MLS Picks and Predictions for July 22, 2026

Nate Hornung

Written by: Nate Hornung

Published: Wed Jul 22, 2026, 10:10 am ET

Read Time: 5 minutes

Timothy Tillman and LAFC take on Real Salt Lake at home tonight in the MLS - MLS Picks

MLS

We have a FULL slate of MLS action tonight. Every single team in Major League Soccer takes the pitch, as we have a 15 match schedule for Wednesday. Let's be honest, trying to find a bet in every match could distract us from some actual edges. Therefore, we are going to keep the betting card smaller, and focus in on our favorite MLS picks for Wednesday. Tap in below!

  • MLS YTD
  • 22-18-1 (55%)
  • +5.36u
  • Average Odds: +120

Head over to our MLS Picks Page for our expert's soccer analysis, or read my best bets below.

Major League Soccer: Wednesday's Predictions July 22

Nashville SC vs. CF Montreal MLS Picks

After recovering from injury, Sam Surridge was back in action for Nashville prior to the World Cup break - MLS Picks

After recovering from injury, Sam Surridge was back in action for Nashville prior to the World Cup break

Best Bet: Nashville SC/Under 4.5 (-102) Lucky Rebel Sportsbook

Here we go again backing Nashville at home to win a low scoring match. Nashville is unbeaten at home so far this season, posting a 7-1-0 record at GEODIS Park through eight matches. I have very little faith in Montreal making some noise offensively, and I endorse Nashville to win via shutout as well at +170. Montreal just played Toronto to a scoreless draw in their first match back from the break, now they head on the road where they have struggled this season.

They are 1-1-6 away from home this season, being shutout three separate times. Tonight they face the top team in the Eastern Conference, and I think Nashville wins an easy one on their home soil. Let's hope it doesn't get too ugly, but taking this same game parlay down to 3.5 total goals for +153 could also be a move in this match.

Prediction: Nashville Wins 2-0 (+725)

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LAFC vs. Real Salt Lake MLS Picks

LAFC and Real Salt Lake battle in Los Angeles tonight. Will leading goal scorer, Denis Bouanga, find the back of the net? - MLS Picks

LAFC and Real Salt Lake battle in Los Angeles tonight. Will leading goal scorer, Denis Bouanga, find the back of the net?

Best Bet: LAFC ML/Under 4.5 (+127) Lucky Rebel Sportsbook

LAFC started out this MLS season as one of the best on both sides of the ball, especially defensively. Since the first seven matches or so, they have certainly cooled off. But coming out of the World Cup break, I think this team is ready to roll, and they already showed how dominant they can be. LAFC took down the LA Galaxy on the road, beating them 3-0 last Friday night.

Both of these teams tonight are solid defensively, allowing in between 1.06 and 1.36 goals per match. On the flip side, neither team is scoring more than two per match either. I see LAFC locking in defensively, just like they did against the Galaxy. It will certainly be tough to score, but I think they are better equipped to find one in a match where goals come at a premium.

Ironically, I do see both teams finding the back of the net, but even if that happens, LAFC can squeak out a 2-1 win at home.

Prediction: LAFC Wins 2-1 (+700)

San Jose Earthquakes vs. Orlando City MLS Picks

Best Bet: San Jose ML/Under 4.5 (+143) Lucky Rebel Sportsbook

I am putting some huge trust into the Orlando City back line tonight on the road against San Jose. The Earthquakes are near the top of the Western Conference, netting 2.27 goals per match while allowing one, and Orlando is scoring just 1.53 while conceding nearly three per match. But tonight I think they hold their own. I don't expect them to contribute offensively, but we don't need them to.

In seven home matches, this parlay would've cashed three times. They have three home shutouts under their belt, and facing a team with virtually no offense will be ideal. Overall, San Jose is simply the stronger team here, and I'll back them to win a low scoring match at home.

Prediction: San Jose Wins 2-0 (+1000)

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Nate Hornung
Nate Hornung

Nate has been a recreational sports bettor for about 5 years. In that time, he has grown to love the pursuit of winners and sticking it to The Man. Nate loves data and uses his understanding of numbers to help him be a more profitable sports gambler, however he will be the first to tell you this game is about more than just stats.

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