CBS Sports

Dratings

DunkelIndex

OddsShark

Sports Betting Dime

Moneyline

Total

Point Spread

Away/Home

Wins

Ov / Un

Avalanche

Ryan Hofer

Jack O'Brien

Andrei Buyalsky

Shane Bowers

Nils Aman

Nazem Kadri

Tyson Jost

Matthew Stienburg

Jayson Megna

Alex Newhook

Stefan Matteau

Colby Ambrosio

Jean-Luc Foudy

Matej Kaslik

Nathan MacKinnon

Callahan Burke

Gabriel Fontaine

Artem Anisimov

Nico Sturm

Andrew Cogliano

Ben Meyers

Jacob MacDonald

Devon Toews

Ryan Murray

Roland McKeown

Mitchell Smith

Cale Makar

Graham Sward

Nicolas Savoie

Sergei Boikov

Jordan Gross

Drew Helleson

Bowen Byram

Keaton Middleton

Danila Zhuravlyov

Erik Johnson

Rhett Rhinehart

Dennis Gilbert

Samuel Girard

Justin Barron

Nate Clurman

Sean Behrens

Nick Leivermann

Jack Johnson

Andreas Englund

Josh Manson

Trent Miner

Jonas Johansson

Hunter Miska

Shamil Shmakov

Justus Annunen

Pavel Francouz

Darcy Kuemper

Jett Alexander

Kiefer Sherwood

Kurtis MacDermid

Andre Burakovsky

J.T. Compher

Artturi Lehkonen

Darren Helm

Gabriel Landeskog

Tyler Weiss

Mikhail Maltsev

Andreas Wingerli

Sampo Ranta

Taylor Makar

Dalton Smith

Nikolai Kovalenko

Logan O'Connor

Mikko Rantanen

Oskar Olausson

Nicolas Aube-Kubel

Martin Kaut

Valeri Nichushkin

Alex Beaucage

Nick Henry

Dylan Sikura

Tarun Fizer

Blues

Logan Brown

Sam Anas

Robert Thomas

Oskar Sundqvist

Zachary Bolduc

Tyler Bozak

Brayden Schenn

Tanner Kaspick

Nolan Stevens

Dakota Joshua

Jordan Kyrou

Dylan Peterson

Nathan Todd

Ivan Barbashev

Ryan O'Reilly

Matthew Peca

Klim Kostin

Nikita Alexandrov

Keean Washkurak

Justin Faulk

Steven Santini

Colton Parayko

Calle Rosen

Tyler Tucker

Andrei Pervyshin

Torey Krug

Jake Walman

Noah Beck

Scott Perunovich

Marco Scandella

Niko Mikkola

Tommy Cross

Matthew Kessel

Tyson Galloway

Robert Bortuzzo

Leo Loof

Josh Wesley

Griffin Luce

Nick Leddy

Jordan Binnington

Colten Ellis

Joel Hofer

Will Cranley

Konstantin Barulin

Charlie Lindgren

Vadim Zherenko

Ville Husso

Kyle Konin

Jon Gillies

Jake Neighbours

Mackenzie MacEachern

Pavel Buchnevich

Hugh McGing

Brandon Saad

David Perron

Nathan Walker

Kyle Clifford

Dimitri Semin

James Neal

Evgeny Skachkov

Vladimir Tarasenko

Mathias Laferriere

Simon Robertsson

Alexei Toropchenko

Victor Alexandrov

Ivan Vorobyov

Michael Frolik

Away/Home Defense

Away/Home Offense

Defense

Offense

Colorado Avalanche vs St. Louis Blues Picks

Enterprise Center

<p>The Avalanche will be in St. Louis to take on the Blues in Game 4 of their second round series. They hold a 2-1 lead in the series after downing the Blues on the road in Game 3.</p>
<p>The Blues’ goaltender, Jordan Binnington, left less than seven minutes into the first period in Game 3. He was diagnosed with a knee injury and will not be able to return in the series.</p>
<p>Instead, St. Louis will rely on Ville Husso to get them through the second round. He stopped 19 of 23 shots in Game 3 and could not quite do enough to keep his team in the running.</p>
<p>Colorado got their best offensive production from Artturi Lehkonen who scored twice in their last game. They rebounded well after their Game 2 loss and have the series where they want it heading into Game 4.</p>
<p>According to <a href="https://affiliates.bettingnews.com/register/bovada/">Bovada Sportsbook</a>, the Avalanche are the favorite for a victory on the road. The Blues will try and adjust with a new goaltender to tie the series back up before returning to Colorado.</p>
<h2 id="e6pk3">Colorado Avalanche vs. St. Louis Blues Betting Odds and Matchup Information</h2>
<h3 id="6aae7">Matchup Information</h3>
<ul>
<li>Colorado Avalanche (2-1-0) vs St. Louis Blues (1-2-0)</li>
<li>Venue: Enterprise Center (St. Louis, MO)</li>
<li>Date: Monday, May 23, 2022</li>
<li>Time: 9:30 p.m. ET</li>
