Bengals vs. Saints Week 6 Betting: Will Burrow-led Bengals return in QB’s return to Louisiana?

Devon Platana

Week 6 of the 2022 NFL season is here, leaving fans and bettors with no shortage of exciting games to anticipate. One matchup to keep an eye on is a tilt between the Cincinnati Bengals and New Orleans Saints.

Things looked promising after the Bengals won back-to-back games, but they were brought back down to earth in a 19-17 loss to the Baltimore Ravens last week.

Meanwhile, the Saints snapped a three-game losing skid with a 39-32 win over the Seattle Seahawks. New Orleans got contributions from several key players in the victory, including Taysom Hill, who account for four of his team’s touchdowns (three rushing, one passing).

Betting News has gathered the latest Bengals vs Saints odds from FanDuel Sportsbook to help shed some light on the situation, along with a prediction and best bets for the NFL Week 6 game.

Cincinnati Bengals vs New Orleans Saints Week 6 Matchup Information and Betting Odds

Matchup Information

  • Matchup: Cincinnati Bengals (2-3, 1-2 Away) vs. New Orleans Saints (2-3, 1-2 Home)
  • Venue & Location: Caesars Superdome (New Orleans, Louisiana)
  • Date: Sunday, Oct. 16, 2022
  • Game Time: 1 p.m. Eastern Time
  • Bengals vs Saints Info: CBS

Bengals vs Saints Early Odds

Game odds are via FanDuel as of Wednesday, Oct. 12 at 7:36 a.m. ET. Odds from other top online sportsbooks may also be mentioned in this article.


  • Cincinnati Bengals -1.5 (-110)
  • New Orleans Saints +1.5 (-110)


  • Over 43.5 Points (-110)
  • Under 43.5 Points (-110)


  • Cincinnati Bengals -126
  • New Orleans Saints +108

Bengals vs. Saints Gameday Odds

Game odds are via FanDuel.


  • Cincinnati Bengals -3 (-118)
  • New Orleans Saints +3 (-104)


  • Over 43.5 (-106)
  • Under 43.5 (-114)


  • Cincinnati Bengals -164
  • New Orleans Saints +138

Cincinnati Bengals vs New Orleans Saints Betting Trends

  • Cincinnati is 11-2 against the spread (ATS) in its last 13 games.
  • New Orleans is 4-11 ATS in its last 15 games against the AFC North.
  • Cincinnati is 4-2 straight up in its last six games against New Orleans.
  • New Orleans is 2-6 straight up in its last eight home games.
  • The total has hit the under in each of Cincinnati’s last 10 games.
  • The total has hit the under in eight of New Orleans’ last 12 games.

Cincinnati Bengals vs New Orleans Saints Prediction and Picks

Bengals vs Saints Prediction: Bengals 27, Saints 17

Bengals vs Saints Picks: Bengals -1.5 (Best Value: -110 at FanDuel) & Over 43.5 Points (Best Value: -110 at FanDuel)

Both the Bengals and Saints look to climb up to .500 with a victory on Sunday. Neither team has met expectations this season, making it interesting to see who emerges as the victor this weekend.

Having said that, I do expect to see the Bengals win here. Despite already losing three times, each of those losses came by either two or three points. In other words, Cincinnati could easily be 5-0 instead of 2-3 had a few more plays gone in its favor.

Meanwhile, the Saints have succeeded more against bad teams. Their two victories came against the Seahawks and Atlanta Falcons — hardly the best that the NFL has to offer — and were only won by one possession.

On top of that, New Orleans boasts one of the worst defenses in the NFL. Not only do the Saints surrender the ninth-most rushing yards per game, but they also average 25.6 points against — tied for the league’s sixth-worst mark.

This might be a revenge game for Saints QB Andy Dalton, but the Bengals defense has been solid this year. The unit is only allowing 17.8 points per game (No. 8) and has recorded five interceptions this season.

Can Saints QB Andy Dalton have a big game against his former team?

Besides, while Dalton is 2-0 against his former team, he’s hardly put up eye-popping stats against Cincinnati. In those two starts, the veteran signal-caller completed 25-of-34 passes for 241 passing yards and three touchdowns.

At the same time, Bengals QB Joe Burrow and wideout Ja’Marr Chase will be making their return to Louisiana after spending their collegiate days at LSU. Though New Orleans’ pass defense has been solid this year, the 245 passing yards it surrendered in Week 5 was the 10th-highest total of all 32 teams.

At the end of the day, if Geno Smith could torch the Saints last week, Burrow and co. can do the same on Sunday. Cincinnati’s offense has shown glimpses of promise this season, but a matchup against a weak New Orleans defense should wake them up.

The Bengals should have no issue covering the 1.5-point spread, even on the road. They’re 11-2 against the spread in their last 13 games and 5-1 ATS in their last six outings against the Saints, so there’s no reason to question if they can cover or not.

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Devon Platana
Devon Platana