Tampa Bay Buccaneers vs Indianapolis Colts Betting Preview: Can the Surging Colts Take Down Another Title Contender?

Matt Wiesenfeld

After a slow start, the Colts have turned things around to be a factor in the AFC playoff picture. Last week, they produced one of the most impressive results of the NFL season as they crushed the Bills on the road. After taking down one Super Bowl contender, the Colts have the task of trying to take down another one this week as they take on Tom Brady and the Bucs.

The Bucs have been a different team on the road this season. The champs are a perfect 5-0 at home this season, but they are just 2-3 away from Raymond James Stadium. This should be a real test based on

This game is a matchup of two of the highest-scoring teams in the NFL. The Bucs are first in that category, while the Colts are fifth. Can Indy keep up with Brady and the Bucs at home?

Tampa Bay Buccaneers (7-3) vs Indianapolis Colts (6-5), FOX, 1:00 p.m. ET

Tampa Bay Buccaneers vs Indianapolis Colts NFL Betting Odds


  • Tampa Bay Buccaneers -3.5 (-104)
  • Indianapolis Colts +3.5 (-118)


  • OVER 53 (-114)
  • UNDER 53 (-106)


  • Tampa Bay Buccaneers -164
  • Indianapolis Colts +138

Tampa Bay Buccaneers vs. Indianapolis Colts odds are via FanDuel Sportsbook as of Sunday, November 28, 2021 at 4:00 a.m. ET. Want to see NFL betting odds from several top online sportsbooks for every NFL matchup each week? Check out our NFL odds.

Tampa Bay Buccaneers vs Indianapolis Colts NFL Betting Picks

Check out our Tampa Bay Buccaneers-Indianapolis Colts NFL betting picks, betting stats, and other Bucs vs Colts matchup info here: Tampa Bay Buccaneers vs Indianapolis Colts Matchup: NFL Betting Picks, Odds, Stats and More

Betting News aggregates our NFL betting picks from trusted sports betting industry sources. Along with NFL picks for every NFL matchup, we also offer MLB picks, NBA picks, and NHL picks.

Tampa Bay Buccaneers vs Indianapolis Colts Betting Preview

All three of the Bucs losses have been on the road this season. Nevertheless, they are first in passing offense and first in scoring, making them a dangerous out wherever you play them.

It definitely helps Tampa that the weather conditions will be favorable in Indianapolis too. The Bucs are first in the NFL against the run, and that is just as likely to determine the outcome in this game because the Colts definitely want to run the ball. The Bucs need to be able to get the Colts off of the field to put the offense in position to do what they can do.

The Colts have won three straight games to get back to relevancy in the AFC. They are a solid team but have to be overvalued after shellacking the Bills. The offense has been very effective of late. They have a strong offensive line, and when you combine that with the running ability of Jonathan Taylor, you get one of the most productive rushing attacks in the NFL.

The reason to be concerned about the Colts in this matchup is their defense. That group is more middle-tier than good, and they will have to try and slow Brady and the NFL’s best aerial attack. They had success against Josh Allen last week, but Brady is a different animal.

Tampa Bay Buccaneers vs Indianapolis Colts Best Bet

Tampa Bay Buccaneers -3.5

This spread feels a little too generous to the Colts who have to be at peak value off of their win last week. When they have the ball, it will be strength vs strength when they try to run. I do not expect Tampa to completely shut them down, but they will limit the red-hot Taylor. A contest between Brady and Carson Wentz is not going to work out well for the Colts, especially with the weapons Brady has at his disposal. Indy just won’t be able to keep up.

NFL Betting Prop Watch: Tampa Bay to Win (-2.5) & Over 43.5 Points (+115)

This is an alternate line parlay with the total being brought down. I love the Bucs to cover the number in a win, but the total scared me a little, so this one caught my eye. I could see an easy win falling in something like the 28-20 range because the Colts like to run the ball and eat the clock. This combo gives us some protection against that. I would be shocked if we get a 17-13 final score.

Tampa Bay Buccaneers vs Indianapolis Colts Score Prediction

Tampa Bay Buccaneers 30, Indianapolis Colts 20

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