<p>The American Conference may have changed its name, but its competitiveness remains the same. And with three weeks of regular season games left, five teams have one conference loss and harbor hope of a chance to dance with the big boys in the College Football Playoff. That cluster of contenders will drop by at least one this weekend, as Saturday’s South Florida vs. Navy matchup will be an elimination game for one team (12:00 p.m. ET, ESPN2).</p>
<p>USF’s CFP chances took a hit with a 34-31 loss at Memphis on October 25, but with the Tigers (8-2, 4-2 American) now likely out of the running after last Friday’s home loss to Tulane (7-2, 4-1 American), the Bulls (7-2, 4-1 American) have one fewer obstacle to reaching the conference championship game.</p>
<p>Another obstacle will be removed if they can maneuver past the Midshipmen (7-2, 5-1 American). Navy enters this matchup off the back of consecutive losses, first at fellow conference title hopeful North Texas (8-1, 4-1 American) and then at Notre Dame.</p>
<p>In addition to the Bulls, Green Wave, Midshipmen, Mean Green, East Carolina (6-3, 4-1 American), whose lone conference loss is to Tulane, also remains in the hunt ahead of this weekend’s home matchup with Memphis, who will be hoping for two wins and some favorable twists and turns across the next three weeks.</p>
<p>One of those favorable twists would be a Navy win vs. South Florida, but the Bulls make the trek to terrapin territory favored by more than a touchdown.</p>
<p>Will it be another prolific and successful day for Byrum Brown and the Bulls? Read on for our South Florida vs. Navy prediction and picks, as well as the best betting odds from <a href="/best-online-sportsbooks/">top online sportsbooks</a> such as <a href="https://affiliates.bettingnews.com/register/betonline" target="_blank" rel="noopener">BetOnline</a>.</p>
<h2><a href="https://affiliates.bettingnews.com/register/betonline" target="_blank" rel="noopener">South Florida vs. Navy Odds</a></h2>
<div class="su-table su-table-responsive su-table-alternate">
<table class="table table-bordered">
<thead>
<tr>
<th>Team</th>
<th>Spread</th>
<th>Moneyline</th>
<th>Over/Under</th>
</tr>
</thead>
<tbody>
<tr>
<th scope="row">South Florida</th>
<td>-10.5 (-110)</td>
<td>-385</td>
<td>Over 64.5 (-110)</td>
</tr>
<tr>
<th scope="row">Navy</th>
<td>+10.5 (-110)</td>
<td>+306</td>
<td>Under 64.5 (-110)</td>
</tr>
</tbody>
</table>
</div>
<h2>South Florida vs. Navy Betting Trends</h2>
<ul>
<li>South Florida is 7-2 against the spread this season, including 4-1 ATS as a favorite and 2-2 ATS on the road.</li>
<li>The Bulls are 7-9 SU and 9-7 ATS on the road under Alex Golesh, including 2-3 SU and ATS as a road favorite.</li>
<li>The over is 6-3 in South Florida&#8217;s games this season, including 6-1 in their last seven.</li>
<li>The over is 11-5 in USF&#8217;s road games under Alex Golesh, including 3-1 this season.</li>
<li>Navy is 2-7 against the spread this season, including 0-2 ATS as an underdog and 1-4 ATS at home.</li>
<li>The over is 7-2 in the Midshipmen&#8217;s games this season, including 4-1 in their home games.</li>
</ul>
<h2>South Florida vs. Navy Prediction and Picks</h2>
<h3>Prediction: South Florida to win</h3>
<p>After their fourth-quarter capitulation at Memphis, USF had nearly two weeks to sit, stew, and size up the next opponent.</p>
<p>Unfortunately for UTSA, they were up next for the Bulls, who routed the Roadrunners 55-23 last Thursday.</p>
<p>Byrum Brown filled up the stat sheet once again, completing 14 of 15 passes for 239 yards and two touchdowns and rushing for 109 yards and another score on nine attempts.</p>
<p>More of the same looks likely for Saturday’s South Florida vs. Navy matchup.</p>
<p>Saturday’s 49-10 loss at Notre Dame marked the fifth straight game in which Navy has allowed 30+ points, and while they got away with it against Air Force, Temple, and Florida Atlantic, they did not at North Texas and Notre Dame.</p>
<p>In their 31-17 loss to the Mean Green, the Midshipmen allowed UNT running back Caleb Hawkins to rack up 194 rushing yards and four scores. And in South Bend, they were undone by a balanced attack, as the Fighting Irish put up 253 yards and four touchdowns through the air and 249 yards and four touchdowns on the ground.</p>
<p>It also didn’t help that Navy was without starting quarterback Blake Horvath, who missed the game due to an upper body injury he reportedly suffered against North Texas.</p>
<p>Horvath may return as soon as this week, but that does not alter the outlook here.</p>
<p>That is because Brown and the South Florida offense should once again flex their mighty muscles vs. Navy, whose defense has not been up to the task in recent weeks.</p>
<p>Also, while the offense has garnered much of the attention for USF, the Bulls are one of the American’s best against the run and rank first or second in the conference in numerous notable pass defense categories, including interceptions.</p>
<h3>South Florida vs. Navy Picks</h3>
<h4>1) <a href="https://affiliates.bettingnews.com/register/betonline" target="_blank" rel="noopener">South Florida/Navy Over 64.5 (-110 at BetOnline)</a></h4>
<p>Overs have been a frequent result for both teams this season, and while the over did not happen for a similar total in Navy’s loss to North Texas two weeks ago, an under in this matchup would be a bigger surprise.</p>
<h4>2) <a href="https://affiliates.bettingnews.com/register/bovada" target="_blank" rel="noopener">South Florida Team Total Over 37.5 Points (-120 at Bovada)</a></h4>
<p>I took this play for South Florida’s game at Memphis when it was a lower number at better odds (over 34.5 for +125 odds), and it ultimately fell short because a holding penalty in the waning moments took Nico Gramatica’s game-tying field goal attempt from 42 yards to 52 yards, which he missed.</p>
<p>That result does not put me off taking South Florida to pile on the points vs. Navy in their first road game since that one. The Midshipmen do not look like stopping anyone, especially a quarterback who is putting up rushing numbers that would fit in well in Annapolis.</p>
<h2 id="other-college-football-betting-information">Other College Football Betting Information</h2>
<h3>Other NCAA Football Content at Betting News</h3>
<p>College football is one of the most popular sports to bet on, and Betting News cover it extensively. In addition to predictions and expert picks for matchups such as South Florida vs. Navy, you can check out our aggregated <a href="/ncaaf/picks/">college football picks</a>, compare <a href="/ncaaf/odds/">NCAA football odds</a> from <a href="https://affiliates.bettingnews.com/register/betonline/" target="_blank" rel="noopener">BetOnline</a> and other <a href="/ncaaf/college-football-betting-sites/">college football betting sites</a>, and <a href="/sports-betting-guides/college-football-betting-guide/">learn how to bet on college football</a> through the content we have on the site.</p>
<p>Be sure to bookmark Betting News so you can keep up with the content we provide for the 2025 college football season.</p>
<h3>Follow Betting News on Social Media</h3>
<p>Also, we cover college football in great depth on our Twitch streams and our other social media channels. Follow us on Twitch, Twitter, TikTok, and YouTube for frequent NCAA football betting insight from our content team.</p>
<p>That includes our weekly college football show, &#8220;The Ole College Try,&#8221; which streams every Tuesday afternoon at 3:30 p.m. ET.</p>
<ul>
<li><a href="https://twitter.com/YourBettingNews">Betting News on “X”/Twitter</a></li>
<li><a href="https://www.twitch.tv/bettingnews">Betting News on Twitch</a></li>
<li><a href="https://www.tiktok.com/@yourbettingnews?lang=en">Betting News on TikTok</a></li>
<li><a href="https://www.youtube.com/@YourBettingNews">Betting News on YouTube</a></li>
</ul>


