#22 St. John’s vs. DePaul: The DePaul Report | February 3, 2026

Colby Marchio

Written by: Colby Marchio

Last Update: Tue Feb 03, 2026, 2:25 pm ET

Read Time: 4 minutes

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St. John's Red Storm logo
FINAL
DePaul Blue Demons logo

St. John's Red Storm

68

DePaul Blue Demons

56
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Rick Pitino and No. 22 St. John's head to Chicago for a tough road test against a DePaul team that continues to play its best basketball at Wintrust Arena. This is the second meeting between these programs, with the Red Storm winning 79 to 66 in Queens back on December 16. Despite that result, DePaul has been one of the most reliable teams against the spread in conference play and thrives at home. Coming off a blown lead against Xavier, the Blue Demons should be motivated and locked in, setting the stage for a competitive Big East battle.

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#22 St. John's vs. DePaul Odds 

Zuby Ejiofer and St. John's look to extend their winning streak tonight at Madison Square Garden - Seton Hall St. John's Picks

How will the Red Storm handle the Blue Demons on the road?

You can find all of these great College Basketball odds on Lucky Rebel. Get a $1,250 deposit bonus & 50 Slot Spins when you sign up!

Spread

St. John's: -9.5 (-110)

DePaul: +9.5 (-110)

Total

Over: 147.5 (-110)

Under: 147.5 (-110)

Moneyline

St. John's: -500

DePaul: +425

#22 St. John's vs. DePaul Bet

Boots will be grounded for the third straight year in the presence of basketball royalty, as Rick Pitino and No. 22 St. John's Red Storm head to the South Loop of Chicago to take on a very underrated DePaul Blue Demons team.

This will be the second and final regular season meeting between these two programs. The first matchup took place in Queens on December 16, when the Red Storm defeated the Blue Demons 79 to 66, failing to cover the closing 19.5-point spread. Now, St. John's finds itself as a 9.5-point road favorite. Are the books giving DePaul too much respect in this spot? After blowing a late lead to Xavier on Saturday, can the Blue Demons keep this one close against St. John's?

Trust the Mons?

Yes. Yes, they can. The Blue Demons have been relentless in conference play and continue to be one of the most profitable teams at the window. While they sit at 4-7 straight up, they are an impressive 9-2 against the spread. Most importantly, DePaul plays its best basketball inside Wintrust Arena. Haslametrics grades the Blue Demons as the 50th best team at home, while St. John's ranks just 21st in road games.

Erik Haslam states, "St. John's has performed far better away from home this year than they have at home. Unfortunately for them, they face DePaul, who has played their very best basketball this season in front of their home crowd."

At home, DePaul owns the 50th best defense in the country and excels at protecting the interior, ranking 20th in two-point percentage defense. While the Blue Demons have struggled at times defending the three, they still rank 44th in three-point rate defense. That pairs well against a Red Storm team that ranks 316th in three-point rate on the road.

On the offensive end, DePaul is one of the best teams in the country at getting to the free throw line. They also rank 151st in three-point percentage and eighth in assist rate. That sets up nicely against a St. John's defense that, away from home, ranks fifth worst in three-point percentage defense, 281st in effective field goal percentage defense, and 183rd in free throw rate defense.

With the Blue Demons coming off an 18-point collapse against Xavier on Saturday, now returning home, this feels like a team ready to respond. Expect DePaul to play with a chip on its shoulder and keep this one within the number.

Best Bet: DePaul +9.5 (-110) on Lucky Rebel

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Colby Marchio
Colby Marchio

Former D1 (club) baseball player, Colby has been betting since his college days at DePaul, where he had to endure the worst collegiate basketball the Big East has ever seen. He is an advanced analytics nerd and has never seen an underdog he has not liked. Hot. Corn. Bull. It does not matter the dog he loves them all.

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