Astros vs Mariners Prediction, Odds & Picks (Sept. 26): Houston Locks Down Wild Card Race

Devon Platana

Written by: Devon Platana

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Astros vs Mariners Prediction, Odds & Picks (Sept. 26): Houston Locks Down Wild Card Race cover


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The Houston Astros and Seattle Mariners clash for the second time in as many days when they collide on Tuesday night. After Houston opened the three-game Astros vs Mariners series with a victory, all eyes are on Seattle to see if it can bounce back.

The Astros marched into T-Mobile Park last night and secured a 5-1 win over the Mariners. Yordan Alvarez and Kyle Tucker each recorded home runs for Houston while SP Justin Verlander allowed one run with eight strikeouts over eight innings of work for the victory.

With that being said, here’s a look at the latest Astros vs. Mariners betting odds, as well as a prediction and the best bets for tonight’s matchup.

Astros vs Mariners Tonight (Sept. 26)

HOU vs. SEA Game Information

  • Matchup: Houston Astros (86-71, 47-29 Away) vs. Seattle Mariners (84-72, 41-34 Home)
  • Venue & Location: T-Mobile Park (Seattle, WA)
  • Date: Tuesday, Sept. 26, 2023
  • Game Time: 10:05 p.m. Eastern Time
  • Where to Watch Astros vs. Mariners Tonight: MLB.TV, TBS, ROOT SPORTS, AT&T SportsNet Southwest

Astros vs Mariners Odds

Game odds as of Tuesday, Sept. 26 at 11:13 a.m. ET, courtesy of SportsBetting. Odds from other reputable sportsbooks may also be mentioned in this article.


  • Houston Astros +1.5 (-181)
  • Seattle Mariners -1.5 (+161)


  • Over 8 Runs (-105)
  • Under 8 Runs (-115)


  • Houston Astros +113
  • Seattle Mariners -123

Astros vs Mariners Probable Pitchers (Sept. 26)

  • Astros: Cristian Javier (29 starts — 9-4, 4.64 ERA)
  • Mariners: George Kirby (29 starts — 11-10, 3.58 ERA)

Astros vs Mariners Betting Trends

  • Houston is 10-2 straight up in its last 12 road games.
  • Seattle is 2-5 straight up in its last seven home games.
  • The total has hit the Over in five of Houston’s last seven games on a Tuesday.
  • The total has hit the Under in four of Seattle’s last six games as the favorite.
  • The total has hit the Under in six of the last nine Houston-Seattle matchups.

Astros vs Mariners Game Preview

Tonight’s Astros vs. Mariners showdown is filled with playoff implications.

Both clubs are in the thick of the American League playoff race as the Astros occupy the No. 3 wild-card spot while the Mariners sit 1.5 games behind them. Houston is also 2.5 games back of the Texas Rangers for the AL West lead while Seattle is four games away from taking the division’s top spot.

Unfortunately, the Mariners’ recent play has left their fans concerned regarding their team’s postseason outlook. After all, Seattle is in the midst of a four-game losing streak at T-Mobile Park, getting outscored 23-7 on aggregate along the way.

Furthermore, the Mariners don’t tend to perform well when their AL West rival comes to town, highlighted by the Astros picking up victories in seven of their last nine trips to Seattle.

Astros vs Mariners prediction, odds and picks
Can the Astros pick up another win at T-Mobile Park?

The Mariners will also have a tough time winning if George Kirby can’t get his act together. While the 25-year-old righty has been solid for the majority of the season, he’s just 1-2 with a 5.56 ERA in his last six starts.

On the flip side, time will tell which version of Cristian Javier will be on the mound for the Astros.

The veteran righty hasn’t been his most consistent self lately, going 1-2 with a 5.61 ERA in his seven previous starts. At the same time, he’s coming off a strong showing that saw him allow only one run with 11 strikeouts over five innings last Wednesday.

Furthermore, Javier is 3-1 with a 2.45 ERA in nine career meetings (five starts) against the Mariners, which includes just four earned runs allowed over 7 2/3 innings pitched at T-Mobile Park.

Astros vs Mariners Prediction (Sept. 26)

Even though the Mariners are 8-3 against the visitors this season, I’m taking the Astros to win. Seattle’s home play has been awful lately and the club seems to crumble more often than not when Houston comes to town.

Assuming that Javier builds off his latest showing, the Astros are in a good spot to cement their wild-card status tonight.

Prediction: HOU 5, SEA 3

Bet: HOU ML (+113 on SportsBetting)

Astros vs Mariners Player Prop

If you’re looking for an Astros vs. Mariners player prop, let’s go with Yordan Alvarez recording 2+ total basses.

Alvarez has been one of the Astros’ most consistent hitters, batting .339 while amassing seven HRs, 21 hits, and 48 total bases over his last 18 games. He’s averaging 2.7 TBs during that span, hitting the Over on this prop 12 times — including in each of the last four games.

With 22 TBs in his last 10 trips to T-Mobile Park, I’m confident Alvarez will have another productive showing tonight.

Bet: Yordan Alvarez 2+ Total Bases (+117 on SportsBetting)

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Devon Platana
Devon Platana

Devon is a Master of Journalism graduate who joined the sports betting world in 2020. His favorite leagues to cover are the NHL, NBA and NFL, and has a soft spot for fantasy football specifically. Outside of sports, he enjoys the finer things in life like pasta, live music and getting even more tattoos.

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