Dimers

Dratings

DunkelIndex

OddsShark

SportGrid

Sports Betting Dime

Moneyline

Total

Point Spread

Away/Home

Wins

Ov / Un

49ers

Bears

Away/Home Defense

Away/Home Offense

Defense

Offense

San Francisco 49ers vs Chicago Bears Picks

Soldier Field

<p>It may not move the needle as much as the other matchups involving NFC West teams, but one of the more intriguing games on the NFL Week 1 schedule sees the San Francisco 49ers visit the Chicago Bears. </p>
<p>In the 2021 NFL Draft, five quarterbacks were selected in the first 15 picks. The 49ers selected Trey Lance third, while the Bears grabbed Justin Fields eight picks later. </p>
<p>Lance mostly spent his rookie year as Jimmy Garoppolo’s backup, while Fields started ten games before having his season ended early by an ankle injury and COVID.</p>
<p>Lance is now the guy in San Francisco, taking the reins for a team expected to make a serious run at a Super Bowl title after falling just short of a trip to the title game last season. </p>
<p>Fields and the Bears don’t have such lofty expectations, but he is expected to make major strides this season under new coach Matt Eberflus after being stifled by former coach Matt Nagy in his rookie campaign.</p>
<h2 id="774au">San Francisco 49ers vs. Chicago Bears Matchup Information and Betting Odds</h2>
<h3 id="cbpv8">Matchup Information</h3>
<ul>
<li>Matchup: San Francisco 49ers (0-0) vs. Chicago Bears (0-0)</li>
<li>Venue &amp; Location: Soldier Field (Chicago, Illinois)</li>
<li>Date: Sunday, September 11, 2022</li>
<li>Game Time: 1:00 p.m. Eastern Time (12:00 p.m. local time)</li>
<li>49ers vs. Bears TV Info: FOX</li>
</ul>
<h3 id="emq4e">49ers vs. Bears Odds</h3>
<p><strong><em>Game odds are via <a href="https://affiliates.bettingnews.com/register/betonline/" target="_blank" rel="noopener noreferrer">BetOnline</a>. Odds from other <a href="/best-online-sportsbooks/" target="_blank" rel="noopener noreferrer">online sports betting sites</a> that we have reviewed may also appear in this article.</em></strong></p>
<h4 id="7qaec">Spread</h4>
<ul>
<li>San Francisco 49ers -6.5 (-120)</li>
<li>Chicago Bears +6.5 (-102)</li>
</ul>
<h4 id="4a8p0">Over/Under</h4>
<ul>
<li>Over 40.5 (-110)</li>
<li>Under 40.5 (-110)</li>
</ul>
<h4 id="bh4o0">Moneyline</h4>
<ul>
<li>San Francisco 49ers -330</li>
<li>Chicago Bears +265</li>
</ul>
<h2 id="1nhdu">San Francisco 49ers vs. Chicago Bears Prediction and Best Bets</h2>
<p><strong>49ers vs. Bears Prediction:</strong> San Francisco 27, Chicago 23</p>
<p><strong>49ers vs. Bears Best Bets:</strong> San Francisco/Chicago over 40 (Best Value: -112 at <a href="https://affiliates.bettingnews.com/register/betus/" target="_blank" rel="noopener noreferrer">BetUS</a>)</p>
<p>While the two talented young quarterbacks may garner a lot of the spotlight in this matchup, defense will be a key part of what both of these franchises do or don’t do this season.</p>
<p>Last season, the 49ers ranked third in total yards allowed per game and tied for ninth in points allowed per game. The Bears ranked 22nd in scoring defense, but they were sixth in yards allowed per game.</p>
<p>All that said, with two mobile quarterbacks and rushing attacks that will be expected to produce, the defenses shouldn’t completely dominate proceedings at Soldier Field on Sunday.</p>
<p>Fields had one of the most impressive performances of his rookie year against the 49ers in a 33-22 loss in Week 8, completing 19 of 27 passes for 175 yards and a touchdown (with one interception) and rushing for 103 yards and a touchdown on ten attempts.</p>
