>
<h2 id="f7p3e">Houston Astros vs. Baltimore Orioles Prediction and Best Bets</h2>
<p><strong>Astros vs. Orioles Prediction:</strong> Houston to win</p>
<p><strong>Astros vs. Orioles Best Bets:</strong> Houston -1.5 (Best Value: -106 at <a href="https://affiliates.bettingnews.com/register/betus/" target="_blank" rel="noopener noreferrer">BetUS</a>)</p>
<p>When Verlander last went up against the Orioles, he exited after three innings with a calf injury and had to spend a couple of weeks on the IL.</p>
<p>Prior to that early exit on August 28, Verlander had pitched three scoreless innings and struck out six. In his return last Friday, he picked up where he left off, throwing five no-hit innings and striking out nine against the A’s. </p>
<p>Over his last three starts, Verlander has allowed no runs, three hits, and two walks and struck out 25 in only 14 innings. </p>
<p>The odds are strong that tonight will be another good night on the mound, and it could all but ensure that he will beat out Dylan Cease and Shane McClanahan for this year’s AL Cy Young. </p>
<p>Since allowing seven runs in 3.2 innings in a loss to the White Sox on June 18, Verlander is 9-0 with a 1.21 ERA in 12 starts (10 earned runs allowed in 74.2 IP).</p>
<p>Verlander has been consistently good overall this season, allowing more than two runs only seven times in 25 starts, including three times in 12 road starts. </p>
<h3 id="cm3qb">Home and Away Splits for Justin Verlander in 2022</h3>
<ul>
<li>Home (13 starts): 9-1, 1.78 ERA, .208 OBA, 0.91 WHIP</li>
<li>Away (12 starts): 8-2, 1.78 ERA, .161 OBA, 0.77 WHIP</li>
</ul>
<p>All that said, when Kyle Bradish last faced the Astros, he pitched eight shutout innings in a win on August 26. So, he knows how to handle Houston.</p>
<p>But can he do it at home, where he has yet to win in 11 starts? It must be noted that though Bradish hasn’t been credited with a home win, the Orioles have won five times in his 11 home starts. Also, Baltimore is 7-3 in his last 10 starts after going 5-5 in his first 10 starts.</p>
<p>But since losing the first two games of last month’s series against the Orioles, the Astros are 18-4, and 14 of those wins have come by 2+ runs. And with Verlander on the mound, I like the Astros to add to both of those numbers tonight.</p>
<h2 id="132tk">More Astros vs. Orioles Content on Betting News</h2>
<ul>
<li>Astros vs. Orioles Consensus Picks, Score Projections &amp; Betting Stats (9/22)</li>
</ul>
<h2 id="c9q8f">More MLB Content on Betting News</h2>
<ul>
<li>Mariners vs. Athletics Prediction &amp; Best Bets (9/22)</li>
</ul>
<p><script>if(window.strchfSettings === undefined) window.strchfSettings = {};window.strchfSettings.stats = {url: "https://betting-news.storychief.io/en/astros-orioles-prediction-picks-september-22-2022?id=542377145&type=2",title: "Astros vs. Orioles (September 22): Will Verlander lock up AL Cy Young tonight in Baltimore?",id: "4af471aa-0a59-40f0-a023-eeb51e59464b"};(function(d, s, id) {var js, sjs = d.getElementsByTagName(s)[0];if (d.getElementById(id)) {window.strchf.update(); return;}js = d.createElement(s); js.id = id;js.src = "https://d37oebn0w9ir6a.cloudfront.net/scripts/v0/strchf.js";js.async = true;sjs.parentNode.insertBefore(js, sjs);}(document, 'script', 'storychief-jssdk'))</script></p>

Astros vs. Orioles (September 22): Will Verlander lock up AL Cy Young tonight in Baltimore? cover

Astros vs. Orioles (September 22): Will Verlander lock up AL Cy Young tonight in Baltimore?

Cleveland Guardians vs. Athletics Picks and Predictions: May 3, 2026

Get dialed into Saturday's MLB slate, with our picks, analysis and more. Our expert dishes out a pair of MLB best bets for today's slate.

MLB Best Bets for Saturday, May 2: Yearning for More Yankees

Bobby Witt and the Royals have struggled offensively on the road this year - Royals Mariners Picks

Kansas City Royals vs. Seattle Mariners Picks and Predictions: May 1, 2026

Check out where there is value to be had on the diamond on Friday night, as our MLB analyst dished out his MLB best bets, picks and analysis.

MLB Best Bets for Friday, May 1: Riding the Run Lines

Kevin Gausman takes the mound tonight at Target Field against the Twins - Blue Jays Twins Picks

Blue Jays vs Twins Odds, Preview & Prediction for Thursday, April 30