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Kansas City Chiefs vs Arizona Cardinals Picks

State Farm Stadium

<p>In what could be one of the most exciting games on the Week 1 schedule, Kyler Murray and the Arizona Cardinals will welcome Patrick Mahomes and the Kansas City Chiefs to State Farm Stadium on Sunday afternoon.</p>
<p>Their opener against Arizona is part of an early gauntlet for Kansas City, who will follow their trip to the desert with this stretch: Chargers (home), Colts (away), Bucs (away), Raiders (home), Bills (home), 49ers (away), bye week, Titans (home).</p>
<p>So, a win right out of the gate will be key for KC, especially with many people wondering how well their vaunted offense will fare with Tyreek Hill now with the Miami Dolphins.</p>
<p>But the Cards started fast in each of the past two seasons and will be aiming to do the same this season, though this year&#8211;and perhaps the future of coach Kliff Kingsbury&#8211;will be defined on how they finish.</p>
<h2 id="3mg8p">Kansas City Chiefs vs. Arizona Cardinals Matchup Information and Betting Odds</h2>
<h3 id="uoro">Matchup Information</h3>
<ul>
<li>Matchup: Kansas City Chiefs (0-0) vs. Arizona Cardinals (0-0)</li>
<li>Venue &amp; Location: State Farm Stadium (Glendale, Arizona)</li>
<li>Date: Sunday, September 11, 2022</li>
<li>Game Time: 4:25 p.m. Eastern Time (1:25 p.m. local time)</li>
<li>Chiefs vs. Cardinals TV Info: CBS</li>
</ul>
<h3 id="bj1t6">Chiefs vs. Cardinals Betting Odds</h3>
<p><strong><em>Game odds are via <a href="https://affiliates.bettingnews.com/register/betonline/" target="_blank" rel="noopener noreferrer">BetOnline</a>. Odds from other recommended <a href="/best-online-sportsbooks/" target="_blank" rel="noopener noreferrer">legal sports betting sites</a> may also appear in this article.</em></strong></p>
<h4 id="eb7qo">Spread</h4>
<ul>
<li>Kansas City Chiefs -5.5 (-115)</li>
<li>Arizona Cardinals +5.5 (-105)</li>
</ul>
<h4 id="3j4i7">Over/Under</h4>
<ul>
<li>Over 53.5 (-105)</li>
<li>Under 53.5 (-115)</li>
</ul>
<h4 id="24rkh">Moneyline</h4>
<ul>
<li>Kansas City Chiefs -255</li>
<li>Arizona Cardinals +210</li>
</ul>
<h2 id="fgksu">Kansas City Chiefs vs. Arizona Cardinals Prediction and Best Bets</h2>
<p><strong>Chiefs vs. Cardinals Score Prediction:</strong> Kansas City 38, Arizona 30</p>
<p><strong>Chiefs vs. Cardinals Best Bets:</strong> Kansas City/Arizona over 53.5 (Best Value: -105 at <a href="https://affiliates.bettingnews.com/register/betonline/" target="_blank" rel="noopener noreferrer">BetOnline</a>)</p>
<h2 id="che1m">Other Chiefs vs. Cardinals Content on Betting News</h2>
<ul>
<li><a href="/nfl/matchup/2022-09-11-kansas_city_chiefs-arizona_cardinals-n-1/">Chiefs vs. Cardinals Consensus Picks &amp; Score Projections</a></li>
</ul>
<h2 id="4c3dr">Other NFL Week 1 Content on Betting News</h2>
<ul>
<li><a href="/articles/nfl/nfl-week-1-predictions-odds-spread-over-under-picks/">NFL Week 1 Predictions and Picks</a></li>
<li><a href="/articles/nfl/best-nfl-week-1-player-props-team-prop-bets/">Best NFL Week 1 Player Props &amp; Team Prop Bets</a></li>
<li><a href="/articles/nfl/2022-nfl-rivalry-games-week1/">NFL Rivalry Games to Look Forward to in Week 1</a> (Article &amp; Video)</li>
<li><a href="/articles/nfl/bills-rams-prediction-picks-week-one-september-8-2022/">Bills vs. Rams Prediction &amp; Best Bets</a></li>
<li><a href="/articles/nfl/2022-saints-vs-falcons-week1-predictions-odds-best-bets/">Saints vs. Falcons Prediction &amp; Best Bets</a></li>
<li><a href="/articles/nfl/2022-steelers-vs-bengals-week1-predictions-odds-best-bets/">Steelers vs. Bengals Prediction &amp; Best Bets</a></li>
<li><a href="/articles/nfl/49ers-bears-prediction-picks-week-one-september-11-2022/">49ers vs. Bears Prediction &amp; Best Bets</a></li>
<li><a href="/articles/nfl/2022-browns-vs-panthers-week1-predictions-odds-best-bets/">Browns vs. Panthers Prediction &amp; Best Bets</a></li>
<li><a href="/articles/nfl/2022-patriots-vs-dolphins-week1-predictions-odds-best-bets/">Patriots vs. Dolphins Prediction &amp; Best Bets</a></li>
<li><a href="/articles/nfl/2022-eagles-vs-lions-week1-predictions-odds-best-bets/">Eagles vs. Lions Prediction &amp; Best Bets</a></li>
<li><a href="/articles/nfl/ravens-vs-jets-week-1-betting-joe-flacco-to-start-against-former-team-with-zach-wilson-out/">Ravens vs. Jets Prediction &amp; Best Bets</a></li>
<li><a href="/articles/nfl/2022-colts-vs-texans-week-1-predictions-odds-best-bets/">Colts vs. Texans Prediction &amp; Best Bets</a></li>
<li><a href="/articles/nfl/2022-packers-vs-vikings-week1-predictions-odds-best-bets/">Packers vs. Vikings Prediction &amp; Best Bets</a></li>
<li><a href="/articles/nfl/2022-raiders-vs-chargers-week1-predictions-odds-best-bets/">Raiders vs. Chargers Prediction &amp; Best Bets</a></li>
<li><a href="/articles/nfl/bucs-cowboys-odds-prediction-best-bets-week-1/">Bucs vs. Cowboys Prediction &amp; Best Bets</a></li>
<li><a href="/articles/nfl/broncos-seahawks-odds-prediction-best-bets-week-1/">Broncos vs. Seahawks Prediction &amp; Best Bets</a></li>
</ul>
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Chiefs vs. Cardinals Week 1 Betting: Will Mahomes outlast Murray in desert duel? cover

Chiefs vs. Cardinals Week 1 Betting: Will Mahomes outlast Murray in desert duel?

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