NFL Week 16 Staff Picks: Best Bets & Props from our NFL Staff
Written by: Daniel Collins
Last Update: Sun Dec 21, 2025, 12:35 pm ET
Read Time: 9 minutes
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Happy Holidays from all of us here at Betting News! The season is in full swing & the NFL is here to give us some gifts this weekend!
Week 16 is ready to roll and there are some fantastic matchups on this Saturday & Sunday slate and lots of money to be made.
Below, our Team here at Betting News is going to give their BEST BETS for the Week 16 NFL Slate. Whether it is a Spread, Moneyline, Total or Player Prop, this is your go to article every week for our team's favorite bets!
Here is the Squad's Record after Week 15:
(112-68 of All Picks -120 or better odds)
Daniel Collins (SPJ): 12-3
Chef T: 8-7
Nate Hornung (Shaggy): 7-8
Colby Marchio: 8-7
John Hyslop (Slop): 8-7
Varun Sharma (Sauce): 11-4
Brad Blakemore (Betzky): 10-5
Danny Burke: 10-5
Kate Constable: 7-8
Adam Kaufman: 11-4
Tristan Vieira (Trizzy): 13-2
Sukh Brar: 7-8
Now let's dive in to the Betting News Experts' Best Bets for NFL Week 16!
All Odds available at Lucky Rebel, the industry leader in the Sports betting Market.
Daniel Collins' (SPJ) (12-3) Week 16 Best Bet
Be Like Mike on Sunday
Mike Evans o55.5 Receiving yards (-115)
What is this line? Did the books forget that Mike Evans is back? I guess so…let's take advantage.
In his return to the lineup last week agains the Falcons, Evans racked up 132 yards, in 6 catches on a whopping 12 targets. Yea…seems Mike is indeed back.
The Cherry on top? Evans faces off with the Panthers, a team he has dominated.
Evans has 60+ receiving yards in 11 of his last 12 games against Carolina. Ladder this bad boy up to 100+ if you're feeling frisky, but the 56 should be easy work for the Bucs main man in a massive game for the NFC South standings.
Chef T's (8-7) NFL Week 16 Best Bet
Darren Waller o27.5 Receiving Yards (-115)
This Bengals defense has been giving up free money underneath… and Waller is a chain-mover, not a "needs one bomb" type.
If they're gonna bring pressure and play soft in the middle, he's the exact safety valve this offense leans on… quick outs, seams, sit routes, easy pitch-and-catch.
27.5 is disrespectful for a dude that's a vital piece when they actually need a drive… give me Waller to clear this on volume alone.
Nate Hornung's (7-8) NFL Week 16 Best Bet
Vikings/Giants Under 43 (-110)
Two bad offenses go head to head. The Vikings are bottom seven in the NFL in points per game, and bottom four in yards per play. Plus they are second worst at converting on third downs. The Giants aren't much better, ranking bottom 10 in scoring and bottom five in red zone scoring percentage.
Defensively, the Giants are actually No. 18 in third down conversions, and I have faith in them stopping a bad Minnesota offense. The Vikings have a rock solid defense, ranking top 10 in yards allowed per game, third down conversions and are second in the NFL in red zone scoring allowed.
Smells like an under to me.
Colby Marchio's (8-7) NFL Week 16 Best Bet
Justin Herbert should torch the Cowboys' secondary
Justin Herbert Over 241.5 Passing Yards (-115)
We just watched "No. 9," a.k.a. JJ McCarthy, sling it all over Jerry's World last week for 250 yards. This season, everyone is throwing over this number in Dallas. The Cowboys are allowing nearly 280 passing yards per game at home.
Herbert has only cleared this line five times this season and hasn't gone over since November 2nd. He is due.
John Hyslop's (8-7) NFL Week 16 Best Bet
Jahmyr Gibbs 100+ Rushing Yards (+280)
We needed a banger, and damn it, this is a banger. Maybe even better than a banger, but I don't even know if there is a word for that yet. We're talking cutting-edge shit right here. People don't know this, but the Pittsburgh Steelers' run defense is in shambles. They can't stop anyone. We're talking 5+ yards a carry over the last three games. That's bad.
Couple that with the fact that Gibbs has seen three tough matchups in a row, and we're presented with a sweet, sweet buy-low opportunity. This could easily be the greatest bet we ever make. Feels right.
Varun Sharma's (11-4) NFL Week 16 Best Bet
Chris Olave and the Saints should handle the Jets
Chris Olave 61.5 Receiving Yards (-110)
In the Saints' last four games, all four with Shough under center; Olave's seeing a 33.8% first read target share, directly leading to a 24.3% target share and 22 total receptions in that time frame.
