Kansas City Chiefs vs San Francisco 49ers: NFL Predictions, Odds & Best Bets

The NFL is giving us a rematch of last year's Super Bowl as the San Francisco 49ers host the undefeated Kansas City Chiefs at Levi's Stadium this Sunday. All eyes will be on these two teams as they duke it out to see if Brock Purdy and the Niners can enact their revenge on the Chiefs from their last meeting in February.

As I said, the Chiefs are undefeated, but by very slim margins. They are seriously close to being just 2-3 instead of 5-0, and coming off a bye week, I expect Andy Reid to have his boys ready to go in this matchup. No win comes easy in the NFL, and Kansas City knows they have a target on their back. Everyone wants to take down the top dawg. Can the 49ers do that this weekend?

They are still without Star RB Christian McCaffrey, and some of the other offense players are banged up. Jordan Mason, Deebo, and Jauan Jennings are all listed as questionable. Mason and Deebo were limited in practice on Wednesday while Jennings did not see the field at all. Defensively, they also have the injury bug. LB Dre Greenlaw hasn't played a snap, and interior linemen Maliek Collins and Jordan Elliot are both questionable come Sunday. Their starting SS is banged up, and so are both of their kickers.

Will they be able to find enough bodies to beat the Chiefs? Or will Kansas City silence the 49ers again?

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Kansas City Chiefs vs San Francisco 49ers: Super Bowl Rematch

Matchup Information – Chiefs vs 49ers

• Venue & Location: Levi's Stadium (Santa Clara, CA)
• Date: Sunday, October 20th, 2024
• Kick Off: 4:25pm Eastern
• Broadcast: CBS

Betting Odds

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Spread

• Chiefs +1 (-103)
• 49ers -1 (-117)

Money Line

• Chiefs +100
• 49ers -120

Total

• Over 46.5 (-115)
• Under 46.5 (-105)

Can Purdy and 49ers Finally Take Down Mahomes?

Look, I don't need to give you all the stats about Mahomes with a plus sign next to his name, but I'm going to anyways.

As an underdog, Mahomes is 11-1-1 Against the Spread, and 10-3 straight up. More often than not, a bet on Mahomes as an underdog is a winner, but will that be the case this weekend? The 49ers will obviously be fired up to host the Chiefs and get their revenge, but beating Kansas City is one of the hardest things to do in sports at the moment. Brock Purdy has only faced Mahomes in the Super Bowl, but he did come in for some garbage time against the Chiefs back in October of 2022, before taking Jimmy Garoppolo's job a few weeks later.

We also have to factor in the fact that the Chiefs are coming off a bye week. Sure, San Francisco is also off a "mini bye" as they took down Seattle on Thursday Night Football and will have 10 days of rest, but Andy Reid has a fantastic record coming off a bye week. As the head coach of the Chiefs, Andy Reid has an 8-3 record coming off a bye week. That record improves to 5-1 with Mahomes running the offense, with the one loss coming last year to the Eagles.

If you give Reid and the Chiefs enough time to prepare, they probably beat you. No disrespect to Kyle Shanahan and his staff, but Reid, Nagy, and Spags are on a whole different tactical planet, and I see it coming into play this week. I'm not going to sit here and tell you take the Chiefs ML at even money, even though I already bet it at +102. But before I sell you this player prop and you call me a homer, we are 8-0 on bets involving the Chiefs this season.

Kansas City Chiefs vs San Francisco 49ers Best Bets

Chiefs vs 49ers Prediction: Chiefs Win, Under 46.5

Best Bet: Patrick Mahomes Over 4.5 Rushing Attempts (+102) BetOnline

Shoutout to Adam' Digest who turned me in the direction of this prop, and for plus money, I'll take it this weekend. We benefit from Mahomes potentially kneeling down instead of suffering if we took his yards, but I do think 20.5 is a good look in this game. Mahomes has 5+ carries in 3 straight games, and had 4 in the game before that. In the past, he may have been told to be careful and avoid hits, but now he is running fearlessly on defenses who let him out of the pocket, and he's doing whatever it takes to get some extra yards.

Mahomes had 9 carries for 66 yards in the Super Bowl against the 49ers, and dating back to last season has cleared this line in 6 of his L8 games. Now, coming off a bye week, Mahomes is special. He averages 270 passing yards, has 10 TDs and 4 Interceptions in his first game after a bye, and he is especially good on the ground. Mahomes averages 5.33 carries for 34.33 rushing yards following a bye week, clearing this line in 3/6 games and ending with 4 carries twice. He's also been the team's leading rusher in 2 of those games following a bye week, so I wouldn't be surprised to see Mahomes make some plays with his legs. And a kneel down before halftime or to seal the game wouldn't be too bad either.

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