Week 4 Saturday Best Bets: NCAA Football Expert Picks & Predictions (9/26)

Nate Hornung

Written by: Nate Hornung

Last Update: Sat Sep 26, 2026, 9:13 am ET

Read Time: 7 minutes

AJ Wilson has 12 catches for 133 yards this season, along with a touchdown NCAA Football Expert Picks

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Colorado State Rams logo
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UTSA Roadrunners logo

Colorado State Rams

45

UTSA Roadrunners

59
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Week 4 is here already in College Football and Saturday is once again packed with action for at least 12 viewing hours. Let's get into what our analysts think is worth wagering on this weekend as we dive into their expert NCAA Football picks.

Check out the best odds on the market and tons of picks for the NCAA Football Season.

NCAA Football Saturday's Predictions – September 26

#1 Texas vs. #14 Tennessee NCAA Football Picks

Best Bet: Hollywood Smothers Over 55.5 Rushing Yards (-114) BetOnline

Feel free to check out my full preview of this game here, but overall, I'm believing the books. If Texas is winning a close game in Knoxville, they will hand the ball off plenty to take pressure off of Arch Manning behind enemy lines. Hollywood Smothers split carries with Raleek Brown against Texas State and UTSA. But against Ohio State, in a big time, close game, Smothers out carried him 21-10. Hollywood is the top dawg.

Tennessee allowed Furman's top back to go for 113 yards, and three different players had 17, 24, and 34 yard rushes in that game. Against Georgia Tech, Justice Haynes had 81 yards and their backup ran for over 6.5 per carry. Smothers came up two yards short of clearing this line last week, but only had 10 touches. Give him at least 15 and he should take us to the cash counter.

I'm also not the only BN writer who approves of this play, Brandon Pham endorses it as well, and gives you some other Week 4 Player Props.

Colorado State vs. UTSA NCAA Football Picks

Owen McCown and the Roadrunners are coming off a loss to the top ranked Longhorns. This game at home should be a breeze. NCAA Football Expert Picks

Owen McCown and the Roadrunners are coming off a loss to the top ranked Longhorns. This game at home should be a breeze.

Best Bet: UTSA -13.5 (-125) BetOnline

I should've pulled the trigger on this one earlier than Friday Night, but I'll pay the buck 25 for the Roadrunners to win by two touchdowns. They are without a doubt the more battle tested team, winning a close game against Texas State (who will be better than the Rams in the Pac-12), and covering the spread against Texas in Austin (albeit, 30.5 points). I have a ticket for UTSA to win the American, so obviously I am high on this team.

But I'm very low on Colorado State. While they are off to a 2-1 start, wins over Wyoming and Southern Utah are unimpressive, and they had to score 16 garbage points in the fourth quarter against BYU to make it look like a competitive game.

At home, I see the Roadrunners dominating this team and putting them in their place.

#4 Ole Miss vs. #21 Florida NCAA Football Picks

Best Bet: Trinidad Chambliss Over 289.5 Passing Yards (-116) BetOnline

I give more of an opinion on the side in this matchup in my full breakdown, but as for this prop, I could ladder it up. Trinidad Chambliss has thrown for 300+ yards in 10/16 games as the Ole Miss starter, including twice this year, once on just 21 completions (336 total passing yards). He's had a 30+ yard completion in 13/17 games at the Division 1 level, and he's throwing the ball about 35 times per game this year.

If Florida controls the game like the odds suggest, Chambliss is going to be slinging the pill trying to catch up. The Gators allowed 271 passing yards from Byrum Brown on 35 attempts last weekend, and the Ole Miss quarterback is clearly the better pocket passer. I don't hate taking this up to 300+ for plus money, or even 315-325 if you are feeling frisky.

Nebraska vs. Michigan State NCAA Football Picks

Anthony Colandrea is used to using his legs to extend drives - NCAA Football Expert Picks

Anthony Colandrea is used to using his legs to extend drives

Best Bet: Anthony Colandrea Over 20.5 Rushing Yards (-112) BetOnline

Back the Nebraska QB to use his legs this weekend in East Lansing. He's only taken three sacks all year, and although I expect more pressure from the Spartans, the Husker's O-Line can protect him, or he'll escape with his feet. Colandrea is an explosive runner, as he has at least a 10 yard rush in 34/36 college games, and a 20+ yard rush in 15/36.

The former Virginia and UNLV quarterback has cleared this line in 2/3 games this season, finishing with 19 last week on just four carries. Again, in a hostile environment, he will be forced to run away from trouble, but he'll do it enough to cash our ticket.

#20 Oregon vs. #12 USC NCAA Football Picks

Best Bet: Oregon -3 (-110) BetOnline

Read all about why our guy PJ Glasser thinks the Ducks are quacking their way out of LA with a win over the Trojans.

#23 Texas A&M vs. #10 LSU NCAA Football Picks

Sam Leavitt has ran for nearly 200 yards already this year. Will he lead the Tigers to a win at home? NCAA Football Expert Picks

Sam Leavitt has ran for nearly 200 yards already this year. Will he lead the Tigers to a win at home?

Best Bet: LSU -8 (-110) BetOnline

Is this not the most obvious bounce back spot of all time? Sure, Texas A&M is also coming off an embarrassing loss at Kyle Field to Kentucky. But going into Death Valley at night, against the Lane Kiffin-led Tigers who were just upset in Oxford to start SEC play.. I'm sorry, Aggies fans, I don't like your chances.

The conspiracies are already going around that Texas A&M is only ranked to give LSU another "ranked win" at the end of the season, and to be honest, I think there is some truth to that. The Aggies are not as good offensively as they were last season. I am already on LSU in this game with my Texas A&M win total under ticket, but I'm confident enough in them to lay the points as well.

Both Kentucky running backs ran for nearly five yards per carry (4.8 and 9.7). Dillon Jones has gone for 100 yards in both of LSU's marquee games where he saw 20 touches, scoring in each of those as well. He should continue that against the Aggies. Sam Leavitt is also shifty, so I will be taking his 40+ rushing yards for (-119). Overall, LSU should prove last week's loss was nothing to be afraid of, while the Aggies might be spiraling after dropping two straight.

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Nate Hornung
Nate Hornung

Nate has been a recreational sports bettor for about 5 years. In that time, he has grown to love the pursuit of winners and sticking it to The Man. Nate loves data and uses his understanding of numbers to help him be a more profitable sports gambler, however he will be the first to tell you this game is about more than just stats.

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