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South Carolina Gamecocks vs Missouri Tigers Picks

Memorial Stadium

<p>Two teams who call Columbia home meet in this SEC contest on Saturday Night. The South Carolina Gamecocks need to bounce back and find a conference win, while the No. 23 ranked Missouri Tigers look to keep their momentum rolling. While Missouri had to replace plenty of offensive production, they look rock solid and Beau Pribula is playing as good as any quarterback in the SEC. He has seven touchdowns and just one pick, along with nearly 800 passing yards and a completion percentage north of 76. Not to mention his three rushing touchdowns and 76 yards on the ground. But can they cover double digits against South Carolina at home? Let&#8217;s get into our picks.</p>
<p><strong>Editor&#8217;s Note: </strong>Missouri&#8217;s starting left tackle is out for this matchup, which may cause Hardy&#8217;s yards to drop a bit. Go ahead and snag a better number than I did, I still have faith he gets the job done for us.</p>
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<p>Go to <a href="/author/nate/">Betting News to check out what else I&#8217;ve got on the slate</a> for Week 4, and view the latest odds at the <a href="/best-online-sportsbooks/">best online sportsbooks.</a></p>
<h2><a href="/ncaaf/matchup/2025-09-20-south_carolina_gamecocks-missouri_tigers-n-1/">South Carolina Gamecocks vs. #23 Missouri Tigers NCAA Football Insights</a></h2>
<div id="attachment_82226" style="width: 1150px" class="wp-caption alignnone"><img loading="lazy" decoding="async" aria-describedby="caption-attachment-82226" class="size-full wp-image-82226" src="https://wp.bettingnews.com/wp-content/uploads/2025/08/Nyck-harbor-south-carolina-football.jpeg" alt="Nyck Harbor and South Carolina take on Missouri on the road - South Carolina Missouri Picks" width="1140" height="760" srcset="https://wp.bettingnews.com/wp-content/uploads/2025/08/Nyck-harbor-south-carolina-football.jpeg 1140w, https://wp.bettingnews.com/wp-content/uploads/2025/08/Nyck-harbor-south-carolina-football-300x200.jpeg 300w, https://wp.bettingnews.com/wp-content/uploads/2025/08/Nyck-harbor-south-carolina-football-1024x683.jpeg 1024w" sizes="auto, (max-width: 1140px) 100vw, 1140px" /><p id="caption-attachment-82226" class="wp-caption-text">Nyck Harbor and South Carolina take on Missouri on the road</p></div>
<p>The Gamecocks are looking to bounce back following an SEC loss to the Vanderbilt Fighting Diego Pavia&#8217;s, who dominated them for a 31-7 victory. This was after South Carolina took down Virginia Tech and South Carolina State. But LaNorris Sellers was injured against the Commodores, causing Luke Doty to take over, and he couldn&#8217;t do much. However, based on every report I can find and the line movement, Sellers will suit up this contest.</p>
<p>On the other sideline, Missouri is red hot. They blew out Central Arkansas and Louisiana, winning both games by a combined 97 points, and took down the Kansas Jayhawks in the Border War, winning 42-31 against their rival. They&#8217;ll look to start out strong in their first conference contest of the season, and facing a beat up Sellers makes it slightly easier.</p>
<h3>Matchup Information &#8211; South Carolina vs. Missouri &#8211; September 20</h3>
<ul>
<li>Venue &amp; Location: Memorial Stadium (Columbia, MO)</li>
<li>Date: Saturday, September 20, 2025</li>
<li>Kick Off: 7:00 p.m. Eastern</li>
<li>Broadcast: ESPN</li>
</ul>
<h3>South Carolina vs. Missouri Betting Odds</h3>
<p><em><a href="/best-online-sportsbooks/betonline/">Odds are courtesy of BetOnline</a>, one of our favorite online sportsbooks, as of September 20, 2025 at 8:49 a.m. eastern. Sign up today with <a href="https://affiliates.bettingnews.com/register/betonline/" target="_blank" rel="noopener">Promo Code BNBOL55 for a 55% deposit bonus.</a></em></p>
<h4>Spread</h4>
<ul>
