NFL Week 6 Staff Picks: Best Bets & Props from our NFL Staff
Written by: Daniel Collins
Last Update: Sun Oct 18, 2026, 12:26 am ET
Read Time: 9 minutes
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Welcome to Week 6!
There are some fantastic matchups on this Sunday slate in Week 6 and lots of money to be made.
Below, our Team here at Betting News is going to give their BEST BETS for the Week 6 NFL Slate. Whether it is a Spread, Moneyline, Total or Player Prop, this is your go to article every week for our team's favorite bets!
Here is the Squad's Record so far this season.
Season Results: 29-44 of All Picks -120 or better odds
Daniel Collins (SPJ): 2-3
Chef T: 2-3
Nate Hornung (Shaggy): 1-2
Varun Sharma (Sauce): 0-5
Brad Blakemore (Betzky): 1-4
Tristan Vieira (Trizzy): 4-1
Sukh Brar: 1-4
Justin Carlucci: 2-3
PJ Glasser: 2-3
Tones Takes: 2-3
Betting the Pitch: 3-2
BetAlytics: 1-4
Brandon Pham: 3-2
Alex Bohling: 4-1
Jackson McNeese: 1-4
The plays will be tracked weekly right here for you to follow along!
Now let's dive in to the Betting News Squad's Best Bets for NFL Week 6!
All Odds available at Lucky Rebel, the industry leader in the Sports betting Market.
Daniel Collins (SPJ) NFL Week 6 Best Bet (2-3)
Nico Collins should FEAST on the Jaguars
Nico Collins o69.5 Receiving Yards (-115)
Start the Sunday bright and early in London Town with some cash from Nico. Collins absolutely FEASTS on the Jaguars, with 100+ receiving yards in 5 straight matchups with their division foe. The Jags are also DEAD LAST in receiving yards allowed to the WR position this season.
I like a BIG performance from Nico in Jolly Old England to Kick off the Sunday.
Chef T NFL Week 6 Best Bet (2-3)
Tetairoa McMillan o64.5 Receiving Yards (-115)
Really like Tetairoa McMillan tomorrow, he's cleared 75 receiving yards in 3 of 4 games this season and is coming off a monster 192 yard, 2 TD performance against Detroit. Carolina is fresh off a bye, Philly plays nearly 80% zone, and Tet has been eating against that coverage all year.
Give me Tet for 64.5 yards easy.
Nate Hornung NFL Week 6 Best Bet (1-2)
Rams -12.5 -110
Los Angeles has looked solid in exactly one game this year, against the Giants in a 28-6 win at home.
Now they host another terrible team, with a total set at 51.5. I'm leaning into their being plenty points, especially from the Rams, certainly enough to win by two touchdowns.
Arizona has suffered three double digit losses this year. They already won at SoFi against LAC, but they'll lose in dramatic fashion to the Rams this Sunday.
Varun Sharma NFL Week 6 Best Bet (0-5)
Jalen Coker o57.5 Receiving Yards (-105)
The Panthers will head to the City of Brotherly Love to take on the beat up Eagles and what's left of this offense.
The Eagles rank 2nd last in yards allowed to receivers out of the slot, they've given up 5 touchdowns to the slot and they've just struggled to cover the position in general.
Cooper DeJean is taking all of the Eagles snaps in the slot and he's been bad. He's been targeted 26 times, allowing 17 catches for 206 yards and 3 touchdowns. He's allowing a passer rating of 112.3 when targeted and I don't see why that would change this week.
Coker's taking 45% of his snaps in the slot this year, he's 8th in the NFL in terms of separation this year and 13th in route win rate. He's been elite at all levels this year and the Panthers couldn't be more excited to have him back.
Brad Blakemore NFL Week 6 Best Bet (1-4)
Tet McMillan is in a great matchup in Philly this week
Tetairoa McMillan o64.5 Receiving Yards (-115)
Tet is averaging 92 receiving yards per game this season. And we get a discount on the perceived toughness of the Eagles defense. But Parker Washington and Puka just had over 120 yards against the Eagles and the Big Bully wideout for the Panthers could be the third receiver to put up big numbers in a row.
Tristan Vieira NFL Week 6 Best Bet (4-1)
Saints ML (-110)
Giants are coming off an emotional overtime "tie" that most certainly felt like a win to take on the struggling Saints. Despite starting the season hot with 2 upset wins, the Saints have now lost 3 straight and look to right the ship against a Winston led Giants team.
I expect regression on the offensive side for the Giants and even if they keep this game close, I trust Shough to run away with it in the end to break the losing skid.
