<p>The wait is over. It&#8217;s been several long months since we last saw some football on our screens, but tonight the NFL returns with the Hall of Fame Game, kicking off the preseason between the Los Angeles Chargers and the Detroit Lions in Canton, Ohio. Our expert&#8217;s have been itching to bet some football all offseason, so of course we dove in to this matchup and found our favorite picks for tonight.</p>
<p>Check out the latest odds at the <a href="/best-online-sportsbooks/">best online sportsbooks.</a> Plus, take some time to check out our NFL Divisional Previews below.</p>
<ul>
<li><a href="/articles/nfl/afc-west-2025-divisional-preview-picks-predictions-will-chiefs-finally-crumble/">AFC West Divisional Picks</a></li>
<li><a href="/articles/nfl/nfc-west-2025-divisional-preview-picks-predictions/">NFC West Divisional Predictions</a></li>
<li><a href="/articles/nfl/afc-east-2025-divisional-preview-picks-predictions/">AFC East Divisional Preview</a></li>
<li><a href="/articles/nfl/nfc-east-2025-divisional-preview-picks-predictions/">NFC East Divisional Insights</a></li>
<li><a href="/articles/nfl/afc-north-2025-divisional-preview-picks-predictions/">AFC North Divisional Predictions</a></li>
<li><a href="/articles/nfl/nfc-north-2025-divisional-preview-picks-predictions/">NFC North Divisional Picks</a></li>
</ul>
<p>Don&#8217;t worry, we&#8217;re saving the South for last, should be up next week!</p>
<p>Alright, time to get into tonight&#8217;s matchup.</p>
<h2><a href="/nfl/picks/">Los Angeles Chargers vs. Detroit Lions: Hall of Fame Game Picks</a></h2>
<div id="attachment_79232" style="width: 1450px" class="wp-caption alignnone"><img loading="lazy" decoding="async" aria-describedby="caption-attachment-79232" class="size-full wp-image-79232" src="https://wp.bettingnews.com/wp-content/uploads/2025/07/Campbell.jpg" alt="Dan Campbell leads the Lions into the 2025 Hall of Fame Game - Chargers Lions Picks" width="1440" height="960" srcset="https://wp.bettingnews.com/wp-content/uploads/2025/07/Campbell.jpg 1440w, https://wp.bettingnews.com/wp-content/uploads/2025/07/Campbell-300x200.jpg 300w, https://wp.bettingnews.com/wp-content/uploads/2025/07/Campbell-1024x683.jpg 1024w" sizes="auto, (max-width: 1440px) 100vw, 1440px" /><p id="caption-attachment-79232" class="wp-caption-text">Dan Campbell leads the Lions into the 2025 Hall of Fame Game</p></div>
<h3>Matchup Information</h3>
<ul>
<li>Venue &amp; Location: Tom Benson Hall of Fame Stadium (Canton, OH)</li>
<li>Date: Thursday, July 31, 2025</li>
<li>Kick Off: 8:00 p.m. Eastern</li>
<li>Broadcast: NBC/Peacock</li>
</ul>
<h3>Chargers vs. Lions Betting Odds &#8211; July 31</h3>
<p><em><a href="/best-online-sportsbooks/betonline/">Odds are courtesy of BetOnline</a>, one of our favorite online sportsbooks. Sign up today with <a href="https://affiliates.bettingnews.com/register/betonline/" target="_blank" rel="noopener">Promo Code FREE250 for a 50% deposit bonus up to $250</a> as well as 100 Free Spins at the online casino.</em></p>
<h4>Spread</h4>
<ul>
<li>Chargers +1.5 (-118)</li>
<li>Lions -1.5 (-102)</li>
</ul>
<h4>Moneyline</h4>
<ul>
<li>Chargers +101</li>
<li>Lions -121</li>
</ul>
<h4>Total</h4>
<ul>
<li>Over 34 (-110)</li>
<li>Under 34 (-110)</li>
</ul>
<p>Can I just say&#8230; it feels fantastic to be chit chatting about some football. Seeing a total for anything above four really gets me going (I&#8217;ve been betting a lot of soccer this offseason), and tonight&#8217;s game is just the teaser for what should be another phenomenal NFL season.</p>
