Week 6 Saturday Best Bets: NCAA Football Expert Picks & Predictions (10/10)
Written by: Nate Hornung
Published: Fri Oct 09, 2026, 5:00 pm ET
Read Time: 5 minutes
ncaaf
Spread
Total
Moneyline
+2.5
-105
55
-110o
+117
Spread
Total
Moneyline
-2.5
-110
55
-110u
-135
We are somehow already in the middle of Week 6 of the College Football season. So far, things have been going our way this year, but there's still a long ways to go. Keep reading to see what our NCAA Football experts will be betting on this Saturday, all of their picks are below.
Check out the best odds on the market and tons of picks for the NCAA Football Season.
NCAA Football Saturday's Predictions – October 10
#1 Texas vs. Oklahoma NCAA Football Picks
Best Bet: Oklahoma +7 (-110) BetOnline
Be sure to check out my full piece on why I'm backing the Sooners in this spot, but let's talk this over. We have a touchdown spread with a total listed under 40. That sounds like a very defensive game to me, making it much easier for Oklahoma to cover this number. While the Sooners have been underperforming so far, this is one they will wake up for.
Oklahoma has lost the past two Red River Rivalry's, failing to score a touchdown in either contest. This weekend, I think they can slow down the Longhorns who are looking at five straight ranked matchups after this battle. Don't be afraid to sprinkle on the Sooners outright.
#21 UCLA vs. #13 Oregon NCAA Football Picks
Best Bet: Wayne Knight Over 11.5 Receiving Yards (-115) BetOnline
This is easily my favorite player prop of the weekend. Wayne Knight has cleared this line with ease in all three games this year where he's at least caught a pass. The man has eight receptions for 88 yards so far this year, going for 20+ in 3/4 games this year. He is also the third leading pass catcher on this Bruins team.
Nico Iamaleava should see more pressure than he is used to, which could certainly lead to some check downs to Knight. He is very good with the ball in his hands, and this would be an easy way for UCLA to get their all star the ball with some room to work with. I wouldn't hate laddering this guy up to 20 or even 30 if you feel inclined to do so.
#22 Houston vs. Kansas State NCAA Football Picks
Avery Johnson and the Wildcats are coming off a bye at home, favored over a ranked opponent
Best Bet: Kansas State ML (-137) BetOnline
This might be my favorite bet of the weekend. The Wildcats are at home, coming off a bye week as an unranked favorite facing a ranked opponent. They are favored for a reason. Coming off a Big 12 loss, Kansas State knows this is one of the two toughest games remaining on their schedule.
This team needs to set the tone and get a big win, over a Cougars team that was down by 17 to UCF last week at home. Perhaps they were looking ahead. I don't think it will help them. Cats by 90.
#2 Georgia vs. #6 Alabama NCAA Football Picks
Best Bet: Georgia +2 (-110) and Under 51.5 (-110) BetOnline
PJ Glasser, an Alabama fan, broke this game down for us at Betting News. Check out why he's fading his team this weekend at home against Kirby Smart and the Bulldogs. I agree with his angles.
#19 USC vs. Penn State NCAA Football Picks
Rocco Becht and Penn State are not 0-2 in Big Ten play to start the season
Best Bet: Penn State ML (-118) BetOnline
I am already on the Nittany Lions ML in spirit, as I need a win to keep me on pace with my USC win total ticket. However I'll double down. It's a night game in Happy Valley, this is their annual Whiteout, and I love this spot. Penn State looked lifeless at Northwestern last Friday Night, making it two straight losses after three consecutive wins.
I trust Matt Campbell to turn things around with an extra day of rest, and I do not trust any of Lincoln Riley's teams headed more than one time zone east. Give me the hosts.
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Nate has been a recreational sports bettor for about 5 years. In that time, he has grown to love the pursuit of winners and sticking it to The Man. Nate loves data and uses his understanding of numbers to help him be a more profitable sports gambler, however he will be the first to tell you this game is about more than just stats.
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