Brewers vs. Padres: Strikeout Props | September 22, 2025
Written by: Colby Marchio
Published: Mon Sep 22, 2025, 1:41 pm ET
Read Time: 5 minutes
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Brewers vs. Padres: October baseball is creeping closer, but before the postseason begins there are still edges to be found in the final weeks of the regular season. Teams are clinching divisions, others are fighting for playoff positioning, and a few are just trying to play spoiler. These late-season dynamics often create the type of betting opportunities that go beyond numbers on a stat sheet. Motivation, travel schedules, celebrations, and letdowns all play their part, and if you can spot the right angle, the value is there for the taking.
One matchup on tonight's slate stands out above the rest. It features a team that spent Sunday afternoon popping champagne bottles and another club still clawing for its division crown. When those two collide, there is one prop in particular that has my full attention. Scroll down, because this is exactly the kind of spot that sharp bettors wait all year to attack.
For additional information on picks, props, moneylines, and more on today's slate, take a look at our MLB Picks Page or our MLB Odds Page, here.
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Brewers vs. Padres Best Bets – September 22
Can Nick Pivetta shut down the Brewers tonight at home?
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Sunday afternoon, the Milwaukee Brewers won the NL North for the third straight year after a 5-1 loss to the Cardinals in St. Louis. Following their division-clinching celebration, they immediately boarded a plane and headed to San Diego. I am normally not a narrative bettor when it comes to baseball, but when a team throws a massive party the night before, celebrating what is essentially the end of their regular season, I want to fade them any way I can.
Which is why I am all over Padres starter Nick Pivetta's strikeout prop this evening. The number is set at 4.5 and priced at $1.60. Some may not like the price, but I will have other props later that you can parlay for plus money, or you can push the line to 5.5 and grab +110. The juice does not bother me in this spot.
Hangovers vs. Pivetta
Pivetta has averaged over 6.5 strikeouts at home all year and gets a lineup that partied hard less than 24 hours ago. He also holds the second highest average hitter matchup strikeout percentage on the slate, per Batters-Box. That rating is considered elite, and in 23 prior elite ratings, he has recorded at least five strikeouts 82% of the time, six strikeouts 56%, and seven strikeouts 35%. Over his last 60 hitters faced, Pivetta owns a 33% strikeout rate.
Milwaukee enters today with nine hitters above the league strikeout rate and only one above the league ground ball rate. Low ground ball rates mean more opportunity at swings and misses, which is exactly what we want. In their last 60 plate appearances against right handed pitching, four Brewers hitters own strikeout percentages north of 23%.
With the Brewers fresh off clinching the division and the Padres still pushing for the NL West, I believe this is an excellent opportunity for San Diego to get a win against one of the league's best teams.
The Brewers may have already locked up the division, but San Diego still has everything to play for. This is the exact type of situation I want to target, and Nick Pivetta fits perfectly into that equation. With his strikeout profile, elite matchup metrics, and the added edge of facing a hungover lineup, the 4.5 prop looks like a strong position. You can either take the safe route with the juice or get aggressive by alt-lining to 5.5 for plus money. Either way, I expect Pivetta to take full advantage of the spot and set the tone early for the Padres.
Best Bet: Nick Pivetta Over 4.5 Strikeouts (-160) odds via BetOnline
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Former D1 (club) baseball player, Colby has been betting since his college days at DePaul, where he had to endure the worst collegiate basketball the Big East has ever seen. He is an advanced analytics nerd and has never seen an underdog he has not liked. Hot. Corn. Bull. It does not matter the dog he loves them all.
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