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Philadelphia Eagles vs Kansas City Chiefs Picks

GEHA Field at Arrowhead Stadium

Kansas City Chiefs vs Philadelphia Eagles: The highly anticipated Super Bowl rematch kicks off in Kansas City, where the Chiefs aim to avenge their 40-22 defeat to the Philadelphia Eagles in Super Bowl 59. Kansas City opened its 2025 season with a 27-21 divisional loss to the Los Angeles Chargers. Philadelphia also faced a division rival, but held on for a 24-20 win over the Cowboys. 
Will the Chiefs avoid their first 0-2 start since 2014, or will the defending champs get the best of Patrick Mahomes once again? Let’s dive into my predictions and picks for the Chiefs vs. Eagles.
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<h2><a href="/nfl/matchup/2025-09-14-philadelphia_eagles-kansas_city_chiefs-n-1/" target="_blank" rel="noopener">Kansas City Chiefs vs Philadelphia Eagles NFL Betting Insights</a></h2>
&nbsp;
<div id="attachment_64510" style="width: 525px" class="wp-caption aligncenter"><img loading="lazy" decoding="async" aria-describedby="caption-attachment-64510" class=" wp-image-64510" src="https://wp.bettingnews.com/wp-content/uploads/2024/02/patrick-mahomes-chiefs-afc-championship-game-vs-bills-300x169.jpg" alt="" width="515" height="290" srcset="https://wp.bettingnews.com/wp-content/uploads/2024/02/patrick-mahomes-chiefs-afc-championship-game-vs-bills-300x169.jpg 300w, https://wp.bettingnews.com/wp-content/uploads/2024/02/patrick-mahomes-chiefs-afc-championship-game-vs-bills.jpg 1024w" sizes="auto, (max-width: 515px) 100vw, 515px" />Can Patrick Mahomes help the Chiefs avoid their first 0-2 start since 2014?</div>
Betting Landscape: Oddsmakers opened Kansas City as a 1.5-point favorite, with the total ranging between 45.5 and 47.5. Now, most books have settled at 47 for the total, but the spread has flipped &#8211; Philadelphia is currently favored by 1.5. That move stems from Week 1 results, injury updates and betting splits.
It’s understandable to be a bit confused by that movement. After all, it is against Patrick Mahomes and Andy Reid, and the Chiefs should have extra motivation for revenge after the Super Bowl loss, right? 
But history says otherwise. There have been 11 instances of a Super Bowl rematch the following season, and the champion has gone 8-3 in those games. So maybe revenge isn’t the angle to bank on. Philadelphia was the more complete team last season, and early indications show that hasn’t changed.
Injury News: Kansas City’s biggest concern is rookie wideout Xavier Worthy, who dislocated his shoulder in Week 1 after colliding with Travis Kelce. He returned to practice Thursday in a limited role, but even if he suits up he may not be at full strength, which is a significant factor given his role in the Chiefs’ offense.
Philadelphia is monitoring tight end Dallas Goedert, who missed his second straight practice Thursday with a knee injury. His status will be worth tracking heading into the weekend.
And the Winner is: Philadelphia may end up as the public side, but my analysis still points to the Eagles.
Philly’s defense was heavily impacted from the loss of defensive end Jalen Carter. Fortunately for them, he avoided suspension after spitting on Dak Prescott, which led to his ejection in Week 1. The Eagles run prevention, and defense as a whole, was severely hampered. 
Defensive end Jalen Carter’s Week 1 ejection exposed Philly’s defense, but with no suspension, he’ll be back in the lineup. That’s a huge boost for their run prevention and overall pass rush. On the flip side, Kansas City’s offense &#8211; which already regressed last season &#8211; could be without a fully healthy Xavier Worthy, their top deep threat.
The Eagles bring back essentially the same roster that dominated the Chiefs last year, and with the added benefit of extra rest after playing on Thursday night, Nick Sirianni’s squad should be well-prepared.
I’m expecting Philadelphia to spoil Kansas City once again.
Best Bet: Eagles Moneyline (-116)
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