CBS Sports

Dimers

Dratings

DunkelIndex

FiveThirtyEight

GameSim

OddsShark

Pickwatch

SportGrid

Sports Betting Dime

Wunderdog

pickwise

Moneyline

Total

Point Spread

Away/Home

Wins

Ov / Un

Orioles

Robinson Chirinos

Anthony Bemboom

Adley Rutschman

Jorge Mateo

Ryan Mountcastle

Tyler Nevin

Rougned Odor

Ramón Urías

Kelvin Gutierrez

Kevin Smith

Terrin Vavra

Rylan Bannon

Chris Owings

Richie Martin

Jonathan Araúz

Gunnar Henderson

Jesús Aguilar

Yusniel Diaz

Trey Mancini

Jahmai Jones

Anthony Santander

Ryan McKenna

DJ Stewart

Austin Hays

Cedric Mullins

Kyle Stowers

Brett Phillips

Dean Kremer

Keegan Akin

Zac Lowther

Tyler Wells

Mike Baumann

Alexander Wells

Kyle Bradish

Joey Krehbiel

Tanner Scott

Isaac Mattson

Cionel Pérez

Cole Sulser

Bruce Zimmermann

Logan Gillaspie

Paul Fry

Felix Bautista

Dillon Tate

Bryan Baker

John Means

Jorge López

DL Hall

Jordan Lyles

Spenser Watkins

Travis Lakins Sr.

Marcos Diplán

Chris Ellis

Logan Allen

Denyi Reyes

Nick Vespi

Beau Sulser

Cody Sedlock

Austin Voth

Rico Garcia

Kirk McCarty

Louis Head

Yennier Cano

Jake Reed

Red Sox

Connor Wong

Ronaldo Hernández

Kevin Plawecki

Christian Vázquez

Reese McGuire

Rafael Devers

Hudson Potts

Enrique Hernández

Bobby Dalbec

Jeter Downs

Christian Arroyo

Xander Bogaerts

Trevor Story

Travis Shaw

Yolmer Sánchez

Eric Hosmer

Triston Casas

Yu Chang

Alex Verdugo

J.D. Martinez

Jarren Duran

Jackie Bradley Jr.

