Tennessee vs. LSU Week 6 Betting: Back the Volunteers to Win SEC Clash Against Tigers

Devon Platana

Written by: Devon Platana

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Tennessee vs. LSU Week 6 Betting: Back the Volunteers to Win SEC Clash Against Tigers cover


The 2022 NCAA college football season has been flying by as we already arrive at Week 6 of the schedule. As usual, there are many exciting matchups to watch this week, including a massive SEC collision between the No. 8 Tennessee Volunteers and No. 25 LSU Tigers.

Tennessee enters the week after spending Week 5 off. The Volunteers were last seen a few weeks ago in their 38-33 win over No. 20 Florida, which saw their running back room combine for 227 yards and three touchdowns on 42 carries.

Meanwhile, LSU has now won four games in a row following its 21-17 victory over Auburn this past weekend. The Tigers offense may have been inconsistent, however, the defense stepped up to save the day, walking out with four takeaways on the night.

Here are BetOnline Sportsbook’s latest Tennessee vs LSU betting odds, as well as a prediction and best bet for the upcoming NCAAF tilt.

Tennessee vs LSU Week 6 Matchup Information and Betting Odds

Matchup Information

  • Matchup: No. 8 Tennessee Volunteers (4-0, 1-0 SEC) vs. No. 25 LSU Tigers (4-1, 2-0 SEC)
  • Venue & Location: Tiger Stadium (Baton Rouge, Louisiana)
  • Date: Saturday, Oct. 8, 2022
  • Game Time: 12 p.m. Eastern Time
  • Where to Watch Tennessee vs LSU: ESPN

Tennessee vs LSU Odds

Game odds are via BetOnline Sportsbook as of Monday, Oct. 3 at 8:27 a.m. ET. Odds from other top online sportsbooks may also be mentioned in this article.


  • Tennessee -4.5 (-105)
  • LSU +4.5 (-115)


  • Over 59.5 (-110)
  • Under 59.5 (-110)


  • Tennessee -192
  • LSU +158

Tennessee vs LSU State Betting Trends

  • Tennessee is 0-5 straight up in its last five games against LSU.
  • LSU is 5-0 straight up in its last five home games.
  • Tennessee is 2-5 against the spread (ATS) in its last seven games played in October.
  • LSU is 1-4 ATS in its last six Week 6 matchups.
  • The total has hit the over in each of Tennessee’s last five games against the SEC.
  • The total has hit the under in five of LSU’s last six games against the SEC.

Tennessee Volunteers vs LSU Tigers Prediction and Picks

Tennessee vs LSU Prediction: Tennessee 33, LSU 27

Tennessee vs LSU: Tennessee -4.5 (Best Value: -105 at BetOnline) & Over 59.5 Points (Best Value: -110 at BetOnline)

This week’s matchup marks the 34th meeting between Tennessee and LSU. When it comes to the 33 previous battles, the Volunteers have emerged as the victors 20 times.

Having said that, Tennessee hasn’t beaten LSU since September 2005. The Tigers have won all five games since that last meeting, outscoring the Vols 133-69 over that stretch. One of those games was even for the 2007 SEC Championship.

Nevertheless, the most recent tilt took place in 2017 and a lot has changed since then. Although LSU has gotten the better of its SEC rival in recent history, I’m siding with Tennessee to win on the road this Saturday.

I think that the Volunteers are the better team because they’ve already been tested this season. They’ve won two close games against top-25 schools (Pittsburgh and Florida) while scoring a combined 132 points in their other two games.

LSU does have a lot to be proud of so far this season, but the Tigers haven’t exactly faced any world-beaters lately. I’m just unsure if Brian Kelly’s squad can handle Tennessee and its 48.5 points per game — second-most in the entire nation.

Meanwhile, LSU averages 28.3 PPG (T-No. 61) and has relied on its defense to get the job done at times. The Volunteer just might have too much firepower for the Tigers to keep pace, plus there’s the fact that Tennessee has a top-25 scoring defense as well.

Tennessee quarterback Hendon Hooker is leading the fourth-best passing attack in the NCAAF. At the end of the day, LSU hasn’t faced a challenge like that yet and could be in trouble thanks to its average secondary.

I expect a close game between two rivals, but I do expect the Volunteers to get the victory here. They’re more proven and battle-tested than their opponents, which should help them get the win on the road.

Neither SEC team’s defense is amazing this year, so I feel confident enough to back the over on this prop as the rivals fight for footing in the conference. I also recommend taking Tennessee as the 4.5-point moneyline favorite thanks to its offense being that much better than LSU’s unit.

Devon Platana
Devon Platana

Devon is a Master of Journalism graduate who joined the sports betting world in 2020. His favorite leagues to cover are the NHL, NBA and NFL, and has a soft spot for fantasy football specifically. Outside of sports, he enjoys the finer things in life like pasta, live music and getting even more tattoos.

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