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Los Angeles Rams vs San Francisco 49ers Picks

Levi's Stadium

<p>The <a href="/nfl/">NFL Week 15 schedule</a> begins with an NFC West clash on Thursday Night Football between the LA Rams (7-6) and San Francisco 49ers (6-7). This game-day preview features everything you need to get in on the TNF betting action, including the latest Rams vs. 49ers odds and picks.</p>
<p>With the NFC West being as close as it is, a victory is crucial for both sides tonight. Will LA continue its latest successful run? Or does San Francisco finally have what it takes to get back to the .500 mark?</p>
<p>Let&#8217;s answer those questions by diving into tonight&#8217;s Rams vs 49ers TNF predictions and best bets.</p>
<h4>NFL 2024 Game Record: 10-5-0 (66.7%)</h4>
<h4>NFL 2024 Best Bet + Prop Bet Record: 12-16-0 (42.9%)</h4>
<h4 style="text-align: center;"><a href="/best-online-sportsbooks/">Check out the best sportsbooks in the United States!</a></h4>
<h2>Rams vs 49ers NFL Week 15 Betting (12/12)</h2>
<p><img loading="lazy" decoding="async" class="size-full wp-image-55909 aligncenter" src="https://wp.bettingnews.com/wp-content/uploads/2024/09/brock-purdy-49ers-nfl.jpg" alt="NFL Week 15: Rams vs 49ers TNF Predictions, Odds &amp; Best Bets (12/15)" width="1024" height="576" srcset="https://wp.bettingnews.com/wp-content/uploads/2024/09/brock-purdy-49ers-nfl.jpg 1024w, https://wp.bettingnews.com/wp-content/uploads/2024/09/brock-purdy-49ers-nfl-300x169.jpg 300w" sizes="auto, (max-width: 1024px) 100vw, 1024px" /></p>
<h3>Rams vs 49ers Thursday Night Football Information</h3>
<ul>
<li><strong>Matchup:</strong> Los Angeles Rams (7-6, 3-3 Away) vs. San Francisco 49ers (6-7, 4-3 Home)</li>
<li><strong>Venue &amp; Location: </strong>Levi&#8217;s Stadium (Santa Clara, CA)</li>
<li><strong>Date:</strong> Thursday, Dec. 12, 2024</li>
<li><strong>Game Time:</strong> 8:15 p.m. ET</li>
<li><strong><a href="https://www.espn.com/nfl/schedule" target="_blank" rel="noopener">How to Watch Rams vs. 49ers</a>:</strong> Prime Video</li>
</ul>
<h3>LAR vs SF NFL Week 15 Odds</h3>
<p><strong><em><a href="https://affiliates.bettingnews.com/register/betonline/" target="_blank" rel="noopener sponsored">All Rams vs. 49ers NFL odds are courtesy of BetOnline</a> as of Thursday, Dec. 12 at 10:50 a.m. ET. Odds from other sportsbooks may also be mentioned in this article.</em></strong></p>
<h4 id="lkdn"><strong>Rams vs 49ers </strong>Spread</h4>
<ul>
<li>LA Rams +2.5 (+100)</li>
<li>San Francisco 49ers -2.5 (-120)</li>
</ul>
<h4 id="lkdn">49ers vs Rams Over/Under</h4>
<ul>
<li>Over 48.5 Points (-110)</li>
<li>Under 48.5 Points (-110)</li>
</ul>
<h4 id="lkdn"><strong>Rams vs 49ers</strong> Moneyline</h4>
<ul>
<li>LA Rams (+128)</li>
<li>San Francisco 49ers (-148)</li>
</ul>
<h4 style="text-align: center;">You might also like: <a href="/articles/nfl/nfl-week-15-bills-lions-predictions-odds-best-bets-2024-12-15/">Bills vs. Lions NFL Week 15 Predictions &amp; Odds</a></h4>
<hr />
<h2 id="epf1r">How to Bet on 2024 NFL Season</h2>
<p>Hungry to pounce on other NFL Week 15 markets? Are you looking to get in on even more Rams vs. 49ers TNF betting odds? <em>Betting News</em> has your football needs covered from now through February!</p>
