CBS Sports

Dratings

DunkelIndex

GameSim

OddsShark

Sports Betting Dime

Moneyline

Total

Point Spread

Away/Home

Wins

Ov / Un

Orioles

Robinson Chirinos

Anthony Bemboom

Adley Rutschman

Jorge Mateo

Ryan Mountcastle

Tyler Nevin

Rougned Odor

Ramón Urías

Kelvin Gutierrez

Kevin Smith

Terrin Vavra

Rylan Bannon

Chris Owings

Richie Martin

Jonathan Araúz

Gunnar Henderson

Jesús Aguilar

Yusniel Diaz

Trey Mancini

Jahmai Jones

Anthony Santander

Ryan McKenna

DJ Stewart

Austin Hays

Cedric Mullins

Kyle Stowers

Brett Phillips

Dean Kremer

Keegan Akin

Zac Lowther

Tyler Wells

Mike Baumann

Alexander Wells

Kyle Bradish

Joey Krehbiel

Tanner Scott

Isaac Mattson

Cionel Pérez

Cole Sulser

Bruce Zimmermann

Logan Gillaspie

Paul Fry

Felix Bautista

Dillon Tate

Bryan Baker

John Means

Jorge López

DL Hall

Jordan Lyles

Spenser Watkins

Travis Lakins Sr.

