Detroit Mercy vs. DePaul: Odds & Predictions | November 23, 2025

Colby Marchio

Written by: Colby Marchio

Last Update: Sun Nov 23, 2025, 1:51 pm ET

Read Time: 5 minutes

BettingsNews Default Image

ncaab

Detroit Mercy Titans logo
FINAL
DePaul Blue Demons logo

Detroit Mercy Titans

75

DePaul Blue Demons

95
See Picks & Statistics For The Game
DePaul has a simple task this evening. Show that the Gardner Webb performance was not a one night burst, but the start of real momentum. The Blue Demons finally played with purpose in that win. It was the first time this season they looked fully locked in. Now the question is straightforward. Can DePaul replicate what they just did to Gardner-Webb, or was that dominance temporary? This evening provides the perfect chance to prove it was real. Another focused effort would signal growth, stability, and a team starting to trust its identity. It is time to find out.

Get FREE Picks and Props Weekly

Sign up for
THE WEEKENDER NEWSLETTER

Write Up Transparency

Be sure to follow me on X/Twitter @C_marchio2 to get my full card every day! Picks are always FREE.

Last 7 Days: 7-12 (-2.9 Units)

2025-26 Season: 23-25 (-0.25 Units)

Early season woes. Auto fade me? You won't.

Detroit Mercy vs. DePaul Odds

Can DePaul replicate the same dominant effort they delivered against Gardner Webb this evening?

Odds are courtesy of BetOnline, a longtime fixture among the top online sports betting sites. Check out our BetOnline sportsbook review, then bag a big bonus (100% if your first deposit is with Bitcoin, Ethereum, or another cryptocurrency) to bet on College Basketball games.

Spread

Detroit Mercy: +20.5 (-1110)

DePaul: -20.5 (-110)

Total

Over: 152.5 (-116)

Under: 152.5 (-104)

Moneyline

Detroit Mercy: N/A

DePaul: N/A

Detroit Mercy vs. DePaul Best Bet

After snapping their two game losing streak, the DePaul Blue Demons finally took it to Chris Holtmanns former school, Gardner Webb. The Blue Demons won 93 to 62. They should have won that game by 40, but covering the 22.5 point spread also works. Detroit Mercy, on the other hand, is still searching for their first win of the season against a division one opponent. They have lost three straight. Their lone win came against Cleary, where they won 92 to 54. Do the Titans have a chance tonight? Anything is possible.

Keep Your Foot on the Gas

DePaul enters as a 20.5 point favorite this evening. I was able to snag the opening number of 16.5. Do not worry, I still endorse the 20.5. This should be another spot where DePaul goes all out. They have no reason to look ahead to their game on Friday against Georgia Tech in Destin, Florida for the Emerald Coast Classic.

After losing to Buffalo and Northwestern, DePaul can not afford to ease up. They have a fairly easy schedule until they go to Wichita State on December 13, then they are in New York taking on St. Johns. Following that, they host UConn, then go to Villanova before the new year.

Detroit Mercy is currently ranked No. 309 on Bart Torvik, where they have one of the worst offenses in college basketball. They are 25th in three-point percentage, eFG% offense, and free throw rate. On the other end, they struggle with sending teams to the line and they struggle defending the interior and perimeter, ranked in the upper 280s.

DePaul has been great at forcing fouls and getting to the line, but they struggle with making those foul shots. However, Holtmann has made a point to get the guys into Wintrust Arena to get their shots up. I think as the season progresses, their free throw shooting should improve. Again, why are they not practicing at their home arena? Makes no sense. I digress.

The Blue Demons have been running at a much slower pace this season. Haslametrics ranks them 205 in pace, while Detroit Mercy is ranked 102. If DePaul can force the Titans to run at their slower pace, it should throw off Detroit Mercy's rhythm in this game.

With a much tougher schedule ahead, DePaul has no reason to take its foot off the gas. They have already suffered an embarrassing loss to a team inside the 300s and can not afford another blemish. This is a chance to build real momentum, sharpen their identity, and head into a difficult stretch with confidence. They should steamroll the Titans at home this evening.

Sko Mons.

Best Bet: DePaul -20.5 (-110) on BetOnline

Interested in More Content

Follow me on X @C_marchio2 for all of my picks and sports opinions!

Be sure to check out all things Betting News on X and Twitch!

While you are at it go get some merch at our Betting News Store!

In need of a sportsbook? Check out one of our favorites below and sign-up for a bonus!

1
4.9/5 Review Rating
Bonus & Benefits
Up to $1,250 + 50 Free Slots Spins
See our review »
$1,250 Welcome Bonus
Bet Live on Your Favorite Sports
Earn More with Rebel Rewards!
2
4.8/5 Review Rating
Bonus & Benefits
55% Welcome Bonus w/ code BNBOL55
See our review »
Up to $250 in Free Bets + 100 Spins
$10 Cash Bonus w/ Code BNEWS
Fastest Payouts
3
4.7/5 Review Rating
Bonus & Benefits
Get 20% Cashback Weekly
See our review »
10% Daily Cashback
10% Weekly Cashback Every Thursday
Get VIP Rewards for Your Sports Bets
4
4.6/5 Review Rating
Bonus & Benefits
100% up to $1,000 Sign-Up Bonus
See our review »
Bonus Code: WELCOME1000
Monthly Cash Prizes
Vast Lines and Games Selection
5
4.5/5 Review Rating
Bonus & Benefits
55% Welcome Bonus w/ code BNSB55
See our review »
$250 in Free Bets with First Deposit
Same Game Parlays
Frequent Odds Boosters
6
4.4/5 Review Rating
Bonus & Benefits
50% Up to $750
See our review »
Best Prop Bets Selection
Boosted Odds on Parlays
One of the Oldest and Trusted Sites
7
4.3/5 Review Rating
Bonus & Benefits
Multiple Bonuses for New Players
See our review »
125% Promo Bucks Up to $2,500
100% Cash Bonus Up to $2,000
Weekly Rebates!
8
4.2/5 Review Rating
Bonus & Benefits
Deposit $100, Get $50 Free
See our review »
Reduced Juice for Spreads & Totals
Fast Crypto Deposits & Payouts
Winners & High Rollers Welcome!
9
4.1/5 Review Rating
Bonus & Benefits
125% Welcome Bonus
See our review »
Anonymous Crypto Betting
125% Welcome Bonus
Great Live Betting Selection
10
4.0/5 Review Rating
Bonus & Benefits
125% Deposit Bonus
See our review »
Fast & Easy Payouts
Best Deposit & Free Play Bonuses
Largest Selection of Sports & Games

Check Out All of Our Resources at Betting News

See our Matchup - Free Picks & Stats
Colby Marchio
Colby Marchio

Former D1 (club) baseball player, Colby has been betting since his college days at DePaul, where he had to endure the worst collegiate basketball the Big East has ever seen. He is an advanced analytics nerd and has never seen an underdog he has not liked. Hot. Corn. Bull. It does not matter the dog he loves them all.

This site contains commercial content. We may be compensated for the links provided on this page. The content on this page is for informational purposes only. Betting News makes no representation or warranty as to the accuracy of the information given or the outcome of any game or event.