<p>We have many betting resources, ranging from daily NFL odds and betting predictions to expert picks. You can find them below to help you get started:</p>
<ul>
<li><a href="/nfl/">NFL Betting Articles</a></li>
<li><a href="/nfl/odds/">NFL Betting Odds</a></li>
<li><a href="/nfl/picks/">NFL Picks Page</a></li>
</ul>
<hr />
<h2>Rams vs 49ers NFL Week 15 Betting Trends</h2>
<ul>
<li>The Rams are 6-2 straight up in their last eight games.</li>
<li>San Francisco is 9-3 straight up in its last 12 games vs. the Rams.</li>
<li>The Rams are 7-1 ATS in their last eight games played in December.</li>
<li>San Francisco is 4-10 ATS in its last 14 home games.</li>
<li>The total hit the Over in four of the Rams&#8217; last five games vs. San Francisco.</li>
<li>The total hit the Over in six of San Francisco&#8217;s last eight Week 15 matchups.</li>
</ul>
<h4 style="text-align: center;"><a href="/canada-sportsbooks/">Check out some of the best sportsbooks in Canada!</a></h4>
<h2>Rams vs 49ers NFL Week 15 Predictions &amp; Picks (12/12)</h2>
<p>After an uninspiring 1-4 SU start to the 2024 season, the Rams have quickly become one of the NFL&#8217;s hottest teams.</p>
<p>Sean McVay&#8217;s squad improved to 6-2 SU in its last eight outings with last week&#8217;s impressive 44-42 win over the Buffalo Bills. It was a dominant aerial performance from the Rams as Puka Nacua hauled in a whopping 12 balls for 162 receiving yards and a touchdown while Cooper Kupp posted an impressive 5-92-1 stat line. Los Angeles is now back on the road, where it&#8217;s 3-0 SU with a plus-6.3 average scoring margin in its last three away contests.</p>
<p>Meanwhile, the 49ers are heading into tonight&#8217;s TNF clash after snapping their skid with a 38-13 victory against the Chicago Bears in Week 14. Even though it was an impressive performance, it&#8217;s worth noting that the outing also marked the Bears&#8217; seventh straight loss, leaving time to tell whether the 49ers won because they&#8217;re actually good or if it had more to do with their opponent&#8217;s issues.</p>
<p style="text-align: center;"><img loading="lazy" decoding="async" class="size-large wp-image-55741 aligncenter" src="https://wp.bettingnews.com/wp-content/uploads/2024/09/HSKJK6CKD5EYXPRIDA23BNRJ7I-e1728570280211-1024x480.jpg" alt="NFL Week 15: Rams vs 49ers TNF Predictions, Odds &amp; Best Bets (12/15)" width="1024" height="480" srcset="https://wp.bettingnews.com/wp-content/uploads/2024/09/HSKJK6CKD5EYXPRIDA23BNRJ7I-e1728570280211-1024x480.jpg 1024w, https://wp.bettingnews.com/wp-content/uploads/2024/09/HSKJK6CKD5EYXPRIDA23BNRJ7I-e1728570280211-300x140.jpg 300w, https://wp.bettingnews.com/wp-content/uploads/2024/09/HSKJK6CKD5EYXPRIDA23BNRJ7I-e1728570280211-768x360.jpg 768w, https://wp.bettingnews.com/wp-content/uploads/2024/09/HSKJK6CKD5EYXPRIDA23BNRJ7I-e1728570280211-1536x719.jpg 1536w, https://wp.bettingnews.com/wp-content/uploads/2024/09/HSKJK6CKD5EYXPRIDA23BNRJ7I-e1728570280211-2048x959.jpg 2048w" sizes="auto, (max-width: 1024px) 100vw, 1024px" /><em>Do the 49ers have what it takes to win consecutive games for the first time in over a month? </em></p>
<p>When it comes to these franchises&#8217; history, the recent results have favored the 49ers, who are 9-3 SU in their last 12 meetings with the Rams.</p>