South Florida quarterback Byrum Brown - South Florida vs. Navy Prediction & Picks (11/15/2025)

South Florida vs. Navy Prediction & Picks (11/15): Whose American Title Hopes Will End in Annapolis?

Kennesaw State vs. Jacksonville State: Conference USA Championship | December 5, 2025

Dan Mullen led the Rebels to 10 wins in his first season as Head Coach - Boise State UNLV Picks

UNLV vs. Boise State Picks and Predictions: Mountain West Championship

Duke quarterback Darian Mensah - No. 19 Virginia vs. Duke Prediction & Best Bets (11/15/2025)

Duke vs. #17 Virginia: ACC Conference Championship | December 6, 2025

Jeremiah Smith and Ohio State are back in the Big Ten Championship this season - Indiana Ohio State Picks

#2 Indiana vs. #1 Ohio State Picks and Predictions: Big Ten Championship

Jon Sumrall was hired as the next head coach of the Florida Gators - Tulane North Texas Picks

South Florida vs. Navy Prediction & Picks (11/15): Whose American Title Hopes Will End in Annapolis?

Eddie Griffin

More NCAAF News

Kennesaw State vs. Jacksonville State: Conference USA Championship | December 5, 2025

UNLV vs. Boise State Picks and Predictions: Mountain West Championship

Duke vs. #17 Virginia: ACC Conference Championship | December 6, 2025

#2 Indiana vs. #1 Ohio State Picks and Predictions: Big Ten Championship

#24 North Texas vs. #20 Tulane Picks and Predictions: AAC Championship