San Francisco 49ers

2021 Record: 0-0

After reaching Super Bowl LIV, the San Francisco 49ers took a big step back in 2020, finishing last in the NFC West with a 6-10 record. Injuries were the biggest reason for their downturn in fortunes, with starting quarterback Jimmy Garoppolo being limited to only six games due to ankle injuries.

NFL futures odds expect a big rebound from the 49ers in 2021, who drafted North Dakota State star Trey Lance to compete with Garoppolo for the nod under center. As the regular season approaches, only last season’s NFC Championship Game combatants, the Tampa Bay Buccaneers and Green Bay Packers, are ahead of the 49ers as NFC favorites. And in a stacked NFC West, the 49ers edge out the Los Angeles Rams and Seattle Seahawks as division favorites.

Is that label deserved? We will see. Last season was their third losing season in four seasons under coach Kyle Shanahan, and it is rare to see such short odds for a team that could very start a rookie quarterback by choice or by force. But oddsmakers see success in San Francisco regardless of who starts under center, focusing on the team’s overall talent level, the upward trajectory the 49ers were on prior to the 2020 season, and a stout defense that still managed to be one of the NFL’s better defenses in a tough situation last season.

Will the 49ers stay healthy enough to live up to lofty expectations and contend for a sixth Super Bowl title?

San Francisco 49ers 2021 Schedule

Times are subject to change. Game odds are via FanDuel Sportsbook and are updated as of Tuesday, August 10, 2021.

Week 1

Date, Matchup, and TV Broadcast Information

Sunday, September 12, 2021: at Detroit Lions, 1:00 pm ET, FOX

San Francisco 49ers vs Detroit Lions Betting Odds

  • Spread: San Francisco 49ers -7.5 (-110), Detroit Lions +7.5 (-110)
  • Total: OVER 45.5 (-110), UNDER 45.5 (-110)
  • Moneyline: San Francisco 49ers -370, Detroit Lions +295

Week 2

Sunday, September 19, 2021: at Philadelphia Eagles, 1:00 pm ET, FOX

Week 3

Sunday, September 26, 2021: vs Green Bay Packers, 8:20 pm ET, NBC

Week 4

Sunday, October 3, 2021: vs Seattle Seahawks, 4:05 pm ET, FOX

Week 5

Sunday, October 10, 2021: at Arizona Cardinals, 4:25 pm ET, FOX

Week 6

BYE WEEK

Week 7

Sunday, October 24, 2021: vs Indianapolis Colts, 8:20 pm ET, NBC

Week 8

Sunday, October 31, 2021: at Chicago Bears, 1:00 pm ET, FOX

Week 9

Sunday, November 7, 2021: vs Arizona Cardinals, 4:25 pm ET, FOX

Week 10

Monday, November 15, 2021: vs Los Angeles Rams, 8:15 pm ET, ESPN

Week 11

Sunday, November 21, 2021: at Jacksonville Jaguars, 1:00 pm ET, FOX

Week 12

Sunday, November 28, 2021: vs Minnesota Vikings, 4:25 pm ET, FOX

Week 13

Sunday, December 5, 2021: at Seattle Seahawks, 8:20 pm ET, NBC

Week 14

Sunday, December 12, 2021: at Cincinnati Bengals, 1:00 pm ET, CBS

Week 15

Sunday, December 19, 2021: vs Atlanta Falcons, 4:05 pm ET, CBS

Week 16

Thursday, December 23, 2021: at Tennessee Titans, 8:20 pm ET, NFL Network

Week 17

Sunday, January 2, 2022: vs Houston Texans, 4:05 pm ET, CBS

Week 18

Sunday, January 9, 2022: at Los Angeles Rams, 4:25 pm ET, FOX

San Francisco 49ers 2021 Betting Information

  • SU: 0-0-0 (0-0-0 home, 0-0-0 away)
  • ATS: 0-0-0 (0-0-0 home, 0-0-0 away)
  • O/U: 0-0-0 (0-0-0 home, 0-0-0 away)

San Francisco 49ers 2021 Statistical Summary

Scoring

  • Scoring Offense: 0.0
  • Scoring Defense: 0.0

Total Yards Per Game

  • Offense: 0.0
  • Defense: 0.0

Passing Yards Per Game

  • Offense: 0.0
  • Defense: 0.0

Rushing Yards Per Game

  • Offense: 0.0
  • Defense: 0.0

San Francisco 49ers 2021 Season NFL Futures Odds

Odds to Win Super Bowl LVI

  • August 10: +1400

Odds to Win the NFC Championship

  • August 10: +650

Odds to Win the NFC West Title

  • August 10: +190

Odds to Make the NFL Playoffs

  • August 10: YES -205, NO +164

San Francisco 49ers 2021 Season Win Total

  • August 10: OVER 10.5 (+100), UNDER 10.5 (-120)

San Francisco 49ers odds are via FanDuel Sportsbook and are updated as of Tuesday, August 10, 2021.

Eddie Griffin
Eddie Griffin

Eddie Griffin has been writing about and Betting on sports for over a decade. For more of his thoughts on sports and sports betting, you can follow him on Twitter.

Eddie Griffin has been writing about and Betting on sports for over a decade. For more of his thoughts on sports and sports betting, you can follow him on Twitter.