NFL Preseason Week 3 Predictions, Odds, Picks for All 16 Games

Devon Platana

Believe it or not, we’ve already arrived at Week 3 of the 2022 NFL preseason. It’s the final slate of games before the regular season kicks off, meaning players are running out of time to make their case to be on their respective team’s 53-man roster in September.

As usual, Betting News has everything you need to know about the upcoming NFL preseason games, including FanDuel Sportsbook’s latest odds as well as our very own predictions.

NFL Preseason Week 3 Odds — Thursday, Aug. 25

Green Bay Packers vs. Kansas City Chiefs Betting Odds

  • Date: Thursday, Aug. 25 @ 8 p.m. ET
  • Spread: Green Bay Packers -3 (-110), Kansas City Chiefs +3 (-110)
  • Total: OVER 36.5 (-110), UNDER 36.5 (-110)
  • Moneyline: Green Bay Packers -160, Kansas City Chiefs +135

Odds are via FanDuel Sportsbook.

Week 3 of the NFL preseason kicks off with a Thursday night battle between two Super Bowl LVII contenders. Having said that, the Green Bay Packers and Kansas City Chiefs will hardly be putting their best foot forward here due to there being no reason to risk a key player getting unnecessarily injured.

Nevertheless, the Packers are still in the middle of a wide receiver competition, which could end up working in their favor if the Chiefs are more passive. I could see Green Bay squeaking out a close win here.

Prediction: Packers 22, Chiefs 18

Best Bet: Packers -3 (-110)

San Francisco 49ers vs. Houston Texans Betting Odds

  • Date: Thursday, Aug. 25 @ 8:15 p.m. ET
  • Spread: San Francisco 49ers -3 (-110), Houston Texans +3 (-110)
  • Total: OVER 41.5 (-110), UNDER 41.5 (-110)
  • Moneyline: San Francisco 49ers -160, Houston Texans +135

Both the San Francisco 49ers and Houston Texans enter this NFL preseason tilt with matching 2-0 records. While both teams have been impressive, the 49ers’ defense showed what they could truly do last week by holding the Minnesota Vikings to only seven points.

I like the 49ers’ depth and coaching more than the Texans, who are due for a dose of reality. Much like the other Thursday matchup, the favorite shouldn’t have any issue covering the 3-point spread on the road.

Prediction: 49ers 24, Texans 16

Best Bet: 49ers -3 (-110)

NFL Preseason Week 3 Odds — Friday, Aug. 26

Buffalo Bills vs. Carolina Panthers Betting Odds

  • Date: Friday, Aug. 26 @ 7 p.m. ET
  • Spread: Buffalo Bills +6 (-110), Carolina Panthers -6 (-110)
  • Total: OVER 42 (-115), UNDER 42 (-105)
  • Moneyline: Buffalo Bills +220, Carolina Panthers -270

Like other contenders, there’s little reason for the Buffalo Bills to use most of their starters this week. Buffalo has already proven its dominance with back-to-back NFL preseason wins, meaning it’s in head coach Sean McDermott’s best interest to give his best players an extra week of rest.

On the other hand, the Panthers likely want to end their season on a high note following a 20-10 loss to the New England Patriots in Week 2. While Carolina will likely have the better roster of the two this week, expect the Bills to keep it close since they’re 10-0 against the spread (ATS) in their last 10 preseason games.

Prediction: Panthers 23, Bills 20

Best Bet: Bills +6 (-110)

Seattle Seahawks vs. Dallas Cowboys Betting Odds

  • Date: Friday, Aug. 26 @ 8 p.m. ET
  • Spread: Seattle Seahawks -3 (-110), Dallas Cowboys +3 (-110)
  • Total: OVER 40 (-105), UNDER 40 (-115)
  • Moneyline: Seattle Seahawks -155, Dallas Cowboys +130

The Seattle Seahawks have experienced an unfortunate start to their preseason, dropping their first two games by a combined score of 59-36. Meanwhile, the Dallas Cowboys are riding high after a rare exhibition victory over the Los Angeles Chargers last week.

