Bills vs Dolphins Week 3 Betting: Back Buffalo, the Over in Miami

Devon Platana

Written by: Devon Platana

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Bills vs Dolphins Week 3 Betting: Back Buffalo, the Over in Miami cover


We’ve already hit Week 3 of the 2022 NFL season and another slate of exciting matchups to anticipate. One of the highlights of the week is a collision between two AFC East rivals as the Buffalo Bills pay a visit to the Miami Dolphins on Sunday.

The Bills continued their dominance against the Tennessee Titans on Monday night, exiting with the one-sided 41-7 win. All-Pro wide receiver Stefon Diggs dazzled the hometown crowd in attendance, hailing in 12 balls for 148 yards and a trio of touchdowns.

The Dolphins were involved in one of the more exciting Week 2 games. Down 21 points in the fourth quarter, Mike McDaniel’s squad battled back for the 42-38 victory against the Baltimore Ravens. Wideouts Jaylen Waddle and Tyreek Hill did most of the damage, combining for 22 receptions, 361 yards and four TDs.

Betting News has gathered the latest Bills vs Dolphins odds from BetOnline Sportsbook to help shed some light on the situation, along with a prediction and best bets for the NFL Week 3 game.

Buffalo Bills vs Miami Dolphins Week 3 Matchup Information and Betting Odds

Matchup Information

  • Matchup: Buffalo Bills (2-0, 1-0 Away) vs. Miami Dolphins (2-0, 1-0 Home)
  • Venue & Location: Hard Rock Stadium (Miami Gardens, Florida)
  • Date: Sunday, Sept. 25, 2022
  • Game Time: 1 p.m. Eastern Time
  • Bills vs Dolphins Info: CBS, NFL+

Bills vs Dolphins Odds

Game odds are via BetOnline as of Tuesday, Sept. 20 at 8:30 a.m. ET. Odds from other top online sportsbooks may also be mentioned in this article.


  • Buffalo Bills -6 (-106)
  • Miami Dolphins +6 (-114)


  • Over 52.5 (-110)
  • Under 52.5 (-110)


  • Buffalo Bills -245
  • Miami Dolphins +200

Bills vs Dolphins Betting Trends

  • Buffalo is 7-0 straight up in its last seven games against Miami.
  • Miami is 7-0 straight up in its last seven home games.
  • Buffalo is 4-1 against the spread (ATS) in its last five games.
  • Miami is 3-6-1 ATS in its last 10 games against Buffalo.
  • The total has hit the over in 13 of Buffalo’s last 19 road games.
  • The total has hit the over in 10 of Miami’s last 14 games against Buffalo.

Buffalo Bills vs Miami Dolphins Prediction and Picks

Bills vs Dolphins Prediction: Bills 42, Dolphins 28

Bills vs Dolphins Picks: Bills -6 (Best Value: -106 at BetOnline) & Over 52.5 Points (Best Value: -110 at BetOnline)

After the offensive displays that the Bills and Dolphins produced last week, fans should expect to see a potential shootout on Sunday. Besides, the total has hit the over in 10 of the last Buffalo-Miami matchups.

As mentioned before, the Bills have won seven straight games against the Dolphins. Buffalo hasn’t had any issue putting up points in those previous matchups, averaging 36.8 points over that stretch.

Even if the Dolphins made some offseason improvements, their defense was nearly non-existent last week, surrendering 38 points to the Ravens. Yes, Miami left Baltimore with the victory in the end, but that performance still proves that it could be a long day against a Buffalo team averaging 36 PPG this season.

Both of the Bills’ first two wins have been blowouts against solid teams. First, they absolutely destroyed the defending Super Bowl Champions, the Los Angeles Rams, before absolutely shutting down Derrick Henry and the Titans.

I do think the receiving duo of Hill and Waddle will give the Bills their biggest test of the year, but Buffalo has enough weapons of its own to battle back — especially if WR Gabriel Davis is healthy enough to play this week.

At the end of the day, I have too many questions about Miami’s defense to trust the unit. It couldn’t contain a mobile quarterback like Lamar Jackson and now they have another tough test against Bills gunslinger Josh Allen, who hasn’t lost to the Dolphins since December 2018.

I recommend taking the Bills on the spread here. While six points can be a lot for some teams to cover, Buffalo has won its last seven games by an average margin of 19.2, defeating Miami by at least seven points on six of those occasions.

Having said that, I’m also backing the over on the 52.5-point total. We’ve already seen what the Bills offense can do and with the Dolphins likely playing from behind, Tua Tagovailoa will throw the ball often, creating plenty of scoring chances in the process.

Regardless of who walks out the victor, fans and bettors alike should expect a thrilling game from these two AFC East rivals.

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Devon Platana
Devon Platana

Devon is a Master of Journalism graduate who joined the sports betting world in 2020. His favorite leagues to cover are the NHL, NBA and NFL, and has a soft spot for fantasy football specifically. Outside of sports, he enjoys the finer things in life like pasta, live music and getting even more tattoos.

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