<li>How to Watch Avalanche vs Blues Game 4: TNT</li>
</ul>
<h2 id="c4fq2">Avalanche vs. Blues Game 4 Odds</h2>
<p><em><strong>Avalanche vs. Blues odds are via our top reviewed and <a href="/best-online-sportsbooks/">recommended sportsbooks</a>.</strong></em></p>
<h3 id="9blvt"><strong>BetOnline</strong></h3>
<ul>
<li><strong>Puck Line: </strong>Avalanche -1.5 (+150), Blues +1.5 (-182)</li>
<li><strong>Over/Under: </strong>Over 6.5 (-114), Under 6.5 (-106)</li>
<li><strong>Moneyline: </strong>Avalanche -160, Blues +130</li>
</ul>
<h3 id="7o5m1">Bovada Sportsbook</h3>
<ul>
<li><strong>Puck Line: </strong>Avalanche -1.5 (+150), Blues +1.5 (-175)</li>
<li><strong>Over/Under: </strong>Over 6.5 (-115), Under 6.5 (-105)</li>
<li><strong>Moneyline: </strong>Avalanche -160, Blues +140</li>
</ul>
<h3 id="1p0rb">BetUS</h3>
<ul>
<li><strong>Puck Line: </strong>Avalanche -1.5 (+155), Blues +1.5 (-186)</li>
<li><strong>Over/Under: </strong>Over 6.5 (-118), Under 6.5 (+100)</li>
<li><strong>Moneyline: </strong>Avalanche -165, Blues +140</li>
</ul>
<h2 id="c7eab">Trends for Game 4</h2>
<p>For the Blues, Ryan O’Reilly has points in 7 straight games. He has 6 goals and 4 assists in that span and is leading the Blues’ offense.</p>
<p>For the Avalanche, Gabriel Landeskog has points in every game of Round 2. He has tallied 2 goals and 2 assists against the Blues and looks to continue the streak into Game 4.</p>
<p>The Over 1.5 goals in the first period has hit in 7 of the last 8 games following a Blues’ loss. After their loss in Game 3, this trend has a chance to hit again. It currently sits at -162 at <a href="https://affiliates.bettingnews.com/register/betus/">BetUS</a> and is an option as a prop bet for this game.</p>
<p>The Avalanche have won their last 8 games following a road win. They will have to follow their last road win with another tough road test in Game 4, but with their offense clicking and a backup goaltender in for St. Louis, they will be the team to watch.</p>
<h2 id="ejnp">Avalanche vs Blues Prediction and Best Bets</h2>
<p><strong>Avalanche vs. Blues Prediction: </strong>Avalanche 4 Blues 2</p>
<p><strong>Avalanche vs. Blues Best Bets: </strong>Avalanche -1.5 (+150 at <a href="https://affiliates.bettingnews.com/register/betonline/">BetOnline Sportsbook</a> and <a href="https://affiliates.bettingnews.com/register/bovada/">Bovada Sportsbook</a>)</p>
<p>The Avalanche will be tough to stop in Game 4. They will face the #2 goaltender for the Blues, and their offense will be lead by streaking players who are finding success against St. Louis. Expect an offensive show with lots of shots on goal. Winning by 2 goals is a good bet for Colorado, and with it at +150 the return is great.</p>
<p><script>if(window.strchfSettings === undefined) window.strchfSettings = {};window.strchfSettings.stats = {url: "https://betting-news.storychief.io/en/avalanche-vs-blues-2022-game4-odds-prediction?id=1973917239&type=2",title: "Avalanche vs. Blues Game 4 Odds and Prediction: Avs to Extend Series Lead on the Road",id: "4af471aa-0a59-40f0-a023-eeb51e59464b"};(function(d, s, id) {var js, sjs = d.getElementsByTagName(s)[0];if (d.getElementById(id)) {window.strchf.update(); return;}js = d.createElement(s); js.id = id;js.src = "https://d37oebn0w9ir6a.cloudfront.net/scripts/v0/strchf.js";js.async = true;sjs.parentNode.insertBefore(js, sjs);}(document, 'script', 'storychief-jssdk'))</script></p>

Avalanche vs. Blues Game 4 Odds and Prediction: Avs to Extend Series Lead on the Road

Avalanche vs. Blues Game 4 Odds and Prediction: Avs to Extend Series Lead on the Road

Nicholas Plowfield

More NHL News

NHL Best Bet 12/4/2025

NHL Best Bet 12/2/2025

NHL: Capitals vs. Islanders Picks and Odds | November 30, 2025

NHL Best Bet 11/26/2025

NHL: Bruins vs. Islanders Picks and Odds | November 26, 2025