<p>Having said that, it was the Rams who got the last laugh when these teams collided in Week 3, earning a 27-24 win over the 49ers thanks to a last-second field goal from Joshua Karty. Including that game, San Francisco is only 1-3 SU against NFC West teams this season whereas Los Angeles is 2-1 SU in that regard.</p>
<p>I could see the Rams sweeping the series with an upset tonight. Even though the odds are on the 49ers&#8217; side, they&#8217;re only 1-4 ATS in their last five games this season as well as 4-10 ATS in their last 14 home games overall. Los Angeles might not be perfect, but it&#8217;s at least 5-2 ATS in its last seven outings on top of covering the spread in all but one of their last eight TNF outings.</p>
<p>With that being said, back the <strong>Rams to win and cover as 2.5-point underdogs tonight</strong>.</p>
<h4 id="6mch7"><strong>Rams vs. 49ers NFL Week 15 TNF Prediction:</strong> LAR wins</h4>
<h4>Best Rams vs. 49ers<strong> </strong>Bet: LAR +2.5 (+100)</h4>
<h4 id="9ggl9" style="text-align: center;"><a href="/nfl/">Don’t forget to check out our NFL picks page today!</a></h4>
<h2 id="56ah2">Best Rams vs 49ers NFL Week 15 Player Prop Bet</h2>
<p>There&#8217;s absolutely nothing wrong with going with a <strong>Puka Nacua anytime touchdown (<a href="https://affiliates.bettingnews.com/register/sportsbetting/" target="_blank" rel="noopener">+120 on SportsBetting</a>)</strong> for tonight&#8217;s best Rams vs. 49ers TNF player prop bet.</p>
<p><img loading="lazy" decoding="async" class="size-full wp-image-39344 aligncenter" src="https://wp.bettingnews.com/wp-content/uploads/2023/10/puka-nacua-los-angeles-rams_de79a7d4334c934630af82a52735a6f2_2000.jpeg" alt="NFL Week 15: Rams vs 49ers TNF Predictions, Odds &amp; Best Bets (12/15)" width="1024" height="576" srcset="https://wp.bettingnews.com/wp-content/uploads/2023/10/puka-nacua-los-angeles-rams_de79a7d4334c934630af82a52735a6f2_2000.jpeg 1024w, https://wp.bettingnews.com/wp-content/uploads/2023/10/puka-nacua-los-angeles-rams_de79a7d4334c934630af82a52735a6f2_2000-300x169.jpeg 300w" sizes="auto, (max-width: 1024px) 100vw, 1024px" /></p>
<p>Nacua has been on a tear after <a href="https://www.nfl.com/news/rams-wr-puka-nacua-knee-active-vs-seahawks" target="_blank" rel="noopener">missing five games due to a knee injury</a>. After returning to action in Week 8, the ex-BYU playmaker has gone on to rack up 50 receptions, 673 receiving yards, and three touchdowns in his last seven outings. He&#8217;s seen at least eight targets in each of his last five games (11.6 per outing) and has found the end zone in three of his last four appearances.</p>
<p>Although the 49ers have defended the pass well this season, they&#8217;ve still allowed 11 TDs to opposing wideouts. That&#8217;s pretty good news for Nacua, who has a 19-188-1 stat line in two previous encounters with San Francisco.</p>
<p>As long as he remains quarterback Matt Stafford&#8217;s favorite target, Nacua is in a good spot to record TD No. 4 tonight.</p>
<h4 style="text-align: left;">Best Rams vs. 49ers TNF Player Prop: Puka Nacua Anytime Touchdown (+120)</h4>
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