Even though the Seahawks have been the worse team, the Cowboys will likely rest most of their starters due to most of their roster spots being set. With Seattle still having ongoing positional battles, especially at QB, chances are the Seahawks will put forth the stronger effort.

Prediction: Seahawks 24, Cowboys 10

Best Bet: Under 40 Points (-115)

Los Angeles Chargers vs. New Orleans Saints Betting Odds

  • Date: Friday, Aug. 26 @ 8 p.m. ET
  • Spread: Los Angeles Chargers +1.5 (-110), New Orleans Saints -1.5 (-110)
  • Total: OVER 36.5 (-115), UNDER 36.5 (-105)
  • Moneyline: Los Angeles Chargers +105, New Orleans Saints -125

Both the Chargers and New Orleans Saints haven’t found luck this NFL preseason, entering the final week with matching 0-2 records. While both teams would love a victory, I’m leaning towards Los Angeles here.

At the end of the day, the Saints’ offense has been non-existent this August, scoring a total of 23 points over two games. While the Chargers have had their fair share of issues, they scored 22 points in Week 1 alone, showing that they can win on Friday as long as the defense doesn’t gift the Saints with any juicy opportunities.

Prediction: Chargers 21, Saints 13

Best Bet: Chargers ML (+105)

New England Patriots vs. Las Vegas Raiders Betting Odds

  • Date: Friday, Aug. 26 @ 8:15 p.m. ET
  • Spread: New England Patriots +1.5 (-110), Las Vegas Raiders -1.5 (-110)
  • Total: OVER 37.5 (-115), UNDER 37.5 (-105)
  • Moneyline: New England Patriots +100, Las Vegas Raiders -120

The Patriots have a tough task in front of them this week as they must stop the 3-0 Las Vegas Raiders. While that task may seem daunting, it’s within the realm of possibility considering that Las Vegas’ three wins were each decided by only one possession.

The game also gives Bill Belichick an opportunity to remind Raiders head coach Josh McDaniels who the master was in their relationship. Though the stakes for this game are low, I could see the Patriots pulling out the victory thanks to Belichick’s having more experience than his counterpart.

Prediction: Patriots 19, Raiders 16

Best Bet: Patriots ML (+100)

NFL Preseason Week 3 Odds — Saturday, Aug. 27

Jacksonville Jaguars vs. Atlanta Falcons Betting Odds

  • Date: Saturday, Aug. 27 @ 3 p.m. ET
  • Spread: Jacksonville Jaguars +3 (-115), Atlanta Falcons -3 (-105)
  • Total: OVER 36.5 (-110), UNDER 36.5 (-110)
  • Moneyline: Jacksonville Jaguars +135, Atlanta Falcons -160

The Jacksonville Jaguars have now dropped back-to-back-to-back NFL preseason games, averaging only 14 points scored in defeat. The thing is that the Jaguars actually amassed 367 total yards against the Pittsburgh Steelers last week, but couldn’t convert when it counted, going just 10-of-20 on third-down attempts.

While the Atlanta Falcons haven’t looked great either, going 3-of-12 on third downs and 1-0f-5 on red-zone attempts during a 24-16 loss to the New York Jets on Monday.

With the Jaguars looking desperate, I think Doug Pederson has what it takes to help his team end the preseason on a high note.

Prediction: Jaguars 21, Falcons 15

Best Bet: Jaguars ML (+135)

Los Angeles Rams vs. Cincinnati Bengals Betting Odds

  • Date: Saturday, Aug. 27 @ 6 p.m. ET
  • Spread: Los Angeles Rams +2.5 (-110), Cincinnati Bengals -2.5 (-110)
  • Total: OVER 37.5 (-110), UNDER 37.5 (-110)
  • Moneyline: Los Angeles Rams +110, Cincinnati Bengals -130

Fans will be treated to a Super Bowl LVI rematch this week without any of the high stakes from February. While the Los Angeles Rams are coming off a 24-20 loss to the Houston Texans last week, the Cincinnati Bengals are 0-2 in their exhibition endeavors.

