<p>Tampa Bay and Indianapolis will conclude their preseason against each other on Saturday, August 27 at 7:30 p.m. in Indianapolis. Both teams are winless in their first two preseason games, so something has to give.</p>
<p>The biggest issues have been for Tampa Bay and their offensive line. Starters seem to be dropping like flies due to free agency and injuries. Tom Brady is expected to start the game on Saturday, but I don’t see him playing more than the first quarter.</p>
<p>The Colts have the edge in the odds for the preseason finale, and it will be interesting to see which starters actually play for Indianapolis. They are true contenders in the AFC with Matt Ryan at quarterback, so don’t expect to see him much.</p>
<h2 id="2v9it">Tampa Bay Buccaneers vs. Indianapolis Colts Preseason Matchup Information and Betting Odds</h2>
<h3 id="8glop">Matchup Information</h3>
<ul>
<li>Matchup: Tampa Bay Buccaneers (0-2 in preseason) vs. Indianapolis Colts (0-2 in preseason)</li>
<li>Venue &amp; Location: Lucas Oil Stadium (Indianapolis, IN)</li>
<li>Date: Saturday, August 27, 2022</li>
<li>Game Time: 7:30 p.m. Eastern Time</li>
<li>Buccaneers vs. Colts Info: DAZN</li>
</ul>
<h3 id="dpaul">Buccaneers vs. Colts Odds</h3>
<p><strong><em>Game odds are via <a href="https://affiliates.bettingnews.com/register/betonline/">BetOnline</a>. Odds from other <a href="/best-online-sportsbooks/">top online sportsbooks</a> may also be mentioned in this article.</em></strong></p>
<h4 id="dqjot">Spread</h4>
<ul>
<li>Tampa Bay Buccaneers +4 (-110)</li>
<li>Indianapolis Colts -4 (-110)</li>
</ul>
<h4 id="cf78j">Over/Under</h4>
<ul>
<li>Over 41.5 (-115)</li>
<li>Under 41.5 (-105)</li>
</ul>
<h4 id="bk41d">Moneyline</h4>
<ul>
<li>Tampa Bay Buccaneers +170</li>
<li>Indianapolis Colts -200</li>
</ul>
<h2 id="4ia0e">Buccaneers vs. Colts Betting Trends</h2>
<ul>
<li>The Over is 5-1 in the last 6 meetings between these teams</li>
<li>Over is 4-1 in Buccaneers last 5 games on fieldturf</li>
<li>Under is 5-0 in Colts last 5 games overall</li>
<li>Under is 4-1 in Colts last 5 games on fieldturf</li>
</ul>
<h2 id="abvre">Tampa Bay Buccaneers vs. Indianapolis Colts Prediction and Picks</h2>
<p><strong>Buccaneers vs. Colts Prediction:</strong> Colts 24, Buccaneers 17</p>
<p><strong>Buccaneers vs. Colts Picks: </strong>Colts -4 (-110 at <a href="https://sportsbook.fanduel.com/navigation/nfl?tab=preseason-games">BetOnline</a>)</p>
<p>The trends are not conclusive enough for me to bet on the Over/Under in this game. I believe the Under will ultimately hit around 40 or 41 total points, but it is too close to the set range to make a move.</p>
<p>Instead, I would focus your efforts on the spread. Both teams have good value, but I will take the Colts to win by more than 4. Tampa’s offensive line is banged up, and they will need to. play lower level guys to help protect their main guys.</p>
<p>Tom Brady won’t play much in this game. In fact, I wouldn’t be surprised to see him play. one series and then get the heck off the field. The worst thing that could happen to the Bucs is losing Tom Brady in the preseason.</p>
<p>The Colts have the edge, as they will not be going up against the best first-team passing offense in the NFL. Indianapolis can focus on what they need to do on offense without getting into a hole on the scoreboard.</p>
<h2 id="39af9">Other NFL Preseason Stories on Betting News</h2>
<ul>
<li><a href="/articles/nfl/nfl-preseason-week-3-predictions-betting-odds-picks/">NFL Preseason Week 3 Predictions, Odds, Picks for All 16 Games</a></li>
<li><a href="/articles/nfl/most-overrated-teams-in-the-nfl-in-2022/">Most Overrated Teams in the NFL in 2022</a></li>
<li><a href="/articles/nfl/most-underrated-teams-in-the-nfl-in-2022/">Most Underrated Teams in the NFL in 2022</a></li>
<li><a href="/articles/nfl/rams-bengals-preseason-prediction-odds-best-bet/">Rams vs. Bengals Preseason Betting: Back Rams, Under in Super Bowl LVI Rematch</a></li>
</ul>
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