<li>South Carolina +9.5 (-105)</li>
<li>Missouri -9.5 (-115)</li>
</ul>
<h4>Moneyline</h4>
<ul>
<li>South Carolina +280</li>
<li>Missouri -350</li>
</ul>
<h4>Total</h4>
<ul>
<li>Over 48.5 (-110)</li>
<li>Under 48.5 (-110)</li>
</ul>
<p>This line opened at +13.5, and I should&#8217;ve jumped on the Gamecocks right there. However, I didn&#8217;t want to get burned by bad news. It looks as if Sellers is going to play, and according to Pete Thamel earlier on Thursday, there is &#8220;optimism&#8221; surrounding Seller&#8217;s status for Saturday&#8217;s game. He has been participating in practice, Shane Beamer has not quite given the green light, but with a four point shift towards the Gamecocks, that is enough of an indicator that he takes the field for me.</p>
<p>Regardless, Missouri&#8217;s success has been undeniable, and ultimately I see them winning this game. Do they cover? Maybe, maybe not. I lean with South Carolina plus the points, but have missed the best number, so instead I&#8217;ll follow the game script in my head and bet on a player prop.</p>
<h2><a href="/ncaaf/matchup/2025-09-20-south_carolina_gamecocks-missouri_tigers-n-1/">South Carolina vs. #23 Missouri NCAA Football Picks and Predictions</a></h2>
<div id="attachment_84182" style="width: 730px" class="wp-caption alignnone"><img loading="lazy" decoding="async" aria-describedby="caption-attachment-84182" class="size-full wp-image-84182" src="https://wp.bettingnews.com/wp-content/uploads/2025/09/Ahmad-hardy-missouri-football-picks.jpg" alt="Hardy has ran for 100 yards in five straight games dating back to last season - South Carolina Missouri Picks" width="720" height="405" srcset="https://wp.bettingnews.com/wp-content/uploads/2025/09/Ahmad-hardy-missouri-football-picks.jpg 720w, https://wp.bettingnews.com/wp-content/uploads/2025/09/Ahmad-hardy-missouri-football-picks-300x169.jpg 300w" sizes="auto, (max-width: 720px) 100vw, 720px" /><p id="caption-attachment-84182" class="wp-caption-text">Hardy has ran for 100 yards in five straight games dating back to last season</p></div>
<h3>South Carolina vs. Missouri Prediction: Missouri Wins, South Carolina Covers, Over 48.5</h3>
<h3><a href="https://affiliates.bettingnews.com/register/betonline" target="_blank" rel="noopener">Best Bet: Ahmad Hardy Over 89.5 Rushing Yards (-118) BetOnline</a></h3>
<p>This guy might sneakily be the best running back in the country, and he&#8217;s a workhorse. Expect tons of carries from Hardy on Saturday. Missouri will feed him the ball, trying to chew up clock and keep Sellers and the Gamecock offense on the sidelines.</p>
<p>South Carolina&#8217;s rushing defense is pretty good, but last week they gave up almost four yards per carry, as Vandy ran for 146 yards as a team. This includes four different rushers going for a double digit carry, and one of their backs broke off a 44 yard rush as well. Missouri&#8217;s offensive line should abuse the Gamecock&#8217;s front seven, clearing plenty of gaps for Hardy to break free.</p>
<p>For starters, Hardy has cleared triple digit rushing yards in all three contests, doing so in as little as 10 attempts. This includes rushes of 44, 32 and 71 yards individually. He&#8217;s averaging 8.1 yards per carry, has five rushing touchdowns on the year, and has 22+ touches in each of his last two games. While the South Carolina defense will be the toughest he has faced, I expect a minimum of 20 carries from the kid, which should give us tons of chances to go over this number. Last year, he cleared triple digits in 8/12 games, and now has done it in 11/15 in his short collegiate career.</p>
<p>This is a game where I see the Tigers leading early, pounding the ground to run the clock and put together long drives, leaving Sellers holding his jock on the sidelines. Give me Hardy for 25 touches and another 100 yards on the ground.</p>
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