With neither team likely putting their best foot forward here, I like the Rams winning. The Bengals’ players are much more banged up and Cincinnati hasn’t shown too much promise this August.

In a game that could go either way, I’m taking the over on the total.

Prediction: Rams 24, Bengals 21

Best Bet: Over 37.5 Points (-110)

Washington Commanders vs. Baltimore Ravens Betting Odds

  • Date: Saturday, Aug. 27 @ 7 p.m. ET
  • Spread: Washington Commanders +6.5 (-110), Baltimore Ravens -6.5 (-110)
  • Total: OVER 39.5 (-110), UNDER 39.5 (-110)
  • Moneyline: Washington Commanders +230, Baltimore Ravens -280

This NFL preseason matchup is a tale between two different teams. Not only are the Washington Commanders 0-2 in exhibition action this year, but they’ve lost five of their last six preseason games. It also doesn’t help that they’re also just 2-7 in their last nine trips to Baltimore.

Meanwhile, the Ravens are 2-0 following their 24-17 victory over the Arizona Cardinals last week. Baltimore must be more disciplined after taking 12 penalties for 116 yards last week. Still, the Ravens have the deeper and better roster here, so look for the Commanders’ woes to continue.

Prediction: Ravens 23, Commanders 14

Best Bet: Ravens -6.5 (-110)

Philadelphia Eagles vs. Miami Dolphins Betting Odds

  • Date: Saturday, Aug. 27 @ 7 p.m. ET
  • Spread: Philadelphia Eagles +3.5 (-110), Miami Dolphins -3.5 (-110)
  • Total: OVER 38 (-110), UNDER 38 (-110)
  • Moneyline: Philadelphia Eagles +145, Miami Dolphins -170

The Philadelphia Eagles and Miami Dolphins have had their ups and down this preseason, resulting in each team going 1-1 thus far. The Eagles are the underdog here and while victory is still possible, they’re only 3-10-1 ATS in their last 14 preseason games.

On the other hand, the Dolphins are 8-2 ATS in their last 10 exhibition outings. That’s on top of their being 6-2 straight up in their last eight home games against the Eagles. I think that home-field advantage will play a role here, leading to a Miami victory.

Prediction: Dolphins 19, Eagles 15

Best Bet: Dolphins -3.5 (-110)

Chicago Bears vs. Cleveland Browns Betting Odds

  • Date: Saturday, Aug. 27 @ 7 p.m. ET
  • Spread: Chicago Bears +4.5 (-115), Cleveland Browns -4.5 (-105)
  • Total: OVER 40 (-110), UNDER 40 (-110)
  • Moneyline: Chicago Bears +165, Cleveland Browns -195

The Chicago Bears have been one of the more surprising teams this NFL preseason. They’re 2-0 after two weeks, however, a good portion of their offense is banged up. Even with head coach Matt Eberflus saying his starters will play “25-30 plays” in the first half, it isn’t like they have that much talent to begin with.

Though the Browns aren’t thrilled that they lost to the Eagles last week, it was only by a single point. Cleveland even generated 403 total yards against Philadelphia, with 229 coming on the ground.

I like the Browns, as well as the under for this game.

Prediction: Browns 22, Bears 13

Best Bet: Under 40 Points (-110)

Arizona Cardinals vs. Tennessee Titans Betting Odds

  • Date: Saturday, Aug. 27 @ 7 p.m. ET
  • Spread: Arizona Cardinals +3 (-115), Tennessee Titans -3 (-105)
  • Total: OVER 36 (-110), UNDER 36 (-110)
  • Moneyline: Arizona Cardinals +140, Tennessee Titans -165

The Tennessee Titans’ defensive capabilities were on full display last week with a 13-3 victory over the Tampa Bay Buccaneers. If their defense comes to play right away, they could give Tennessee an early edge since the Cardinals didn’t score 14 of their 17 points against the Ravens last week until the fourth quarter.

It also doesn’t help that the Cardinals are dealing with a slew of injuries. Kliff Kingsbury’s group has hardly been putting their best foot forward and with those injuries, it’ll likely be another subpar performance by Arizona.

