Best NCAA Basketball Picks and Predictions: Huge Saturday Slate

Nate Hornung

Written by: Nate Hornung

Published: Sat Dec 20, 2025, 9:10 am ET

Read Time: 5 minutes

Dillon Mitchell is a glue guy for the Johnnies. He does whatever the team needs every single game - St. John's UConn Picks

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Saturday is here and we have a massive NCAA Basketball slate upon us. Check out our expert's favorite picks on today's slate and see if you will tail or fade their selections.

We've been slipping during the recent weeks, but it's time to turn this ship back around.

  • NCAA Basketball YTD
  • 65-61 (51.6%)
  • -0.58u
  • Average Odds: -105

More Saturday NCAA Basketball Coverage

Go check out what else I've got on my daily card, and view the latest odds at the best online sportsbooks.

Best NCAA Basketball Picks and Predictions December 20

#22 St. John's Red Storm vs. Kentucky Wildcats Picks NCAA Basketball Picks

Ricky P leads his team against the Kentucky Wildcats this afternoon - NCAA Basketball Picks

Ricky P leads his team against the Kentucky Wildcats this afternoon

Best Bet: St. John's/Kentucky Over 156.5 (-110) Lucky Rebel Sportsbook

I snagged a bad number here, but I still think it soars over. Both of these teams are stupid fast, they attack the glass and draw contact, resulting in plenty of free throws from either side. That's my entire cap.

This game is going to be a track meet, but if you want a pick on the side, check out why Colby Marchio is backing the Johnnies here.

Longwood Lancers vs. North Carolina Central Eagles NCAA Basketball Picks

Best Bet: NC Central +5 (-110) Lucky Rebel Sportsbook

Back the home underdogs with me in this game. The NC Central Eagles are 4-9 on the year and 4-1 at home. However, they do not have a win over a Division 1 team yet this season. They have only obliterated lower level colleges this season. It's about time they pick up the win, and at home is the perfect time to do so. It's not like they've been losing to nobodies, as this team has played the 11th toughest schedule in college hoops so far this season. This isn't a team that wows you with statistics, but for as bad as they have been, they are still top 100 at getting to the line and are top 60 in FT%, shooting over 76% as a team.

As for the Lancers, they have payed the 328th easiest schedule this year but aren't good offensively. They have a flukey win over James Madison, but having lost to Wake Forest by three on Wednesday, I'm not sure they have enough left in the tank to compete on the road against a very motivated Eagles team.

Grand Canyon Lopes vs. Wyoming Cowboys NCAA Basketball Picks

Leland Walker leads the Cowboys with 14.0 points per game and 1.4 assists - NCAA Basketball Picks

Leland Walker leads the Cowboys with 14.0 points per game and 1.4 assists

Best Bet: Wyoming -2.5 (-110) Lucky Rebel Sportsbook

We are backing the Cowboys to win, in a game that I don't think they should be favored in. Put on those tin foil hats, and let's back the home favorite. Wyoming plays fast and have competed in all of their losses so far this season, dropping games to Sam Houston by eight and to Texas Tech by just four, both on the road. They have been perfect at home, and I see it continuing.

Wyoming shoots the ball very well, they crash the glass on both ends of the floor, and they defend the perimeter better than anyone in the country. Grand Canyon's offense has certainly taken a step back this season, but they are good at cleaning up the defensive boards. Ultimately, they like to play slower, and I see the hosts speeding things up and forcing them to play more defense than they are used to. Neither team has a top 100 win this season, but I lean with the hosts to get the job done tonight.

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Nate Hornung
Nate Hornung

Nate has been a recreational sports bettor for about 5 years. In that time, he has grown to love the pursuit of winners and sticking it to The Man. Nate loves data and uses his understanding of numbers to help him be a more profitable sports gambler, however he will be the first to tell you this game is about more than just stats.

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