#6 Louisville vs. #25 Arkansas: Odds & Predictions | December 3, 2025

Colby Marchio

Written by: Colby Marchio

Published: Wed Dec 03, 2025, 2:48 pm ET

Read Time: 5 minutes

Can Louisville shoot as well as they did in the Round of 64 against the Spartans? Michigan State Louisville Picks

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Louisville Cardinals logo
FINAL
Arkansas Razorbacks logo

Louisville Cardinals

80

Arkansas Razorbacks

89
See Picks & Statistics For The Game

Tonight's slate features one of the most intriguing matchups of the college basketball season. Louisville travels to take on Arkansas in a game that will reveal exactly what these teams are made of. The Cardinals have cruised through a soft schedule, but tonight is their first true road test against a battle-tested Razorbacks squad. Arkansas has been close to big wins all season, and they are hungry to finally take down a top ten opponent at home. Expect intensity, energy, and a clash of styles as both teams look to make a statement in this must-watch game.

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Last 7 Days: 6-5 (+0.66 Units)

Last 30 Days: 38-33 (+6.19 Units)

#6 Louisville vs. #25 Arkansas Odds

Is tonight the night Arkansas finally takes down a top 10 team?

Odds are courtesy of BetOnline, a longtime fixture among the top online sports betting sites. Check out our BetOnline sportsbook review, then bag a big bonus (100% if your first deposit is with Bitcoin, Ethereum, or another cryptocurrency) to bet on College Basketball games.

Spread

Louisville: -2 (-113)

Arkansas: +2 (-107)

Total

Over: 166 (-105)

Under: 166 (-115)

Moneyline

Louisville: -139

Arkansas: +119

#6 Louisville vs. #25 Arkansas Best Bet

Easily my favorite game on the slate today, win or lose my bet, this is where you will find out what both of these teams are made of. Most importantly Louisville, who has endured the 23rd easiest schedule up to this point. Sure, they took down Kentucky, but at this point in time, that is not saying much. Meanwhile, the Razorbacks have been so close to knocking off some of the best teams in the country. They are covering, but they have not been beating these top teams. They feel more than due for a big win.

Hog Season

That is why I am forced to take the Razorbacks on the spread this evening. A home underdog that has been playing very good basketball this season, give me the home town team.

I have been a fan of this team since their three-point loss to Michigan State on the road early in the season. They then kept it close for most of the game against Duke on Thanksgiving, and I think tonight is where they finally get over the hump at home and take down a top ten opponent. The Razorbacks have been excellent on both ends, ranked inside the top 30 in both. They protect the basketball very well, make their free throws at a high rate, and do not send their opponents to the line. This is a very underrated basketball team.

Meanwhile, on the other side, the Cardinals will be entering their first true road test this evening. They have also benefited from taking on four teams ranked 224 or greater this season. Of the two teams inside the top 100 that they have played, one was Kentucky, which we have established is not as good as they should be at this moment, and the other was Cincinnati, who they beat by ten on a neutral court. I need to see it tonight from this Louisville team. Sure, they have looked special and their stats reflect a well-rounded team. However, they have yet to actually play anyone in my opinion. Nobody as good as the teams Arkansas has faced, and that is why I have to roll with the more battle-tested home underdog in this one.

Line Movement

The line has moved slightly since opening at +3.5, where I snagged the Hogs. I still endorse the +2 because I truly believe they will win this game. I always take the points when there is a cushion. It is college basketball, anything can happen, so I lean with the points even if it is +1.5. For the total, I am leaning over. Both teams like to run, and both offenses should show up in this one.

However, tonight is where the Razorbacks prove themselves. They are battle-tested, disciplined, and ready to take down a top ten opponent at home. Louisville faces their first real road test, and I expect Arkansas to capitalize. Take the home underdog with confidence and enjoy what should be an exciting contest.

Best Bet: Arkansas +2 (-107) on BetOnline

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Colby Marchio
Colby Marchio

Former D1 (club) baseball player, Colby has been betting since his college days at DePaul, where he had to endure the worst collegiate basketball the Big East has ever seen. He is an advanced analytics nerd and has never seen an underdog he has not liked. Hot. Corn. Bull. It does not matter the dog he loves them all.

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