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Pittsburgh Steelers vs Carolina Panthers Picks

Bank of America Stadium

<p>We have finally reached the final week of NFL Preseason action, meaning the real deal is right around the corner. It&#8217;s been a long several months without the pigskin, but not only do we get Week 0 in NCAA Football this Saturday, but we also have NFL Preseason matchups on Thursday, Friday and Saturday, keeping you entertained on the gridiron all weekend long. Tonight we dive in to the matchup on NFL Network, as Mike Tomlin and the Pittsburgh Steelers travel south to take on the Carolina Panthers. Let&#8217;s get into our favorite picks!</p>
<p>Check out the latest odds at the <a href="/best-online-sportsbooks/">best online sportsbooks.</a> Plus, take some time to check out our NFL Divisional Previews below.</p>
<ul>
<li><a href="/articles/nfl/afc-west-2025-divisional-preview-picks-predictions-will-chiefs-finally-crumble/">AFC West Divisional Picks</a></li>
<li><a href="/articles/nfl/nfc-west-2025-divisional-preview-picks-predictions/">NFC West Divisional Predictions</a></li>
<li><a href="/articles/nfl/afc-east-2025-divisional-preview-picks-predictions/">AFC East Divisional Preview</a></li>
<li><a href="/articles/nfl/nfc-east-2025-divisional-preview-picks-predictions/">NFC East Divisional Insights</a></li>
<li><a href="/articles/nfl/afc-north-2025-divisional-preview-picks-predictions/">AFC North Divisional Predictions</a></li>
<li><a href="/articles/nfl/nfc-north-2025-divisional-preview-picks-predictions/">NFC North Divisional Picks</a></li>
<li><a href="/articles/nfl/afc-south-2025-divisional-preview-picks-predictions/">AFC South Divisional Preview</a></li>
<li><a href="/articles/nfl/nfc-south-2025-divisional-preview-picks-predictions/">NFC South Divisional Insights</a></li>
</ul>
<h2><a href="/nfl/matchup/2025-08-21-pittsburgh_steelers-carolina_panthers-n-1/">Pittsburgh Steelers vs. Carolina Panthers NFL Picks</a></h2>
<div id="attachment_52972" style="width: 1450px" class="wp-caption alignnone"><img loading="lazy" decoding="async" aria-describedby="caption-attachment-52972" class="size-full wp-image-52972" src="https://wp.bettingnews.com/wp-content/uploads/2024/07/Mike-Tomlin.webp" alt="Mike Tomlin has indicated several starters will sit in tonight's NFL preseason finale - Steelers Panthers Picks" width="1440" height="810" srcset="https://wp.bettingnews.com/wp-content/uploads/2024/07/Mike-Tomlin.webp 1440w, https://wp.bettingnews.com/wp-content/uploads/2024/07/Mike-Tomlin-300x169.webp 300w, https://wp.bettingnews.com/wp-content/uploads/2024/07/Mike-Tomlin-1024x576.webp 1024w" sizes="auto, (max-width: 1440px) 100vw, 1440px" /><p id="caption-attachment-52972" class="wp-caption-text">Mike Tomlin has indicated several starters will sit in tonight&#8217;s NFL preseason finale</p></div>
<p>This is the final game for either team before the regular season begins. Will that change the personnel coaches use? Maybe their tactics regarding the entire game overall?</p>
<p>For the Panthers, they are digging deep into their depth chart. Neither Bryce Young or Andy Dalton will see the field in their preseason finale, leaving Jack Plummer and UFL MVP, Bryce Perkins to lead the offense. Carolina has been outscored 50-13 in their opening preseason matches, and clearly they aren&#8217;t too concerned if they are sitting their top two quarterbacks in this contest.</p>
<p>For Mike Tomlin&#8217;s Steelers, he has only ruled out Aaron Rodgers, DK Metcalf, Cam Heyward and TJ Watt. While those studs won&#8217;t take the field, he has mentioned we might see the starting Pittsburgh secondary for a few drives. Even if Mason Rudolph sits as well, Skylar Thompson is ready to lead the Steelers to victory.</p>
<p>Let&#8217;s check out the betting odds.</p>
<h3>Matchup Information &#8211; Steelers vs. Panthers</h3>
<ul>
<li>Venue &amp; Location: Bank of America Stadium (Charlotte, NC)</li>
<li>Date: Thursday, August 21, 2025</li>
<li>Kick Off: 7:00 p.m. Eastern</li>
<li>Broadcast: NFL Network</li>
</ul>
<h3>Steelers vs. Panthers Betting Odds &#8211; August 21</h3>
<p><em><a href="/best-online-sportsbooks/betonline/">Odds are courtesy of BetOnline</a>, one of our favorite online sportsbooks. Sign up today with <a href="https://affiliates.bettingnews.com/register/betonline/" target="_blank" rel="noopener">Promo Code FREE250 for a 50% deposit bonus up to $250</a> as well as 100 Free Spins at the online casino.</em></p>
<h4>Spread</h4>
<ul>
<li>Steelers -5.5 (-110)</li>
<li>Panthers +5.5 (-110)</li>
</ul>
<h4>Moneyline</h4>
<ul>
<li>Steelers -235</li>
<li>Panthers +195</li>
</ul>