Prediction: Titans 19, Cardinals 14

Best Bet: Titans -3 (-105)

Tampa Bay Buccaneers vs. Indianapolis Colts Betting Odds

  • Date: Saturday, Aug. 27 @ 7:30 p.m. ET
  • Spread: Tampa Bay Buccaneers +5.5 (-105), Indianapolis Colts -5.5 (-115)
  • Total: OVER 40 (-110), UNDER 40 (-110)
  • Moneyline: Tampa Bay Buccaneers +200, Indianapolis Colts -240

The Buccaneers’ best players have hardly played in the 2022 NFL preseason and that probably won’t change this week. Between injuries and giving veterans rest, it’ll likely be another bare-bones lineup for the Bucs, who are more interested in the regular season.

Even though the Indianapolis Colts are 0-2, they’ve shown promise. Both of the Colts’ losses were decided by a single possession thanks to their second- and third-string players stepping up.

Again, Tampa Bay likely won’t try hard here, leading to an Indianapolis victory.

Prediction: Colts 27, Buccaneers 17

Best Bet: Over 40 Points (-110)

Minnesota Vikings vs. Denver Broncos Betting Odds

  • Date: Saturday, Aug. 27 @ 9 p.m. ET
  • Spread: Minnesota Vikings -1.5 (-110), Denver Broncos +1.5 (-110)
  • Total: OVER 36.5 (-110), UNDER 36.5 (-110)
  • Moneyline: Minnesota Vikings -120, Denver Broncos +100

The preseason has been tough for the Vikings, who are now 0-2 and only averaging 13.5 points per game. Then you have the Denver Broncos, who followed up their preseason-opening win with a 42-15 loss to the Bills over the weekend.

While Minnesota is the slight favorite here, the Vikings looked terrible last week, generating 195 yards while only holding the ball for about 37% of the game. That just isn’t a good formula to win football games, even in the preseason.

Give me the Broncos pull off the “upset” at home.

Prediction: Broncos 18, Vikings 13

Best Bet: Broncos ML (+100)

NFL Preseason Week 3 Odds — Sunday, Aug. 28

New York Giants vs. New York Jets Betting Odds

  • Date: Sunday, Aug. 28 @ 1 p.m. ET
  • Spread: New York Giants +3 (-110), New York Jets -3 (-110)
  • Total: OVER 38.5 (-110), UNDER 38.5 (-110)
  • Moneyline: New York Giants +135, New York Jets -160

In one of the biggest surprises of August, both the Giants and Jets have had perfect starts to the preseason. Even though the Jets are the favorites here, I could see the Giants scoring the “road” win at MetLife Stadium.

The Jets have penalty issues that need to be ironed out after racking up 104 yards on 11 calls in Week 2. They were also lucky to beat the Falcons after giving up 380 total yards to them, which doesn’t bode well after the Giants dropped 423 on the Bengals.

The game could go either way, though, which is why taking the over is the best bet.

Prediction: Giants 24, Jets 21

Best Bet: Over 38.5 Points (-110)

Detroit Lions vs. Pittsburgh Steelers Betting Odds

  • Date: Sunday, Aug. 28 @ 1 p.m. ET
  • Spread: Detroit Lions +4.5 (-110), Pittsburgh Steelers -4.5 (-110)
  • Total: OVER 38.5 (-110), UNDER 38.5 (-110)
  • Moneyline: Detroit Lions +175, Pittsburgh Steelers -210

The Lions haven’t been able to get much separation from their opponents in the 2022 preseason. Both of their games have been decided by three or fewer points and they’ve been outscored, 53-50, by their opponents.

On the flip side, the Steelers have looked fairly strong, nabbing back-to-back wins. Kenny Pickett, Mason Rudolph and Mitchell Trubisky will likely be given opportunities to win the starting QB job, which should give Pittsburgh the edge assuming that Jared Goff is rested once again.

Prediction: Steelers 27, Lions 22

Best Bet: Over 38.5 Points (-110)

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Devon Platana
Devon Platana