<p>Those kinds of performances could have happened more had Nagy been less conservative with such a dynamic talent, and we should see the benefits of Fields’ offseason work and the coaching change in the opener.</p>
<p>But will it be enough to help the Bears upset the odds and take down one of the favorites for the NFC title? It won’t be, but it won’t be for a lack of trying. </p>
<p>I don’t love the Bears enough to back them to win or even cover, but I feel more certain that they will do their part to help the over hit in this one.</p>
<h2 id="ecm4o">Other 49ers vs. Bears Content on Betting News</h2>
<ul>
<li><a href="/nfl/matchup/2022-09-11-san_francisco_49ers-chicago_bears-n-1/">49ers vs. Bears Consensus Picks &amp; Score Projections</a></li>
</ul>
<h2 id="fsd25">Other NFL Week 1 Content on Betting News</h2>
<ul>
<li><a href="/articles/nfl/nfl-week-1-predictions-odds-spread-over-under-picks/">NFL Week 1 Predictions and Picks</a></li>
<li><a href="/articles/nfl/best-nfl-week-1-player-props-team-prop-bets/">NFL Week 1 Player Props &amp; Team Prop Bets</a></li>
<li><a href="/articles/nfl/bills-rams-prediction-picks-week-one-september-8-2022/">Bills vs. Rams Prediction &amp; Best Bets</a></li>
<li><a href="/articles/nfl/2022-steelers-vs-bengals-week1-predictions-odds-best-bets/">Steelers vs. Bengals Prediction &amp; Best Bets</a></li>
<li><a href="/articles/nfl/2022-browns-vs-panthers-week1-predictions-odds-best-bets/">Browns vs. Panthers Prediction &amp; Best Bets</a></li>
<li><a href="/articles/nfl/2022-patriots-vs-dolphins-week1-predictions-odds-best-bets/">Patriots vs. Dolphins Prediction &amp; Best Bets</a></li>
<li><a href="/articles/nfl/2022-packers-vs-vikings-week1-predictions-odds-best-bets/">Packers vs. Vikings Prediction &amp; Best Bets</a></li>
<li><a href="/articles/nfl/2022-raiders-vs-chargers-week1-predictions-odds-best-bets/">Raiders vs. Chargers Prediction &amp; Best Bets</a></li>
<li><a href="/articles/nfl/bucs-cowboys-odds-prediction-best-bets-week-1/">Bucs vs. Cowboys Prediction &amp; Best Bets</a></li>
<li><a href="/articles/nfl/broncos-seahawks-odds-prediction-best-bets-week-1/">Broncos vs. Seahawks Prediction &amp; Best Bets</a></li>
</ul>
<p><script>if(window.strchfSettings === undefined) window.strchfSettings = {};window.strchfSettings.stats = {url: "https://betting-news.storychief.io/en/49ers-bears-prediction-picks-week-one-september-11-2022?id=739439075&type=2",title: "49ers vs. Bears Week 1 Betting: Will the Trey Lance era start with a Windy City win?",id: "4af471aa-0a59-40f0-a023-eeb51e59464b"};(function(d, s, id) {var js, sjs = d.getElementsByTagName(s)[0];if (d.getElementById(id)) {window.strchf.update(); return;}js = d.createElement(s); js.id = id;js.src = "https://d37oebn0w9ir6a.cloudfront.net/scripts/v0/strchf.js";js.async = true;sjs.parentNode.insertBefore(js, sjs);}(document, 'script', 'storychief-jssdk'))</script></p>

Seahawks vs. 49ers Week 2 Betting: Don’t Expect Much Offense at Levi’s Stadium cover

49ers vs. Bears Week 1 Betting: Will the Trey Lance era start with a Windy City win?

Commanders vs. Giants | NFL Week 15 Breakdown & Best Bets: Battle in the East

Packers vs. Broncos | NFL Week 15 Breakdown & Best Bets: Rocky Mountain Cheese House

Take a deeper dive into this NFL Week 15 matchup with our expert Philadelphia Eagles vs Las Vegas Raiders preview and prop bet.

Philadelphia Eagles vs Las Vegas Raiders Preview & Prop Bet (12/14)

Get ready for one of the coldest games of the season, with our Chicago Bears vs Cleveland Browns preview, predictions and props.

Chicago Bears vs Cleveland Browns Preview, Predictions & Props (12/14)

Lions vs. Rams | NFL Week 15 Breakdown & Best Bets: Goff Goes to Hollywood