<h4>Total</h4>
<ul>
<li>Over 35 (-110)</li>
<li>Under 35 (-110)</li>
</ul>
<div id="attachment_57891" style="width: 1510px" class="wp-caption alignnone"><img loading="lazy" decoding="async" aria-describedby="caption-attachment-57891" class="size-full wp-image-57891" src="https://wp.bettingnews.com/wp-content/uploads/2024/10/image-33.jpg" alt="Neither Andy Dalton or Bryce Young will see the field tonight for Carolina - Steelers Panthers Picks" width="1500" height="844" srcset="https://wp.bettingnews.com/wp-content/uploads/2024/10/image-33.jpg 1500w, https://wp.bettingnews.com/wp-content/uploads/2024/10/image-33-300x169.jpg 300w, https://wp.bettingnews.com/wp-content/uploads/2024/10/image-33-1024x576.jpg 1024w" sizes="auto, (max-width: 1500px) 100vw, 1500px" /><p id="caption-attachment-57891" class="wp-caption-text">Neither Andy Dalton or Bryce Young will see the field tonight for Carolina</p></div>
<p>Get ready for another NFL Preseason crapshoot of a game, cause that&#8217;s what it looks like we will get. The top four QBs (two from each team) will likely sit on the bench, giving some guys who won&#8217;t play a real snap this season a few practice reps.</p>
<p>Regardless, I have been targeting unders for the entire preseason, and I don&#8217;t see why I should stop now. The Panthers have scored just one touchdown in their opening two games, and I have very little faith in Plummer or Perkins to lead the offense to some scores, especially considering we might see the Steelers&#8217; starting secondary for a bit.</p>
<p>Moving the ball is going to be a problem for both sides in this matchup, and to me, that translates into a very easy under.</p>
<h2><a href="/nfl/matchup/2025-08-21-pittsburgh_steelers-carolina_panthers-n-1/">Pittsburgh Steelers vs. Carolina Panthers Picks and Predictions</a></h2>
<div id="attachment_81357" style="width: 1210px" class="wp-caption alignnone"><img loading="lazy" decoding="async" aria-describedby="caption-attachment-81357" class="size-full wp-image-81357" src="https://wp.bettingnews.com/wp-content/uploads/2025/08/Porter-1.jpg" alt="Joey Porter Jr. leads the Pittsburgh secondary - Steelers Panthers Picks" width="1200" height="824" srcset="https://wp.bettingnews.com/wp-content/uploads/2025/08/Porter-1.jpg 1200w, https://wp.bettingnews.com/wp-content/uploads/2025/08/Porter-1-300x206.jpg 300w, https://wp.bettingnews.com/wp-content/uploads/2025/08/Porter-1-1024x703.jpg 1024w" sizes="auto, (max-width: 1200px) 100vw, 1200px" /><p id="caption-attachment-81357" class="wp-caption-text">Joey Porter Jr. leads the Pittsburgh secondary</p></div>
<h3>Steelers vs. Panthers NFL Prediction: Steelers Win, Under 35</h3>
<h3><a href="https://affiliates.bettingnews.com/register/betonline/" target="_blank" rel="noopener">Best Bet: Under 35 (-110) BetOnline</a></h3>
<p>No Aaron Rodgers, and likely no Mason Rudolph. No Bryce Young and no Andy Dalton. Skyler Thompson and Jack Plummer are simply not capable of putting points on the board.</p>
<p>We also won&#8217;t see DK Metcalf, and likely no Tet McMillan as he nurses an injury in preparation for the season. Again, the point is, who out there is capable of scoring?</p>
<p>Carolina can&#8217;t move the ball. The Steelers weren&#8217;t able to do so against a decent defense last week, putting up just 14 against the Tampa Bay Buccaneers. And ultimately, both teams will rely on defense all season long to keep them competitive in games.</p>
<p>I think that begins tonight in Charlotte as we see a sloppy, boring final preseason matchup between the Panthers and Steelers.</p>
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<ul>
<li><a href="/articles/nfl/afc-west-2025-divisional-preview-picks-predictions-will-chiefs-finally-crumble/">AFC West Divisional Picks</a></li>
<li><a href="/articles/nfl/nfc-west-2025-divisional-preview-picks-predictions/">NFC West Divisional Predictions</a></li>
<li><a href="/articles/nfl/afc-east-2025-divisional-preview-picks-predictions/">AFC East Divisional Preview</a></li>
<li><a href="/articles/nfl/nfc-east-2025-divisional-preview-picks-predictions/">NFC East Divisional Insights</a></li>
<li><a href="/articles/nfl/afc-north-2025-divisional-preview-picks-predictions/">AFC North Divisional Predictions</a></li>
<li><a href="/articles/nfl/nfc-north-2025-divisional-preview-picks-predictions/">NFC North Divisional Picks</a></li>
<li><a href="/articles/nfl/afc-south-2025-divisional-preview-picks-predictions/">AFC South Divisional Preview</a></li>
<li><a href="/articles/nfl/nfc-south-2025-divisional-preview-picks-predictions/">NFC South Divisional Insights</a></li>
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