Bills vs Lions Prediction & Picks: Will Detroit upset the odds for a fourth straight win?

Written by: Eddie Griffin
Last Update: Tue Nov 22, 2022, 3:25 am ET
Read Time: 4 minutes

nfl
FINAL
Buffalo Bills Odds
Spread
Total
Moneyline
-9
-110
54.5
-105o
-425
Detroit Lions Odds
Spread
Total
Moneyline
+10.5
-118
54.5
-105u
+360
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