CBS Sports

Dratings

DunkelIndex

OddsShark

Sports Betting Dime

Moneyline

Total

Point Spread

Away/Home

Wins

Ov / Un

Red Sox

Kevin Plawecki

Christian Vázquez

Connor Wong

Rafael Devers

Jonathan Araúz

Enrique Hernández

Bobby Dalbec

Michael Chavis

Christian Arroyo

Xander Bogaerts

Marwin Gonzalez

Travis Shaw

Yairo Muñoz

Jack Lopez

Taylor Motter

Jose Iglesias

Hunter Renfroe

Alex Verdugo

J.D. Martinez

Franchy Cordero

Danny Santana

Jarren Duran

Kyle Schwarber

Eduardo Rodriguez

Austin Brice

Colten Brewer

Adam Ottavino

Darwinzon Hernandez

Josh Taylor

Garrett Whitlock

Nick Pivetta

Phillips Valdez

Ryan Brasier

Matt Andriese

Garrett Richards

Hirokazu Sawamura

Nathan Eovaldi

Matt Barnes

Martín Pérez

Tanner Houck

Eduard Bazardo

Brandon Workman

Brandon Brennan

Ryan Weber

Yacksel Ríos

Hansel Robles

Austin Davis

Chris Sale

Raynel Espinal

Brad Peacock

Stephen Gonsalves

John Schreiber

Kutter Crawford

Michael Feliz

Kaleb Ort

Connor Seabold

Orioles

Pedro Severino

Chance Sisco

Austin Wynns

Nick Ciuffo

Chris Davis

Maikel Franco

Yolmer Sánchez

Rio Ruiz

Ryan Mountcastle

Pat Valaika

Richie Martin

Ramón Urías

Freddy Galvis

Tyler Nevin

Domingo Leyba

Kelvin Gutierrez

Jorge Mateo

Trey Mancini

Jahmai Jones

Anthony Santander

DJ Stewart

Austin Hays

Cedric Mullins

Ryan McKenna

Stevie Wilkerson

Dean Kremer

Travis Lakins Sr.

