USA vs Wales Prediction & Picks: Will the Stars and Stripes have a winning start in Qatar?

Eddie Griffin

Written by: Eddie Griffin

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USA vs Wales Prediction & Picks: Will the Stars and Stripes have a winning start in Qatar? cover


After agonizingly missing out on the 2018 World Cup, the USA will make its return to the big stage tomorrow when they take on Wales in their first match of the 2022 World Cup. Stay tuned!

Missing out on a ticket to an eighth straight World Cup meant that qualification for Qatar was an absolute must, and while they didn’t make it easy on themselves at all, the USMNT did what needed to be done to avoid back-to-back disappointments.

The reward for successful qualification is a spot in Group B with England, Wales, and Iran. England enter the tournament as one of the favorites to go all the way, but it is the USA who has the edge over Wales as the oddsmakers’ choice to join England in the round of 16.

To position themselves to back that up, the Stars and Stripes must get a positive result against Gareth Bale and Wales, who are in the World Cup for the second time ever, with their previous appearance coming in 1958.

Will we see a winning start for the USMNT? Read on for our USA vs Wales prediction and picks.

United States vs Wales Matchup Information and Betting Odds

Matchup Information

  • Matchup: United States vs Wales (2022 FIFA World Cup Group B)
  • Venue & Location: Ahmad bin Ali Stadium (Al Rayyan, Qatar)
  • Date: Monday, November 21, 2022
  • Game Time: 2:00 pm ET (10 pm local time)
  • How to Watch USA vs Wales: FOX

USA vs Wales Odds

Odds are via BetOnline as of Sunday, November 20, 2022, at 6:45 pm ET. This article may also include odds from our other recommended legal sports betting sites.


  • USA to win +135
  • Draw +200
  • Wales to win +230

Total Goals Over/Under

  • Over 2.5 goals (+152)
  • Under 2.5 goals (-186)

Both Teams to Score

  • Yes +106
  • No -134

USA vs Wales Prediction and Picks

USA vs Wales Prediction: USA to win

USA vs Wales Picks: USA ML (Best Value: +140 at BetUS) & Both Teams to Score – NO (Best Value: -134 at BetOnline)

While their recent form is pretty uninspiring, I do expect the USMNT to turn up for their World Cup return.

Wales will not be easy to break down, but I see this one ending 1-0 or 2-0 in favor of the Stars and Stripes.

Other 2022 World Cup Content at Betting News

Eddie Griffin
Eddie Griffin

Eddie Griffin has been writing about and betting on sports for over a decade and has been with Betting News since 2021. For more of his thoughts on sports and sports betting, you can follow him on X, formerly known as Twitter.

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