Marcos Diplán

Chris Ellis

Logan Allen

Denyi Reyes

Nick Vespi

Beau Sulser

Cody Sedlock

Austin Voth

Rico Garcia

Kirk McCarty

Louis Head

Yennier Cano

Jake Reed

Yankees

Ben Rortvedt

Kyle Higashioka

Jose Trevino

Rob Brantly

Giancarlo Stanton

DJ LeMahieu

Oswald Peraza

Anthony Rizzo

Oswaldo Cabrera

Isiah Kiner-Falefa

Josh Donaldson

Gleyber Torres

Luke Voit

Marwin Gonzalez

Matt Carpenter

Ronald Guzmán

Aaron Judge

Aaron Hicks

Miguel Andujar

Estevan Florial

Tim Locastro

Joey Gallo

Everson Pereira

Andrew Benintendi

Harrison Bader

Lucas Luetge

Nestor Cortes

Luis Severino

Michael King

Albert Abreu

Domingo Germán

Wandy Peralta

Joely Rodríguez

Clarke Schmidt

Jonathan Loáisiga

Jameson Taillon

Stephen Ridings

Chad Green

Luis Medina

Clay Holmes

Deivi García

Luis Gil

Ron Marinaccio

Gerrit Cole

JP Sears

Yoendrys Gómez

Jordan Montgomery

Aroldis Chapman

Yoan Aybar

Miguel Castro

David McKay

Manny Bañuelos

Keninson Diaz

Ryan Weber

Shane Greene

Carlos Espinal

Lou Trivino

Scott Effross

Frankie Montas

Luke Bard

Greg Weissert

Anthony Banda

Zack Britton

Jacob Barnes

Chi Chi González

Away/Home Defense

Away/Home Offense

Defense

Offense

Baltimore Orioles vs New York Yankees Picks

Yankee Stadium

<p>After losing two of three at home against the Chicago White Sox, the New York Yankees were staring at a second straight series loss last night against the visiting Baltimore Orioles.</p>
<p>But the Bronx Bombers rallied twice, first after trailing 5-3 in the seventh and then after falling behind 6-5 in the 11th inning, walking it off on Jose Trevino’s RBI single in the bottom of that frame. </p>
<p>Tonight, the two longtime AL East rivals meet in the rubber match at Yankee Stadium, with the Orioles seeking to take a series from the Yankees for the second time this season.</p>
<h2 id="e2u12">Baltimore Orioles vs. New York Yankees Betting Odds and Matchup Information</h2>
<h3 id="bims3">Matchup Information</h3>
<ul>
<li>Matchup: Baltimore Orioles (18-26, 6-15 road, 5th in the AL East) vs. New York Yankees (30-13, 16-7 home, 1st in the AL East)</li>
<li>Venue &amp; Location: Yankee Stadium (The Bronx, New York)</li>
<li>Date: Wednesday, May 25, 2022</li>
<li>Time: 7:05 p.m. Eastern Time</li>
<li>How to Watch Today’s Orioles vs. Yankees Game: MLB Network</li>
</ul>
<h3 id="vsmk">Orioles vs. Yankees Pitching Matchup</h3>
<ul>
<li>Baltimore Orioles: Tyler Wells (2022: 8 starts, 1-3, 4.41 ERA)</li>
<li>New York Yankees: JP Sears (2022: 2 appearances, 1-0, 0.00 ERA)</li>
</ul>
<h3 id="5a4tg">Orioles vs. Yankees Odds</h3>
<p><strong><em>Odds are via <a href="https://affiliates.bettingnews.com/register/betonline/">BetOnline</a>. Odds from our other top reviewed and recommended <a href="/best-online-sportsbooks/">sportsbooks</a> may also be included in this article.</em></strong></p>
<h4 id="9qgkh">Moneyline</h4>
<ul>
<li>Baltimore Orioles +140</li>
<li>New York Yankees -166</li>
</ul>
<h4 id="25nq">Over/Under</h4>
<ul>
<li>OVER 7.5 (-104)</li>
<li>UNDER 7.5 (-118)</li>
</ul>
<h4 id="el1ad">Run Line</h4>
<ul>
<li>Baltimore Orioles +1.5 (-164)</li>
<li>New York Yankees -1.5 (+136)</li>
</ul>
<h2 id="3b8tv">Will the Third Time be the Charm for Wells Against Yankees?</h2>
<p>After pitching in 44 games in relief last season as a rookie, Tyler Wells has made the move to Baltimore’s starting rotation this season.</p>
<p>His numbers don’t jump off of the page, but he has had a number of solid outings among his first eight starts, two of which have come against the Yankees.</p>
<h3 id="4a0hm">2022 Starts for Tyler Wells vs. the Yankees</h3>
<ul>
<li>April 16 vs. Yankees: 4 IP, 0 R, 3 H, 2 BB, 3 K</li>
<li>April at Yankees: 5 IP, 3 H, 2 R, 0 BB, 4 K</li>
</ul>
<p>He received a no-decision in both starts, both of which were 5-2 wins for the Yankees. His numbers on the road are a bit rough, as he is 0-3 with a 7.62 ERA in four road starts, but he has already shown that he can hold his own against the Yankees at Yankee Stadium.</p>
<p>The Orioles are only 6-15 as a road underdog this season and have lost eight of 12 head-to-head meetings with the Yankees thus far in 2022. But they did take two of three from the Yankees in Baltimore last month and their last three losses to the Bronx Bombers have each been by one run.</p>
<p>The Orioles have had a four-run inning in each of the first two games of this series, and they will be aiming to do similar damage against Sears, who is making his first MLB start this evening.</p>
<p>Sears has spent most of his time this season in Triple-A, where he was 1-0 with an 0.83 ERA in six appearances (four starts), allowed only three runs (two earned), 11 hits, and two walks in 21.2 innings, while racking up 30 strikeouts. </p>
<p>But he made two early-season relief appearances for the big league club, including one against the Orioles in the April 16 game that Wells started at Oriole Park. In that appearance, he allowed two hits and a walk in one inning but emerged unscathed.</p>
<h2 id="bamrl">Orioles vs. Yankees Prediction and Best Bets</h2>
<p><strong>Orioles vs. Yankees Prediction:</strong> Orioles to win</p>
<p><strong>Orioles vs. Yankees Best Bets:</strong> Over 7.5 (-104 at BetOnline)</p>
<p>Wells has pitched well against the Yankees this season, and I like him to finally get a reward for those efforts tonight. The Orioles actually rank third in MLB in bullpen ERA (3.11), with only the Astros (2.61) and Tigers (2.98) coming in ahead of them. </p>
<p>So, if Wells can have another strong effort tonight, the pen may be in line for some redemption after a poor night last night. </p>
<p>That said, I do expect runs on the board in the series finale. There have been eight or more runs in seven of the last nine meetings between these two teams, including four of five matchups at Yankee Stadium. </p>
<p>With that in mind, this total is fairly low, especially with a guy making his first MLB start on the mound tonight.</p>
<p><script>if(window.strchfSettings === undefined) window.strchfSettings = {};window.strchfSettings.stats = {url: "https://betting-news.storychief.io/en/orioles-vs-yankees-prediction-best-bets-may-25-2022?id=789740051&type=2",title: "Orioles vs. Yankees (May 25): Will the Bronx Bombers avoid back-to-back series losses?",id: "4af471aa-0a59-40f0-a023-eeb51e59464b"};(function(d, s, id) {var js, sjs = d.getElementsByTagName(s)[0];if (d.getElementById(id)) {window.strchf.update(); return;}js = d.createElement(s); js.id = id;js.src = "https://d37oebn0w9ir6a.cloudfront.net/scripts/v0/strchf.js";js.async = true;sjs.parentNode.insertBefore(js, sjs);}(document, 'script', 'storychief-jssdk'))</script></p>

Tyler Wells pitching against the Yankees tonight

Orioles vs. Yankees (May 25): Will the Bronx Bombers avoid back-to-back series losses?

Orioles vs. Yankees (May 25): Will the Bronx Bombers avoid back-to-back series losses?

Eddie Griffin

More MLB News

2026 World Series Odds & More: The Pete Alonso Effect | December 11, 2025

MLB Signs Streaming Deals with Netflix, ESPN & NBCUniversal

2026 World Series: Too Early Odds | November 2, 2025

Dodgers vs. Blue Jays: Game 7 Player Props | November 1, 2025

Blue Jays vs. Dodgers: Game 7 Odds & Props | November 1, 2025