Keegan Akin

Shawn Armstrong

Mac Sceroler

Tyler Wells

Cesar Valdez

Tanner Scott

Cole Sulser

Bruce Zimmermann

Paul Fry

Dillon Tate

John Means

Jorge López

Matt Harvey

Adam Plutko

Wade LeBlanc

Zac Lowther

Jay Flaa

Isaac Mattson

Brandon Waddell

Hunter Harvey

Thomas Eshelman

Mickey Jannis

Alexander Wells

Konner Wade

Spenser Watkins

Shaun Anderson

Conner Greene

Marcos Diplán

Dusten Knight

Fernando Abad

Chris Ellis

Zack Burdi

Mike Baumann

Manny Barreda

Eric Hanhold

Brooks Kriske

Joey Krehbiel

Away/Home Defense

Away/Home Offense

Defense

Offense

Boston Red Sox vs Baltimore Orioles Picks

Oriole Park at Camden Yards

<p>The Boston Red Sox have picked a pretty bad time to have a four-game losing streak, haven’t they? With their 4-2 loss last night to the Baltimore Orioles, the Red Sox are now only a half-game ahead of the surging Seattle Mariners for the second AL wild-card berth. Only a few days ago, MLB betting odds heavily favored the Red Sox to land one of the two AL wild cards. Now things are looking rather shaky for Boston.</p>
<p>Last night, the Red Sox were on track to help themselves, as Chris Sale coasted through five scoreless innings. But things unraveled in the sixth, with the Orioles tallying a trio of runs to take the lead. And on a quiet night for Boston’s bats, Baltimore’s lead held up. </p>
<p>With the Mariners charging hard and the Toronto Blue Jays still in the mix despite their own loss last night to the New York Yankees, the Red Sox can ill-afford another loss to the Orioles tonight.</p>
<h2 id="5jerg">Boston Red Sox (88-69) vs Baltimore Orioles (51-106), MASN, 7:05 p.m. ET</h2>
<h3 id="8udem">Probable Pitchers</h3>
<ul>
<li>Boston Red Sox: Nathan Eovaldi (10-9, 3.88 ERA)</li>
<li>Baltimore Orioles: Zac Lowther (1-2, 7.66 ERA)</li>
</ul>
<h3 id="dh7hc">Boston Red Sox vs Baltimore Orioles MLB Betting Odds</h3>
<h4 id="9p0gk">Moneyline</h4>
<ul>
<li>Boston Red Sox -255</li>
<li>Baltimore Orioles +210</li>
</ul>
<h4 id="flgc2">Total</h4>
<ul>
<li>OVER 9.5 (-118)</li>
<li>UNDER 9.5 (-104)</li>
</ul>
<h4 id="vn0s">Run Line</h4>
<ul>
<li>Boston Red Sox -1.5 (-166)</li>
<li>Baltimore Orioles +1.5 (+138)</li>
</ul>
<p><em><strong>Boston Red Sox vs Baltimore Orioles odds are via <a href="/best-online-sportsbooks/betonline/">BetOnline Sportsbook</a> as of Wednesday, September 29, 2021 at 9:40 a.m. ET. Want to see MLB betting odds from several top <a href="/best-online-sportsbooks/">online sportsbooks</a> for each MLB matchup every day? Check out our <a href="/mlb/odds/">MLB odds</a>.</strong></em></p>
<h3 id="3ia2v">Boston Red Sox vs Baltimore Orioles MLB Betting Consensus</h3>
<h4 id="7m33b">Moneyline</h4>
<ul>
<li>80% Boston Red Sox</li>
<li>20% Baltimore Orioles</li>
</ul>
<h4 id="bd5j1">Total (at O/U 9.5)</h4>
<ul>
<li>20% OVER 9.5</li>
<li>80% UNDER 9.5</li>
</ul>
<h4 id="88bj4">Run Line (at -/+1.5)</h4>
<ul>
<li>60% Boston Red Sox -1.5</li>
<li>40% Baltimore Orioles +1.5</li>
</ul>
<p><a href="/mlb/matchup/2021-09-29-boston_red_sox-baltimore_orioles-n-1/">Boston Red Sox vs Baltimore Orioles Matchup: MLB Betting Picks, Odds, Stats and More</a></p>
<h2 id="bolea">Boston Red Sox vs Baltimore Orioles Betting Outlook</h2>
<p>The Red Sox have been one of MLB’s top offensive teams all season long, but they hit a bad patch at the worst possible time. Only the Houston Astros (5.33), Tampa Bay Rays (5.3), and Toronto Blue Jays (5.16) are averaging more runs per game than the Red Sox, and only the Astros (.267) and Blue Jays (.264) have a higher team batting average than the Red Sox (.261). </p>
<p>But over the last four games, the Red Sox have managed only 11 runs. And last night they managed only two runs and three hits as they watched a needed win slip away. After Hunter Renfroe led off the top of the sixth with a homer to put Boston ahead 2-0, Baltimore’s bullpen mowed down the final 12 hitters to help the home team get the win.</p>
<p>A little run support tonight could go a long way for Eovaldi. He has only one win in his last 14 starts, but prior to his most recent start, he had actually pitched fairly well over the last month and a half. He gave up seven runs in only 2.2 innings against the Yankees on Friday, but he had a 2.29 ERA in his previous eight starts. </p>
<p>The tea leaves read favorably for Eovaldi bouncing back from his early exit on Friday. That was the seventh time this season that he has allowed five or more runs. In the previous six instances, he is 2-1 with a 2.74 ERA in the following starts. Four of the six starts were quality starts, and in five of the six starts, he allowed two or fewer runs. The only outlier occurred in his final July start and his first August start, in which he had a rough go of it against the Rays and Blue Jays.</p>
<h3 id="3snbt">Lowther Looks for More After First MLB Win</h3>
<p>The Orioles have won only one series this month, but they did split four games with the Texas Rangers in their last series. In Thursday’s opener, Lowther picked up his first MLB win. And it was well-earned, as he tossed five shutout innings, allowed only three hits and two walks, and struck out a career-high seven in the Orioles’ 3-0 win.</p>
<p>If the Orioles can win tonight or tomorrow night, they will bookend the season series with the Red Sox with series wins. Since opening the season with a sweep at Fenway, Baltimore had only one win in 13 games against Boston before last night’s win. In those 13 games, the Red Sox had averaged 7.9 runs per game, and nine of their 12 wins had come by three or more runs, including four of their five road wins.</p>
<h3 id="5u4qa">MLB Betting Trends to Consider for Boston Red Sox vs Baltimore Orioles</h3>
<ul>
<li>The Orioles are 0-6 in the next game following their last six wins. In those six games, they have given up 42 runs, an average of seven runs per game.</li>
<li>For the season, the Orioles are 19-31 following a win.</li>
<li>The Orioles are already assured of having the league’s worst home record. With two home games left, Baltimore comes in at 26-53 at home. The Arizona Diamondbacks have the second-worst mark at 30-48.</li>
</ul>
<h3 id="d3qa8">Boston Red Sox vs Baltimore Orioles Best Bets</h3>
<h4 id="3t11">Boston Red Sox -2.5</h4>
<p>There isn’t any value in the ML, and there is minimal value in backing Red Sox -1.5. But there is some pretty solid value in the -2.5, even though it’s not at plus odds like alternate run lines of this nature often are. The head-to-head numbers above line up well, and so does the situation. </p>
<h4 id="98h39">Boston Red Sox Team Total OVER 6 Runs</h4>
<p>The Red Sox have done well about not having too many extended stretches in which the bats struggled to push runs across. I like their recent stumble to come to an end tonight against Lowther, who has allowed 10 runs and 12 hits in 5.2 innings (across two starts) against the Red Sox this season.</p>
<p><script>if(window.strchfSettings === undefined) window.strchfSettings = {};window.strchfSettings.stats = {url: "https://betting-news.storychief.io/en/boston-red-sox-baltimore-orioles-mlb-betting-preview-odds-trends-best-bets-september-29-2021?id=2119914359&type=2",title: "Boston Red Sox vs Baltimore Orioles Preview: Will the Red Sox Return to Dominant Ways Against Orioles in Must-Win Matchup?",id: "4af471aa-0a59-40f0-a023-eeb51e59464b"};(function(d, s, id) {var js, sjs = d.getElementsByTagName(s)[0];if (d.getElementById(id)) {window.strchf.update(); return;}js = d.createElement(s); js.id = id;js.src = "https://d37oebn0w9ir6a.cloudfront.net/scripts/v0/strchf.js";js.async = true;sjs.parentNode.insertBefore(js, sjs);}(document, 'script', 'storychief-jssdk'))</script></p>

Boston Red Sox vs Baltimore Orioles Preview: Will the Red Sox Return to Dominant Ways Against Orioles in Must-Win Matchup?

Boston Red Sox vs Baltimore Orioles Preview: Will the Red Sox Return to Dominant Ways Against Orioles in Must-Win Matchup?

Eddie Griffin

More MLB News

2026 World Series Odds & More: The Pete Alonso Effect | December 11, 2025

MLB Signs Streaming Deals with Netflix, ESPN & NBCUniversal

2026 World Series: Too Early Odds | November 2, 2025

Dodgers vs. Blue Jays: Game 7 Player Props | November 1, 2025

Blue Jays vs. Dodgers: Game 7 Odds & Props | November 1, 2025