<p>However tonight we are likely not going to see very many starters, as Los Angeles has already indicated QB Trey Lance will take over for the offense tonight. I would imagine we don&#8217;t see Jared Goff or any of the Lions&#8217; skill players as well. But let&#8217;s dive in deeper about who might be seeing the field, and how we can go about wagering on this Hall of Fame Game.</p>
<h2><a href="/nfl/picks/">Los Angeles Chargers vs. Detroit Lions Picks and Predictions</a></h2>
<div id="attachment_79235" style="width: 1210px" class="wp-caption alignnone"><img loading="lazy" decoding="async" aria-describedby="caption-attachment-79235" class="size-full wp-image-79235" src="https://wp.bettingnews.com/wp-content/uploads/2025/07/Lance-2.jpg" alt="Trey Lance starts for the Chargers tonight in the Hall of Fame Game - Chargers Lions Picks" width="1200" height="675" srcset="https://wp.bettingnews.com/wp-content/uploads/2025/07/Lance-2.jpg 1200w, https://wp.bettingnews.com/wp-content/uploads/2025/07/Lance-2-300x169.jpg 300w, https://wp.bettingnews.com/wp-content/uploads/2025/07/Lance-2-1024x576.jpg 1024w" sizes="auto, (max-width: 1200px) 100vw, 1200px" /><p id="caption-attachment-79235" class="wp-caption-text">Trey Lance starts for the Chargers tonight in the Hall of Fame Game</p></div>
<h3>Chargers vs. Lions NFL Prediction: Lions Win, Under 34</h3>
<h3><a href="https://affiliates.bettingnews.com/register/betonline/" target="_blank" rel="noopener">Best Bet: LAC/DET 1H Under 17.5 (-108) BetOnline</a></h3>
<p>I think we see points in this matchup, but I don&#8217;t think we see too many early. We obviously are not going to get the top offensive players, and likely won&#8217;t see the best of the best on defense either. However my theory is defense takes less rust to shake off, while you need some time to let an offense gel and build a rhythm.</p>
<p>In this game tonight, I&#8217;m not sure how much rhythm we will see from these two backup squads.</p>
<p>Trey Lance doesn&#8217;t move the needle for me, and Dan Campbell has said we won&#8217;t see very many starters. Hendon Hooker will lead the Lions, with Kyle Allen likely getting some reps as well. Despite the first team defenses probably not trotting out their either, I&#8217;ll side with a back up defense over a back up offense in the very first game of the season.</p>
<p>Both of these coaches are very defensive minded, and I bet it shows tonight, especially with both teams ranking in the top 10 in points allowed last season.</p>
<p>Give me less than three scores in the first half.</p>
<h2>Still Didn&#8217;t Get Your NFL Fix?</h2>
<p>Here at Betting News, we offer <a href="/picks/">Free Expert Picks</a> for every major sports league. We also host daily streams on our <a href="https://www.twitch.tv/bettingnews">Twitch Channel with our best bets</a>, as well as <a href="https://www.playback.tv/bettingnews">sweat out games on Playback! </a>Be sure to tune into everything we have going on at our <a href="https://www.youtube.com/@YourBettingNews">Youtube</a>, <a href="https://www.tiktok.com/@yourbettingnews">TikTok</a>, and <a href="https://twitter.com/YourBettingNews">X pages as well</a>.</p>
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<li><a href="/articles/nfl/afc-west-2025-divisional-preview-picks-predictions-will-chiefs-finally-crumble/">AFC West Divisional Picks</a></li>
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<li><a href="/articles/nfl/afc-north-2025-divisional-preview-picks-predictions/">AFC North Divisional Predictions</a></li>
<li><a href="/articles/nfl/nfc-north-2025-divisional-preview-picks-predictions/">NFC North Divisional Picks</a></li>
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