Sukh Brar NFL Week 6 Best Bet (1-4)
Buccaneers ML (+121)
Listen, I'm 1-4 and so are the Buccaneers. We move to 2-4 together or we go to 1-5 together.
No but in all seriousness, The Bucs defence has looked legit at times, and the Steelers have trouble outside of Pennsylvania.
Rodgers and company are 0-2 on the road this year & 2-6 in their last 8 dating back to last year.
Fire. The. Cannons.
Justin Carlucci NFL Week 6 Best Bet (2-3)
Kendrick Bourne over 35.5 Receiving yards (-114)
Bourne runs nearly three-quarters of his routes from the slot, and the Rams have allowed a 30.8% target percentage to slot receivers, a top-10 mark.
The Cards are huge dogs, and the negative game script should help. Feather in the cap: MHJ is out of the equation now.
PJ Glasser NFL Week 6 Best Bet (2-3)
Can JD5 surprise on MNF?
Commanders +7.5 (-110)
This is my upset of the week. After last weeks late game debacle everyone has been dunking on Washington all week. Expect a great effort from the Commanders and for SF to have a little letdown after a huge Divison win at Seattle.
Take Washington plus the points and outright.
Tone's Takes NFL Week 6 Best Bet (2-3)
Tyler Higbee over 32.5 Receiving yards (-114)
Higbee has taken over as the main TE target since Ferguson went down. He's cleared this mark easily in three straight games and has received 18 targets in that timeframe.
Arizona is allowing the fifth most receiving yards to TEs. The Rams are off a loss and should have no issue putting up yards and points here.
Betting the Pitch NFL Week 6 Best Bet (3-2)
Packers TT o26.5 (-120)
This is expected to be one of the fastest-paced games of the weekend. Dallas has allowed 27 or more points in three of its five games this season. In the other two, the Cowboys surrendered 20 to the Commanders and 24 to a Bucs team led by an undrafted rookie quarterback at Jerry's World.
Now, Dallas heads to Lambeau Field for Sunday Night Football to face a Green Bay offense coming off a 31 point, 367-yard passing performance with two of their WR's going over the 100 yard mark. The Packers should have plenty of opportunities against what has been one of the worst secondaries in the NFL this season. Under the lights at Lambeau, I expect Green Bay to take full advantage of this matchup. Give me the Packers to run up the score at home on SNF!
BetAlytics NFL Week 6 Best Bet (1-4)
Panthers/Eagles Over 38.5 (-115)
Betalytics simulation projects a 23–23 game, 46 combined points and 7.5 above the posted total, and gives the Over a 71.1% chance, the widest gap on the Week 6 slate. Carolina's four games this season have totaled 96, 37, 39 and 58 points, with the Panthers scoring 30.3 per game and allowing 27.3. Philadelphia's five games have landed at 46, 44, 34, 44 and 36, 6/9 combined games between the two teams have cleared 38.5.
Brandon Pham NFL Week 6 Best Bet (3-2)
Isaiah Likely o51.5 Receiving Yds (-114)
Quickly becoming one of Jameis Winston's favorite targets and actually having a larger target share than Malik Nabers at 29.4%.
This week he gets a favorable matchup vs Saints who struggle to cover the TE, ranking 26th in yards allowed against them. They also struggle to defend the sticks, which is where Likely usually operates.
Alex Bohling NFL Week 6 Best Bet (4-1)
Can Josh Allen lead another big time performance for the Bills in Sin City?
Buffalo Bills -4.5 (-110)
The Las Vegas Raiders showed us that they can beat up on teams that are dumpster fires, but when they play teams with actual competence, they fall apart.
The Bills have showed us that they can beat Super Bowl caliber teams. Coming off a massive overtime win against the Rams, I expect them to keep the momentum going.
The Raiders fall off is inevitable and they are likely going to do Raider things we have seen in previous seasons.
Jackson McNeese NFL Week 6 Best Bet (1-4)
Saints/Giants u45.5 (-110)
Both teams have very suspect offenses. The tape is out on both and each team knows what they're getting. Saints defense has dropped their level but I think a get right spot is in store for them here.
Enjoy NFL Week 6!
You can also check out more free picks & analysis from every NFL Week 6 Matchup!
More NFL News
NFL Betting News
NFL Week 6 — Red Zone Report
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Daniel Collins is a sports fanatic and data-driven bettor. He has expertise in the NFL, NBA, and NHL. He’s a big fan of the Titans #titanup, Predators #predators and Arsenal #coyg. If he isn’t watching, betting on or writing about sports, he loves the outdoors, traveling, strong coffee and delicious food. You can follow him on X @SweatpantJesus. Peace and Love
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