What stood out to me was the fact that four of Shough's six starts have come on the road. When you look at his two home starts you can see how much better he's been in front of the home crowd and in the dome. Shough's completing 72% of his passes when in the Super Dome and averaging 257.5 pass yards per game. He's thrown the ball a total of 75 times in two games and 28.2% of his pass attempts went to Olave.
In the two home games, Olave's garnered 22 targets, reeling in 15 for 155 yards and 1 touchdown. Olave's first read target share jumps to 40% in these two home games and it's very obvious to see; when Shough's playing well it because Olave's been a big part of the offense.
Brad Blakemore's (10-5) NFL Week 16 Best Bet
Tyron Tracey o51.5 rush yards (-115)
The G-Men are facing one of the toughest defenses in the league, still without many of their top receiving threats. And while Dart and Winston have found success in the air, the ground game has been key for NYG. Tracey has hit this line in 4 of the L5 games.
While Dart had 63 rushing yards last week, many were not from designed plays, as the Giants look to not expose him too much coming back from a concussion. The Vikings are more susceptible to rushing attacks, allowing the 8th most yards to RBs.
Danny Burke's (10-5) NFL Week 16 Best Bet
D'Andre Swift Over 12.5 Carries (-105)
The Bears feature the second-best rushing offense in the league, and that'll be on full display Saturday night. Swift is averaging 14.7 carries, per game, has rushed the ball 13+ times in 10/13 games this season and will be in a great position to do so again. He'll be on the field more than usual, too, considering the Bears' lack of receiving weapons due to injury, and since Swift is their top receiving back – he should be seeing more action than usual.
Kate Constable's (7-8) Week 16 NFL Best Bet
Achane has a DELICIOUS matchup against the Bengals
Devon Achane Over 80.5 Rushing Yards
This is a great spot for Devon Achane against a terrible Bengals defense. Cincinnati has been getting gashed at home, allowing the most rushing yards in the league, and they just gave up another 100-yard day to Derrick Henry last week. Over their last three games, the Bengals are giving up nearly 5.5 yards per carry, and that number ballooned to over 8.0 yards per attempt a week ago, which is alarming.
Achane has been on an absolute heater, piling up 580 rushing yards on 84 carries over his last five games, averaging 116 yards per game, well above both his season average and this prop line. With Quinn Ewers starting in place of Tua, Miami may look to run the ball even more than they already have been, further benefitting Achane.
Adam Kaufman's (11-4) NFL Week 16 Best Bet
Vikings -2.5 (-110)
I think J.J. McCarthy is terrible, so you KNOW I mean it. This is like when I bet on the Jaguars. Take sentimentality out of it.
This line is trappy. I don't get it. Minnesota isn't good, but it's far superior to New York.
McCarthy's rallied the Vikes to two straight wins and should shellack a defense that's near-last in the NFL. The run-D stinks, so have a day, Aaron Jones and Jordan Mason.
The Giants have dropped their last eight, and Jaxson Dart is awful under pressure.
Both teams play to the over this year, so maybe the move is O43.5, but I'm gonna lean on McCarthy to smack the G-Men around in the Meadowlands.
Tristan Vieira's (13-2) NFL Week 16 Best Bet
Dak & the Cowboys might be out of it, but could handle business Sunday
Cowboys -2 (-105)
The Cowboys have been eliminated from the playoffs and losers of 2 straight games. They are taking on a red hot Chargers team coming in very high off stealing a divisional game over the Chiefs, knocking them out of the playoffs. Yet some how, the Chargers find themselves as 2 point underdogs traveling to Dallas?
This line stinks and makes 0 sense, the Cowboys are banged up and have played so poorly they have no business being favorites here. The books know something and I'm riding with them, give me the Cowboys to upset and get back in the win column at home on Sunday.
Sukh Brar's (7-8) NFL Week 16 Best Bet
Buccaneers -3.0 (-105)
Panthers have surprised a lot of people. A deeper look into their record is even more surprising.
They have 6 games scoring fewer than 13 points. The other teams who have done that are the Raider, Browns, and Titans. Their combined records are just 7-35.
The Panthers 28th ranked offence should be a get right spot for a team where everything is going wrong.
Coaches are fighting for their jobs, players for their futures, let's just hope they fight as one.
Enjoy NFL Week 16!
You can also check out more free picks & analysis from every NFL Week 15 Matchup!
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Daniel Collins is a sports fanatic and data-driven bettor. He has expertise in the NFL, NBA, and NHL. He’s a big fan of the Titans #titanup, Predators #predators and Arsenal #coyg. If he isn’t watching, betting on or writing about sports, he loves the outdoors, traveling, strong coffee and delicious food. You can follow him on X @SweatpantJesus. Peace and Love
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