Jeisson Rosario

Rob Refsnyder

Jaylin Davis

Franchy Cordero

Tommy Pham

Abraham Almonte

Jake Diekman

Bryan Mata

Darwinzon Hernandez

Chris Sale

Brayan Bello

Josh Taylor

Garrett Whitlock

Josh Winckowski

Connor Seabold

Kutter Crawford

Nick Pivetta

Jay Groome

Rich Hill

Matt Strahm

Phillips Valdez

Ryan Brasier

Austin Davis

Michael Wacha

Eduard Bazardo

Hirokazu Sawamura

Nathan Eovaldi

Matt Barnes

Tanner Houck

Ryan Fernandez

Dan Altavilla

Tyler Danish

Hansel Robles

John Schreiber

James Norwood

Silvino Bracho

Michael Feliz

Kaleb Ort

Jeurys Familia

Zack Kelly

Frank German

Franklin German

Away/Home Defense

Away/Home Offense

Defense

Offense

Baltimore Orioles vs Boston Red Sox Picks

Fenway Park

<p>After a win at Fenway Park on Monday, the Baltimore Orioles had every chance to make a serious run at snatching a playoff berth away from the Seattle Mariners. </p>
<p>The Boston Red Sox had other ideas, however, and have delivered a potentially mortal blow to Baltimore’s postseason hopes with back-to-back wins on Tuesday and Wednesday. </p>
<p>With the Seattle Mariners defeating the Texas Rangers last night, the Orioles are now 4.5 games back of the final American League wild-card spot with just seven games remaining for them.</p>
<p>A win for the Red Sox in this afternoon’s finale wouldn’t mathematically eliminate the O’s, but it would leave them needing a near-miracle to make some magic happen.</p>
<h2 id="9bidd">Baltimore Orioles vs. Boston Red Sox Matchup Information and Betting Odds</h2>
<h3 id="65vg2">Matchup Information</h3>
<ul>
<li>Matchup: Baltimore Orioles (80-75, 36-41 away, 4th in the AL East) vs. Boston Red Sox (74-81, 39-38 home, 5th in the AL East)</li>
<li>Venue &amp; Location: Fenway Park (Boston, Massachusetts)</li>
<li>Date: Thursday, September 29, 2022</li>
<li>Game Time: 1:35 p.m. Eastern Time</li>
</ul>
<h3 id="28f4t">Orioles vs. Red Sox Pitching Matchup</h3>
<ul>
<li>Baltimore: RHP Mike Baumann (2022: 11 appearances &#8211; two starts, 1-3, 4.32 ERA)</li>
<li>Boston: RHP Nathan Eovaldi (2022: 18 starts, 5-3, 4.15 ERA)</li>
</ul>
<h3 id="amp7d">Orioles vs. Red Sox Odds</h3>
<p><strong><em>Game odds are via <a href="https://affiliates.bettingnews.com/register/betonline/" target="_blank" rel="noopener noreferrer">BetOnline</a>. Odds from our other recommended <a href="/best-online-sportsbooks/" target="_blank" rel="noopener noreferrer">legal sports betting sites</a> may also appear in this article.</em></strong></p>
<h4 id="95q33">Moneyline</h4>
<ul>
<li>Baltimore Orioles +136</li>
<li>Boston Red Sox -162</li>
</ul>
<h4 id="emjto">Over/Under</h4>
<ul>
<li>Over 9 (-114)</li>
<li>Under 9 (-106)</li>
</ul>
<h4 id="33t7q">Run Line</h4>
<ul>
<li>Baltimore Orioles +1.5 (-146)</li>
<li>Boston Red Sox -1.5 (+122)</li>
</ul>
<h2 id="3o8ob">Baltimore Orioles vs. Boston Red Sox Prediction and Betting Picks</h2>
<p><strong>Orioles vs. Red Sox Prediction:</strong> Red Sox to win</p>
<p><strong>Orioles vs. Red Sox Pick:</strong> Red Sox -1.5 (Best Value: +133 at <a href="https://affiliates.bettingnews.com/register/betus/" target="_blank" rel="noopener noreferrer">BetUS</a>)</p>
<p>After finishing fourth behind Robbie Ray, Gerrit Cole, and Lance Lynn in AL Cy Young voting last season, Eovaldi was considered a potential Cy Young contender before this season started.</p>
<p>But he has been limited to 18 starts due to two extended IL spells, first in June and July due to back issues and then in August and this month due to shoulder/neck issues. </p>
<p>And when he has pitched, he has put together great numbers on the road (4-0, 2.64 ERA in 10 starts) but struggled for success at Fenway Park (0-3, 6.26 ERA in eight starts).</p>
<p>Eovaldi has made more career starts against Baltimore than any other team. In his 17 starts against the O’s, he is 8-2 with a 3.29 ERA, and he tossed a complete game against them at home on May 28.</p>
<p>I’m always cautious of backing a pitcher who is returning from a stint on the IL, but given Eovaldi’s track record against Baltimore, this is a favorable spot. </p>
<p>This season, 51 of 74 Boston’s 74 wins (almost 69 percent) have come by 2+ runs, including 29 of their 39 home wins (over 74 percent). </p>
<p>With the ML a bit out of the ideal range, the RL has a lot of value with the Red Sox having a decided advantage in the mound matchup.</p>
<h2 id="6bboo">More Orioles vs. Red Sox Content on Betting News</h2>
<ul>
<li><a href="/mlb/matchup/2022-09-29-baltimore_orioles-boston_red_sox-n-1/">Orioles vs. Red Sox Consensus Picks, Score Projections &amp; Betting Stats (9/29)</a></li>
</ul>
<h2 id="654j7">More MLB Content on Betting News</h2>
<ul>
<li><a href="/mlb/odds/">Today’s MLB Odds</a></li>
</ul>
<p><script>if(window.strchfSettings === undefined) window.strchfSettings = {};window.strchfSettings.stats = {url: "https://betting-news.storychief.io/en/orioles-red-sox-prediction-picks-september-29-2022?id=1609985196&type=2",title: "Orioles vs. Red Sox (Sept. 29): Baltimore’s playoff bid on its last legs ahead of Fenway finale",id: "4af471aa-0a59-40f0-a023-eeb51e59464b"};(function(d, s, id) {var js, sjs = d.getElementsByTagName(s)[0];if (d.getElementById(id)) {window.strchf.update(); return;}js = d.createElement(s); js.id = id;js.src = "https://d37oebn0w9ir6a.cloudfront.net/scripts/v0/strchf.js";js.async = true;sjs.parentNode.insertBefore(js, sjs);}(document, 'script', 'storychief-jssdk'))</script></p>

Orioles vs. Red Sox (Sept. 29): Baltimore’s playoff bid on its last legs ahead of Fenway finale cover

Orioles vs. Red Sox (Sept. 29): Baltimore’s playoff bid on its last legs ahead of Fenway finale

Orioles vs. Red Sox (Sept. 29): Baltimore’s playoff bid on its last legs ahead of Fenway finale

Eddie Griffin

More MLB News

2026 MLB Player Props Futures: Regression is Due | January 31, 2026

2026 MLB Player Prop Futures: Early Leans & Odds | January 29, 2026

2026 Home Run Futures: The Italian Nightmare | January 26, 2026

2026 Los Angeles Dodgers: The Monstars Unite | January 19, 2026

2026 New York Mets: Bo Bichette Signing | January 19, 2026